QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (35) Citing Articles via Google Scholar Google Scholar Articles by Tomioka, N. Articles by Hirata, T. Search for Related Content PubMed PubMed Citation Articles by Tomioka, N. Articles by Hirata, T.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 2000, 20(15):5802-5812

Neocortical Origin and Tangential Migration of Guidepost Neurons in the Lateral Olfactory Tract

Naomi Tomioka¹, Noriko Osumi², Yasufumi Sato^{1, 3}, Takayoshi Inoue⁴, Shun Nakamura⁴, Hajime Fujisawa^{1, 5}, and Tatsumi Hirata^{3, 5, 6}

¹ Division of Biological Science, Nagoya University Graduate School of Science, Chikusa-ku, Nagoya 464-8602, Japan, ² Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8575, Japan, ³ Division of Brain Function, National Institute of Genetics, Mishima 411-8540, Japan, ⁴ Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, Kodaira 187-8501, Japan, ⁵ Core Research for Evolution Science and Technology, and ⁶ Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation (JST), Kawaguchi 332-0012, Japan

The early-generated neurons designated as lot cells specifically mark the future site of the lateral olfactory tract (LOT) and guide LOT axons. We investigated the mechanism of how lot cells develop and get localized in the LOT position. Lot cells differentiated from neuroepithelial cells in all regions of the neocortex but not from those in the ganglionic eminence in culture. Cell tracing analyses demonstrated that lot cells generated from the neocortex subsequently followed a tangential migration stream ventrally toward the LOT position. Mutant mouse embryos lacking the function of transcription factor Gli3 showed disturbances of the migration stream and translocation of lot cells in the dorsal telencephalon. These results reveal a new type of neuronal migration in the telencephalon and introduce an unexpected dramatic feature of the earliest regionalization of the telencephalon.

Key words: migration; neurogenesis; guidepost; lot cell; Gli3; Xt

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/20155802-11$05.00/0

This article has been cited by other articles:

				M.-A. Renault, J. Roncalli, J. Tongers, S. Misener, T. Thorne, K. Jujo, A. Ito, T. Clarke, C. Fung, M. Millay, et al. The Hedgehog Transcription Factor Gli3 Modulates Angiogenesis Circ. Res., October 9, 2009; 105(8): 818 - 826. [Abstract] [Full Text] [PDF]

				F. Garcia-Moreno, L. Lopez-Mascaraque, and J. A. de Carlos Early Telencephalic Migration Topographically Converging in the Olfactory Cortex Cereb Cortex, June 1, 2008; 18(6): 1239 - 1252. [Abstract] [Full Text] [PDF]

				K. Ito, T. Kawasaki, S. Takashima, I. Matsuda, A. Aiba, and T. Hirata Semaphorin 3F Confines Ventral Tangential Migration of Lateral Olfactory Tract Neurons onto the Telencephalon Surface J. Neurosci., April 23, 2008; 28(17): 4414 - 4422. [Abstract] [Full Text] [PDF]

				X. Huang, Y. Litingtung, and C. Chiang Ectopic sonic hedgehog signaling impairs telencephalic dorsal midline development: implication for human holoprosencephaly Hum. Mol. Genet., June 15, 2007; 16(12): 1454 - 1468. [Abstract] [Full Text] [PDF]

				C. Fouquet, T. Di Meglio, L. Ma, T. Kawasaki, H. Long, T. Hirata, M. Tessier-Lavigne, A. Chedotal, and K. T. Nguyen-Ba-Charvet Robo1 and Robo2 Control the Development of the Lateral Olfactory Tract J. Neurosci., March 14, 2007; 27(11): 3037 - 3045. [Abstract] [Full Text] [PDF]

				B. Saha, P. Hari, D. Huilgol, and S. Tole Dual Role for LIM-Homeodomain Gene Lhx2 in the Formation of the Lateral Olfactory Tract J. Neurosci., February 28, 2007; 27(9): 2290 - 2297. [Abstract] [Full Text] [PDF]

				R. S. E. Carney, T. B. Alfonso, D. Cohen, H. Dai, S. Nery, B. Stoica, J. Slotkin, B. S. Bregman, G. Fishell, and J. G. Corbin Cell Migration along the Lateral Cortical Stream to the Developing Basal Telencephalic Limbic System. J. Neurosci., November 8, 2006; 26(45): 11562 - 11574. [Abstract] [Full Text] [PDF]

				T. Nomura, J. Holmberg, J. Frisen, and N. Osumi Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5 Development, April 1, 2006; 133(7): 1335 - 1345. [Abstract] [Full Text] [PDF]

				T. Kawasaki, K. Ito, and T. Hirata Netrin 1 regulates ventral tangential migration of guidepost neurons in the lateral olfactory tract Development, March 1, 2006; 133(5): 845 - 853. [Abstract] [Full Text] [PDF]

				J. A. Gorski, T. Talley, M. Qiu, L. Puelles, J. L. R. Rubenstein, and K. R. Jones Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage J. Neurosci., August 1, 2002; 22(15): 6309 - 6314. [Abstract] [Full Text] [PDF]

				K. T. Nguyen-Ba-Charvet, A. S. Plump, M. Tessier-Lavigne, and A. Chedotal Slit1 and Slit2 Proteins Control the Development of the Lateral Olfactory Tract J. Neurosci., July 1, 2002; 22(13): 5473 - 5480. [Abstract] [Full Text] [PDF]

				D. Caric, H. Raphael, J. Viti, A. Feathers, D. Wancio, and L. Lillien EGFRs mediate chemotactic migration in the developing telencephalon Development, November 1, 2001; 128(21): 4203 - 4216. [Abstract] [Full Text] [PDF]

				T. Hamasaki, S. Goto, S. Nishikawa, and Y. Ushio Early-generated Preplate Neurons in the Developing Telencephalon: Inward Migration into the Developing Striatum Cereb Cortex, May 1, 2001; 11(5): 474 - 484. [Abstract] [Full Text] [PDF]

				T. Hirata, H. Fujisawa, J. Y. Wu, and Y. Rao Short-Range Guidance of Olfactory Bulb Axons Is Independent of Repulsive Factor Slit J. Neurosci., April 1, 2001; 21(7): 2373 - 2379. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help