WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sybirska, E.
Right arrow Articles by Goldman-Rakic, P. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sybirska, E.
Right arrow Articles by Goldman-Rakic, P. S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 2000, 20(15):5827-5834

Prominence of Direct Entorhinal-CA1 Pathway Activation in Sensorimotor and Cognitive Tasks Revealed by 2-DG Functional Mapping in Nonhuman Primate

Elzbieta Sybirska, Lila Davachi, and Patricia S. Goldman-Rakic

Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510

The trisynaptic pathway from entorhinal cortex to the hippocampus has long been regarded as the major route of information transfer underlying memory consolidation. Most physiological studies of this pathway involve recording from hippocampal slices. We have used both single- and double-label 2-deoxyglucose autoradiographic methods to image the pattern of activation in the hippocampal formation of 14 rhesus monkeys performing cognitive tasks, varying in content (spatial or nonspatial), process (working memory or associative memory), and mode of response (oculomotor or manual). These studies revealed a highly differentiated pattern of metabolic activation throughout the rostrocaudal extent of the hippocampal formation that was common to all behavioral conditions examined. This pattern consisted of intense activation of the stratum lacunosum-moleculare of CA1 and the subiculum, contrasting with barely detectable activity in CA3 and modest activation in the dentate gyrus, which did not include its molecular layer. These findings indicate a remarkable invariance in hippocampal activation under conditions of varied content, varied process, and varied mode of response and an heretofore-unappreciated preferential engagement of the direct rather than the trisynaptic pathway during performance of a wide range of behavioral tasks.

Key words: hippocampus; trisynaptic pathway; CA3; dentate gyrus; oculomotor delayed-response task; delayed match-to-sample task; rhesus monkey

Copyright © 2000 Society for Neuroscience  0270-6474/00/20155827-08$05.00/0


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
J. A. Rosenkranz and D. Johnston
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.
J. Neurosci., March 22, 2006; 26(12): 3229 - 3244.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. W. Ang, G. C. Carlson, and D. A. Coulter
Hippocampal CA1 Circuitry Dynamically Gates Direct Cortical Inputs Preferentially at Theta Frequencies
J. Neurosci., October 19, 2005; 25(42): 9567 - 9580.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. A. Otmakhova, J. Lewey, B. Asrican, and J. E. Lisman
Inhibition of Perforant Path Input to the CA1 Region by Serotonin and Noradrenaline
J Neurophysiol, August 1, 2005; 94(2): 1413 - 1422.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. J. Price, B. Cauli, E. R. Kovacs, A. Kulik, B. Lambolez, R. Shigemoto, and M. Capogna
Neurogliaform Neurons Form a Novel Inhibitory Network in the Hippocampal CA1 Area
J. Neurosci., July 20, 2005; 25(29): 6775 - 6786.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. Inoue, A. Mikami, I. Ando, and H. Tsukada
Functional Brain Mapping of the Macaque Related to Spatial Working Memory as Revealed by PET
Cereb Cortex, January 1, 2004; 14(1): 106 - 119.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
M. Remondes and E. M. Schuman
Molecular Mechanisms Contributing to Long-Lasting Synaptic Plasticity at the Temporoammonic-CA1 Synapse
Learn. Mem., July 1, 2003; 10(4): 247 - 252.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
N. Brustovetsky, T. Brustovetsky, K. J. Purl, M. Capano, M. Crompton, and J. M. Dubinsky
Increased Susceptibility of Striatal Mitochondria to Calcium-Induced Permeability Transition
J. Neurosci., June 15, 2003; 23(12): 4858 - 4867.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Davachi and A. D. Wagner
Hippocampal Contributions to Episodic Encoding: Insights From Relational and Item-Based Learning
J Neurophysiol, August 1, 2002; 88(2): 982 - 990.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
S. Heckers, D. Stone, J. Walsh, J. Shick, P. Koul, and F. M. Benes
Differential Hippocampal Expression of Glutamic Acid Decarboxylase 65 and 67 Messenger RNA in Bipolar Disorder and Schizophrenia
Arch Gen Psychiatry, June 1, 2002; 59(6): 521 - 529.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
M. C. Alvarado and J. Bachevalier
Revisiting the Maturation of Medial Temporal Lobe Memory Functions in Primates
Learn. Mem., September 1, 2000; 7(5): 244 - 256.
[Abstract] [Full Text]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-