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Previous Article | Next Article
The Journal of Neuroscience, August 15, 2000, 20(16):6021-6029
Neuropathology in Mice Expressing Human
-Synuclein
Herman van der Putten1, Karl-Heinz Wiederhold1, Alphonse Probst2, Samuel Barbieri1, Claudia Mistl2, Simone Danner1, Sabine Kauffmann1, Katja Hofele1, Will P. J. M. Spooren1, Markus A. Ruegg4, Shuo Lin4, Pico Caroni3, Bernd Sommer1, Markus Tolnay2, and Graeme Bilbe1 1 Nervous System Research, Novartis Pharma Inc., CH 4002 Basel, Switzerland, 2 Institute for Pathology, CH 4003 Basel, Switzerland, 3 Friedrich Miescher Institute, CH 4058 Basel, Switzerland, and 4 Biozentrum, University of Basel, CH 4056 Basel, Switzerland
The presynaptic protein
-synuclein is a prime suspect for contributing to Lewy pathology and clinical aspects of diseases, including Parkinson's disease, dementia with Lewy bodies, and a Lewy body variant of Alzheimer's disease.
Key words: transgenic mice;
Copyright © 2000 Society for Neuroscience 0270-6474/00/20166021-09$05.00/0
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