WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience MBF Bioscience Neurolucida
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (54)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Syroid, D. E.
Right arrow Articles by Kilpatrick, T. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Syroid, D. E.
Right arrow Articles by Kilpatrick, T. J.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 2000, 20(15):5741-5747

Induction of Postnatal Schwann Cell Death by the Low-Affinity Neurotrophin Receptor In Vitro and after Axotomy

Daniel E. Syroid3, Peter J. Maycox4, Merja Soilu-Hänninen1, Steven Petratos1, Tamara Bucci1, Patrick Burrola3, Simon Murray2, Surindar Cheema2, Kuo-Fen Lee3, Greg Lemke3, and Trevor J. Kilpatrick1

1 The Walter and Eliza Hall Institute of Medical Research, Post Office The Royal Melbourne Hospital, Victoria 3050, Australia, 2 Monash University, Clayton, Victoria 3168, Australia, 3 The Salk Institute for Biological Studies, La Jolla, California 92186-5800, and 4 SmithKline Beecham Pharmaceuticals, Harlow, Essex CM19 5AW, United Kingdom

Schwann cells express the low-affinity neurotrophin receptor (p75), but no role for either the neurotrophins or their cognate receptors in Schwann cell development has been established. We have found that Schwann cells isolated from postnatal day 1 (P1) or P2 mice that were p75-deficient exhibited potentiated survival compared to wild-type cells after growth factor and serum withdrawal. There was, however, no disparity in the survival of p75-deficient and wild-type Schwann cells isolated at embryonic day 15, suggesting that the death-inducing effects of p75 are developmentally regulated. A comparable degree of cell death was also observed in the sciatic nerves of both wild-type and p75-deficient mice at P1. However, 24 hr after axotomy, there was a 13-fold increase in the percentage of apoptotic nuclei in the distal nerve stumps of the transected sciatic nerves of neonatal wild-type but not p75-deficient mice. The expression of both the p75 and nerve growth factor (NGF) genes was upregulated after axotomy in neonatal wild-type nerves. Collectively, these results suggest that NGF-mediated activation of p75 is likely to be an important mediator of Schwann cell apoptosis in the context of peripheral nerve injury.

Key words: Schwann cells; cell death; apoptosis; p75; low-affinity neurotrophin receptor; p75 knock-out

Copyright © 2000 Society for Neuroscience  0270-6474/00/20155741-07$05.00/0


This article has been cited by other articles:


Home page
 J. Cell Biol.Home page
B. D. Sachs, G. S. Baillie, J. R. McCall, M. A. Passino, C. Schachtrup, D. A. Wallace, A. J. Dunlop, K. F. MacKenzie, E. Klussmann, M. J. Lynch, et al.
p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway
J. Cell Biol., July 30, 2007; 177(6): 1119 - 1132.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. M. Lino, S. Atanasoski, M. Kvajo, B. Fayard, E. Moreno, H. R. Brenner, U. Suter, and D. Monard
Mice Lacking Protease Nexin-1 Show Delayed Structural and Functional Recovery after Sciatic Nerve Crush
J. Neurosci., April 4, 2007; 27(14): 3677 - 3685.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. M. Campana, X. Li, N. Dragojlovic, J. Janes, A. Gaultier, and S. L. Gonias
The Low-Density Lipoprotein Receptor-Related Protein Is a Pro-Survival Receptor in Schwann Cells: Possible Implications in Peripheral Nerve Injury
J. Neurosci., October 25, 2006; 26(43): 11197 - 11207.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. D'Antonio, A. Droggiti, M. L. Feltri, J. Roes, L. Wrabetz, R. Mirsky, and K. R. Jessen
TGFbeta Type II Receptor Signaling Controls Schwann Cell Death and Proliferation in Developing Nerves.
J. Neurosci., August 15, 2006; 26(33): 8417 - 8427.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Srinivasan, C. H. Roque, B. L. Hempstead, M. R. Al-Ubaidi, and R. S. Roque
Microglia-derived Pronerve Growth Factor Promotes Photoreceptor Cell Death via p75 Neurotrophin Receptor
J. Biol. Chem., October 1, 2004; 279(40): 41839 - 41845.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. L. Bhakar, J. L. Howell, C. E. Paul, A. H. Salehi, E. B. E. Becker, F. Said, A. Bonni, and P. A. Barker
Apoptosis Induced by p75NTR Overexpression Requires Jun Kinase-Dependent Phosphorylation of Bad
J. Neurosci., December 10, 2003; 23(36): 11373 - 11381.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Peterson and E. Bogenmann
Osmotic Swelling Induces p75 Neurotrophin Receptor (p75NTR) Expression via Nitric Oxide
J. Biol. Chem., September 5, 2003; 278(36): 33943 - 33950.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. Palmada, S. Kanwal, N.J. Rutkoski, C. Gustafson-Brown, R.S. Johnson, R. Wisdom, and B.D. Carter
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
J. Cell Biol., August 5, 2002; 158(3): 453 - 461.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. K. Winseck, J. Caldero, D. Ciutat, D. Prevette, S. A. Scott, G. Wang, J. E. Esquerda, and R. W. Oppenheim
In Vivo Analysis of Schwann Cell Programmed Cell Death in the Embryonic Chick: Regulation by Axons and Glial Growth Factor
J. Neurosci., June 1, 2002; 22(11): 4509 - 4521.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
S. Sancho, P. Young, and U. Suter
Regulation of Schwann cell proliferation and apoptosis in PMP22-deficient mice and mouse models of Charcot-Marie-Tooth disease type 1A
Brain, November 1, 2001; 124(11): 2177 - 2187.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Khursigara, J. Bertin, H. Yano, H. Moffett, P. S. DiStefano, and M. V. Chao
A Prosurvival Function for the p75 Receptor Death Domain Mediated via the Caspase Recruitment Domain Receptor-Interacting Protein 2
J. Neurosci., August 15, 2001; 21(16): 5854 - 5863.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. J. Coulson, K. Reid, M. Baca, K. A. Shipham, S. M. Hulett, T. J. Kilpatrick, and P. F. Bartlett
Chopper, a New Death Domain of the p75 Neurotrophin Receptor That Mediates Rapid Neuronal Cell Death
J. Biol. Chem., September 22, 2000; 275(39): 30537 - 30545.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, J. H. Bauer, Y. Li, Z. Shao, F. S. Zetoune, E. Cattaneo, and C. Vincenz
Characterization of a p75NTR Apoptotic Signaling Pathway Using a Novel Cellular Model
J. Biol. Chem., August 31, 2001; 276(36): 33812 - 33820.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
M. L. Feltri, D. G. Porta, S. C. Previtali, A. Nodari, B. Migliavacca, A. Cassetti, A. Littlewood-Evans, L. F. Reichardt, A. Messing, A. Quattrini, et al.
Conditional disruption of {beta}1 integrin in Schwann cells impedes interactions with axons
J. Cell Biol., January 7, 2002; 156(1): 199 - 210.
[Abstract] [Full Text] [PDF]


-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2008 by Society for Neuroscience ONLINE ISSN: 1529-2401
-