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The Journal of Neuroscience, August 1, 2000, 20(15):5764-5774
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Tarik F. Haydar, Feng Wang, Michael L. Schwartz, and Pasko Rakic Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510
Recent studies have implicated the classical neurotransmitters GABA and glutamate in the regulation of neural progenitor proliferation. We now show that GABA and glutamate have opposite effects on the two neural progenitor populations in the ventricular zones (VZs) and subventricular zones (SVZs) of the embryonic cerebrum. Application of either molecule to organotypic slice cultures dramatically increases proliferation in the VZ by shortening the cell cycle, whereas proliferation in the SVZ is decreased. These disparate effects, measured both by bromodeoxyuridine uptake and the expansion of retrovirally labeled progenitor clones, are mimicked by the application of specific GABA and glutamate agonists and are blocked by antagonists. Thus, the relative contributions of the VZ and SVZ to neocortical growth may be regulated by differential responsiveness to GABA and glutamate.
Key words: neurogenesis; neurotransmitter; progenitor; cell cycle; cerebral cortex; corticogenesis
Copyright © 2000 Society for Neuroscience 0270-6474/00/20155764-11$05.00/0
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