QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (99) Citing Articles via Google Scholar Google Scholar Articles by Horikawa, K. Articles by Shibata, S. Search for Related Content PubMed PubMed Citation Articles by Horikawa, K. Articles by Shibata, S.

 Previous Article  |  Next Article 

The Journal of Neuroscience, August 1, 2000, 20(15):5867-5873

Nonphotic Entrainment by 5-HT_1A/7 Receptor Agonists Accompanied by Reduced Per1 and Per2 mRNA Levels in the Suprachiasmatic Nuclei

Kazumasa Horikawa¹, Shin-ichi Yokota¹, Kazuyuki Fuji¹, Masashi Akiyama¹, Takahiro Moriya², Hitoshi Okamura³, and Shigenobu Shibata^{1, 2}

¹ Department of Pharmacology and Brain Science and ² Advanced Research Center for Human Sciences, School of Human Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan, and ³ Department of Anatomy and Brain Science, Kobe University School of Medicine, Chuo-ku, Kobe 650-0017, Japan

In mammals, the environmental light/dark cycle strongly synchronizes the circadian clock within the suprachiasmatic nuclei (SCN) to 24 hr. It is well known that not only photic but also nonphotic stimuli can entrain the SCN clock. Actually, many studies have shown that a daytime injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH DPAT), a serotonin 1A/7 receptor agonist, as a nonphotic stimulus induces phase advances in hamster behavioral circadian rhythms in vivo, as well as the neuron activity rhythm of the SCN in vitro. Recent reports suggest that mammalian homologs of the Drosophila clock gene, Period (Per), are involved in photic entrainment. Therefore, we examined whether phase advances elicited by 8-OH DPAT were associated with a change of Period mRNA levels in the SCN. In this experiment, we cloned partial cDNAs encoding hamster Per1, Per2, and Per3 and observed both circadian oscillation and the light responsiveness of Period. Furthermore, we found that the inhibitory effect of 8-OH DPAT on hamster Per1 and Per2 mRNA levels in the SCN occurred only during the hamster's mid-subjective day, but not during the early subjective day or subjective night. The present findings demonstrate that the acute and circadian time-dependent reduction of Per1 and/or Per2 mRNA in the hamster SCN by 8-OH DPAT is strongly correlated with the phase resetting in response to 8-OH DPAT.

Key words: suprachiasmatic nucleus; 8-OH DPAT; Per mRNA; 5-HT_1A/7 receptor; hamster; circadian rhythm; NIH Image

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/20155867-07$05.00/0

This article has been cited by other articles:

				S. J. Legan, K. M. Donoghue, K. M. Franklin, and M. J. Duncan Phenobarbital blockade of the preovulatory luteinizing hormone surge: association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period1 gene expression Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1620 - R1630. [Abstract] [Full Text] [PDF]

				A. M. Vosko, M. H. Hagenauer, D. L. Hummer, and T. M. Lee Period gene expression in the diurnal degu (Octodon degus) differs from the nocturnal laboratory rat (Rattus norvegicus) Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2009; 296(2): R353 - R361. [Abstract] [Full Text] [PDF]

				J. C. Ehlen, C. M. Novak, M. C. Karom, K. L. Gamble, and H. E. Albers Interactions of GABAA Receptor Activation and Light on Period mRNA Expression in the Suprachiasmatic Nucleus J Biol Rhythms, February 1, 2008; 23(1): 16 - 25. [Abstract] [PDF]

				E. Challet Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals Endocrinology, December 1, 2007; 148(12): 5648 - 5655. [Abstract] [Full Text] [PDF]

				U. Albrecht, A. Bordon, I. Schmutz, and J. Ripperger The Multiple Facets of Per2 Cold Spring Harb Symp Quant Biol, January 1, 2007; 72(0): 95 - 104. [Abstract] [PDF]

				H. Abe, S. Honma, and K.-i. Honma Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R607 - R615. [Abstract] [Full Text] [PDF]

				M. E. Knoch, D. Siegel, M. J. Duncan, and J. D. Glass Serotonergic mediation of constant light-potentiated nonphotic phase shifting of the circadian locomotor activity rhythm in Syrian hamsters Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R180 - R188. [Abstract] [Full Text] [PDF]

				R. E. Mistlberger Illuminating serotonergic gateways for strong resetting of the mammalian circadian clock Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2006; 291(1): R177 - R179. [Full Text] [PDF]

				C.-X. Yi, J. van der Vliet, J. Dai, G. Yin, L. Ru, and R. M. Buijs Ventromedial Arcuate Nucleus Communicates Peripheral Metabolic Information to the Suprachiasmatic Nucleus Endocrinology, January 1, 2006; 147(1): 283 - 294. [Abstract] [Full Text] [PDF]

				K. Ushijima, H. Sakaguchi, Y. Sato, H. To, S. Koyanagi, S. Higuchi, and S. Ohdo Chronopharmacological Study of Antidepressants in Forced Swimming Test of Mice J. Pharmacol. Exp. Ther., November 1, 2005; 315(2): 764 - 770. [Abstract] [Full Text] [PDF]

				T. Akagi, K. Ushinohama, S. Ikesue, E. Yukawa, S. Higuchi, K. Hamase, K. Zaitsu, and S. Ohdo Chronopharmacology of Melatonin in Mice to Maximize the Antitumor Effect and Minimize the Rhythm Disturbance Effect J. Pharmacol. Exp. Ther., January 1, 2004; 308(1): 378 - 384. [Abstract] [Full Text] [PDF]

