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The Journal of Neuroscience, August 15, 2000, 20(16):6241-6248
Physiological and Anatomical Organization of Multiwhisker
Response Interactions in the Barrel Cortex of Rats
Satoshi
Shimegi,
Takafumi
Akasaki,
Takehiko
Ichikawa, and
Hiromichi
Sato
School of Health and Sport Sciences, Osaka University, Toyonaka,
Osaka 560-0043, Japan
To understand the physiological properties and anatomical
organization of the spatiotemporal interaction of the responses to
multiwhisker stimulation in neurons of the rat barrel cortex, single-unit recordings of 114 neurons were performed across all layers
(layer II/III, n = 39; IV, n = 33; V/VI, n = 42) of the posteromedial barrel
subfield of the primary somatosensory cortex of anesthetized
rats. Two neighboring principal and adjacent whiskers (PW and AW,
respectively) in the same row were deflected rostrally or caudally at
varying interstimulus intervals (ISIs). In 37% of the neurons, the
response to the combined stimulus was significantly larger than the sum
of the responses to stimulation of the individual whiskers. In
instances in which response facilitation was observed, selectivity was
noted for the combination (75%) of the PW with a particular AW or for
a particular direction (60%) of whisker deflection. The direction bias
of the responses to multiwhisker stimulation was well correlated with
that of the sum of the responses to single whisker stimulation
(r = 0.83; p < 0.001). The
pattern and magnitude of the response interaction in the neurons of the superficial layers were closely related to the location of the recorded
cell in the barrel columns. Multiwhisker stimulation at short ISIs ( 3
msec) evoked prominent response facilitation in cells located close to
the border between two columns (p < 0.05, one-way ANOVA), where two excitatory inputs were expected to arrive at
the same time. Our results suggest that the spatiotemporal patterns of
multiwhisker stimulation, such as whisker combination, direction of
deflection, and timing, are expressed as different magnitudes of
response interaction, which depends on the proximity of cells to home
and adjacent barrel columns.
Key words:
somatosensory system; barrel cortex; multiwhisker
stimulation; response facilitation; stimulus specificity; spatiotemporal interaction
Copyright © 2000 Society for Neuroscience 0270-6474/00/20166241-08$05.00/0
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