 |
 Previous Article | Next Article 
The Journal of Neuroscience, August 15, 2000, 20(16):5906-5914
A Role for the  Isoform of Protein Kinase C in Fear
Conditioning
Edwin J.
Weeber1,
Coleen M.
Atkins1,
Joel C.
Selcher1,
Andrew W.
Varga1,
Banafsheh
Mirnikjoo1,
Richard
Paylor1, 2,
Michael
Leitges3, and
J. David
Sweatt1
1 Division of Neuroscience and 2
Department of Molecular and Human Genetics, Baylor College of Medicine,
Houston, Texas 77030, and 3 Institut for Immunbiologie,
Max Planck Institute, 79108 Freiburg, Germany
The protein kinase C family of enzymes has been implicated in
synaptic plasticity and memory in a wide range of animal species, but
to date little information has been available concerning specific roles
for individual isoforms of this category of kinases. To investigate the
role of the  isoform of PKC in mammalian learning, we characterized
mice deficient in the PKC gene using anatomical, biochemical,
physiological, and behavioral approaches. In our studies we observed
that PKC was predominantly expressed in the neocortex, in
area CA1 of the hippocampus, and in the basolateral nucleus of the
amygdala. Mice deficient in PKC showed normal brain anatomy and
normal hippocampal synaptic transmission, paired pulse facilitation,
and long-term potentiation and normal sensory and motor responses. The
PKC knock-out animals exhibited a loss of learning, however; they
suffered deficits in both cued and contextual fear conditioning. The
PKC expression pattern and behavioral phenotype in the PKC knock-out
animals indicate a critical role for the isoform of PKC in
learning-related signal transduction mechanisms, potentially in the
basolateral nucleus of the amygdala.
Key words:
PKC; Pavlovian fear conditioning; hippocampus; amygdala; knock-out; mice
Copyright © 2000 Society for Neuroscience 0270-6474/00/20165906-09$05.00/0
This article has been cited by other articles:
|
|
|
|
 
T. J. Mellott, M. T. Follettie, V. Diesl, A. A. Hill, I. Lopez-Coviella, and J. K. Blusztajn
Prenatal choline availability modulates hippocampal and cerebral cortical gene expression
FASEB J,
May 1, 2007;
21(7):
1311 - 1323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. S. Sossin
Isoform specificity of protein kinase Cs in synaptic plasticity
Learn. Mem.,
April 2, 2007;
14(4):
236 - 246.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Kuzirian, H. T. Epstein, C. J. Gagliardi, T. J. Nelson, M. Sakakibara, C. Taylor, A. B. Scioletti, and D. L. Alkon
Bryostatin Enhancement of Memory in Hermissenda
Biol. Bull.,
June 1, 2006;
210(3):
201 - 214.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. BATTAINI and A. PASCALE
Protein Kinase C Signal Transduction Regulation in Physiological and Pathological Aging
Ann. N.Y. Acad. Sci.,
December 1, 2005;
1057(1):
177 - 192.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G.-r. Zhang, X. Wang, L. Kong, X.-g. Lu, B. Lee, M. Liu, M. Sun, C. Franklin, R. G. Cook, and A. I. Geller
Genetic Enhancement of Visual Learning by Activation of Protein Kinase C Pathways in Small Groups of Rat Cortical Neurons
J. Neurosci.,
September 14, 2005;
25(37):
8468 - 8481.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Dityatev and V. Y. Bolshakov
Amygdala, Long-term Potentiation, and Fear Conditioning
Neuroscientist,
February 1, 2005;
11(1):
75 - 88.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. M. Levenson, K. J. O'Riordan, K. D. Brown, M. A. Trinh, D. L. Molfese, and J. D. Sweatt
Regulation of Histone Acetylation during Memory Formation in the Hippocampus
J. Biol. Chem.,
September 24, 2004;
279(39):
40545 - 40559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. L. Hauger, J. A. Olivares-Reyes, S. Braun, K. J. Catt, and F. M. Dautzenberg
Mediation of Corticotropin Releasing Factor Type 1 Receptor Phosphorylation and Desensitization by Protein Kinase C: A Possible Role in Stress Adaptation
J. Pharmacol. Exp. Ther.,
August 1, 2003;
306(2):
794 - 803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Weeber, Y.-H. Jiang, Y. Elgersma, A. W. Varga, Y. Carrasquillo, S. E. Brown, J. M. Christian, B. Mirnikjoo, A. Silva, A. L. Beaudet, et al.
Derangements of Hippocampal Calcium/Calmodulin-Dependent Protein Kinase II in a Mouse Model for Angelman Mental Retardation Syndrome
J. Neurosci.,
April 1, 2003;
23(7):
2634 - 2644.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. R. Birikh, E. H. Sklan, S. Shoham, and H. Soreq
Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior
PNAS,
January 7, 2003;
100(1):
283 - 288.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Rodrigues, E. P. Bauer, C. R. Farb, G. E. Schafe, and J. E. LeDoux
The Group I Metabotropic Glutamate Receptor mGluR5 Is Required for Fear Memory Formation and Long-Term Potentiation in the Lateral Amygdala
J. Neurosci.,
June 15, 2002;
22(12):
5219 - 5229.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. Weeber, M. Levy, M. J. Sampson, K. Anflous, D. L. Armstrong, S. E. Brown, J. D. Sweatt, and W. J. Craigen
The Role of Mitochondrial Porins and the Permeability Transition Pore in Learning and Synaptic Plasticity
J. Biol. Chem.,
May 17, 2002;
277(21):
18891 - 18897.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. D. Gutterman
Vascular Dysfunction in Hyperglycemia: Is Protein Kinase C the Culprit?
Circ. Res.,
January 11, 2002;
90(1):
5 - 7.
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Manseau, X. Fan, T. Hueftlein, W. S. Sossin, and V. F. Castellucci
Ca2+-Independent Protein Kinase C Apl II Mediates the Serotonin-Induced Facilitation at Depressed Aplysia Sensorimotor Synapses
J. Neurosci.,
February 15, 2001;
21(4):
1247 - 1256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. C. Selcher, T. Nekrasova, R. Paylor, G. E. Landreth, and J. D. Sweatt
Mice Lacking the ERK1 Isoform of MAP Kinase Are Unimpaired in Emotional Learning
Learn. Mem.,
January 1, 2001;
8(1):
11 - 19.
[Abstract]
[Full Text]
|
|
|
|
