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The Journal of Neuroscience, August 1, 2000, 20(15):5841-5847

Malformation of the Functional Organization of Somatosensory Cortex in Adult Ephrin-A5 Knock-Out Mice Revealed by In Vivo Functional Imaging

Neal Prakash¹, Pierre Vanderhaeghen², Susana Cohen-Cory³, Jonas Frisén⁴, John G. Flanagan², and Ron D. Frostig¹

¹ Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California at Irvine, Irvine, California 92697, ² Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, ³ Mental Retardation Research Center, Departments of Psychiatry and Neurobiology, University of California at Los Angeles, School of Medicine, Los Angeles, California 90095, and ⁴ Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, S-171 77 Stockholm, Sweden

The molecular mechanisms that coordinate the functional organization of the mammalian neocortex are largely unknown. We tested the involvement of a putative guidance label, ephrin-A5, in the functional organization of the somatosensory cortex by quantifying the functional representations of individual whiskers in vivo in adult ephrin-A5 knock-out mice, using intrinsic signal optical imaging. In wild-type mice ephrin-A5 is expressed in a gradient in the somatosensory cortex during development. In adult ephrin-A5 knock-out mice, we found a spatial gradient of change in the amount of cortical territory shared by individual whisker functional representations across the somatosensory cortex, as well as a gradient of change in the distance between the functional representations. Both gradients of change were in correspondence with the developmental expression gradient of ephrin-A5 in wild-type mice. These changes involved malformations of the cortical spacing of the thalamocortical components, without concurrent malformations of the intracortical components of individual whisker functional representations. Overall, these results suggest that a developmental guidance label, such as ephrin-A5, is involved in establishing certain spatial relationships of the functional organization of the adult neocortex, and they underscore the advantage of investigating gene manipulation using in vivo functional imaging.

Key words: whisker; vibrissa; barrel; posteromedial barrel subfield; intrinsic signal optical imaging; axonal guidance; thalamocortical; intracortical

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20155841-07$05.00/0

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