				M. J. Vansteensel, T. Deboer, A. Dahan, and J. H. Meijer Differential Responses of Circadian Activity Onset and Offset Following GABA-ergic and Opioid Receptor Activation J Biol Rhythms, August 1, 2003; 18(4): 297 - 306. [Abstract] [PDF]

				M. C. Antle, D. K. Foley, N. C. Foley, and R. Silver Gates and Oscillators: A Network Model of the Brain Clock J Biol Rhythms, August 1, 2003; 18(4): 339 - 350. [Abstract] [PDF]

				K. Bae and D. R. Weaver Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2 J Biol Rhythms, April 1, 2003; 18(2): 123 - 133. [Abstract] [PDF]

				T. Hirota, T. Okano, K. Kokame, H. Shirotani-Ikejima, T. Miyata, and Y. Fukada Glucose Down-regulates Per1 and Per2 mRNA Levels and Induces Circadian Gene Expression in Cultured Rat-1 Fibroblasts J. Biol. Chem., November 8, 2002; 277(46): 44244 - 44251. [Abstract] [Full Text] [PDF]

				Z. Travnickova-Bendova, N. Cermakian, S. M. Reppert, and P. Sassone-Corsi Bimodal regulation of mPeriod promoters by CREB-dependent signaling and CLOCK/BMAL1 activity PNAS, May 28, 2002; 99(11): 7728 - 7733. [Abstract] [Full Text] [PDF]

				D. E. Kolker, S. Losee Olson, J. Dutton-Boilek, K. M. Bennett, E. P. Wallen, T. H. Horton, and F. W. Turek Feeding melatonin enhances the phase shifting response to triazolam in both young and old golden hamsters Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1382 - R1388. [Abstract] [Full Text] [PDF]

				A. Jovanovska and R. A. Prosser Translational and Transcriptional Inhibitors Block Serotonergic Phase Advances of the Suprachiasmatic Nucleus Circadian Pacemaker In Vitro J Biol Rhythms, April 1, 2002; 17(2): 137 - 146. [Abstract] [PDF]

				U. Albrecht Functional Genomics of Sleep and Circadian Rhythm: Invited Review: Regulation of mammalian circadian clock genes J Appl Physiol, March 1, 2002; 92(3): 1348 - 1355. [Abstract] [Full Text] [PDF]

				J. M. Brewer, P. C. Yannielli, and M. E. Harrington Neuropeptide Y Differentially Suppresses per1 and per2 mRNA Induced by Light in the Suprachiasmatic Nuclei of the Golden Hamster J Biol Rhythms, February 1, 2002; 17(1): 28 - 39. [Abstract] [PDF]

				E. D. Herzog and W. J. Schwartz Functional Genomics of Sleep and Circadian Rhythm: Invited Review: A neural clockwork for encoding circadian time J Appl Physiol, January 1, 2002; 92(1): 401 - 408. [Abstract] [Full Text] [PDF]

				N. Mrosovsky, K. Edelstein, M. H. Hastings, and E. S. Maywood Cycle of period Gene Expression in a Diurnal Mammal (Spermophilus tridecemlineatus): Implications for Nonphotic Phase Shifting J Biol Rhythms, October 1, 2001; 16(5): 471 - 478. [Abstract] [PDF]

				T. Hamada, J. LeSauter, J. M. Venuti, and R. Silver Expression of Period Genes: Rhythmic and Nonrhythmic Compartments of the Suprachiasmatic Nucleus Pacemaker J. Neurosci., October 1, 2001; 21(19): 7742 - 7750. [Abstract] [Full Text] [PDF]

				J. C. Ehlen, G. H. Grossman, and J. D. Glass In Vivo Resetting of the Hamster Circadian Clock by 5-HT7 Receptors in the Suprachiasmatic Nucleus J. Neurosci., July 15, 2001; 21(14): 5351 - 5357. [Abstract] [Full Text] [PDF]

				M. Doi, Y. Nakajima, T. Okano, and Y. Fukada Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene PNAS, June 20, 2001; (2001) 141090998. [Abstract] [Full Text] [PDF]

				U. Albrecht, B. Zheng, D. Larkin, Z. S. Sun, and C. C. Lee mPer1 and mPer2 Are Essential for Normal Resetting of the Circadian Clock J Biol Rhythms, April 1, 2001; 16(2): 100 - 104. [Abstract] [PDF]

				T. Nikaido, M. Akiyama, T. Moriya, and S. Shibata Sensitized Increase of Period Gene Expression in the Mouse Caudate/Putamen Caused by Repeated Injection of Methamphetamine Mol. Pharmacol., April 1, 2001; 59(4): 894 - 900. [Abstract] [Full Text]

				B. N. Smith, P. J. Sollars, F. E. Dudek, and G. E. Pickard Serotonergic Modulation of Retinal Input to the Mouse Suprachiasmatic Nucleus Mediated by 5-HT1B and 5-HT7 Receptors J Biol Rhythms, February 1, 2001; 16(1): 25 - 38. [Abstract] [PDF]

				M. Doi, Y. Nakajima, T. Okano, and Y. Fukada Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene PNAS, July 3, 2001; 98(14): 8089 - 8094. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help