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The Journal of Neuroscience, 0000, 20:RC92:1-5

RAPID COMMUNICATION
The Dynamics of Neuronal Death: A Time-Lapse Study in the Retina

Alessandro Cellerino, Lucia Galli-Resta, and Laura Colombaioni

Istituto di Neurofisiologia del Consiglio Nazionale delle Ricerche, 56017 Pisa, Italy

Using time-lapse video microscopy, we have followed the process of neuronal death in an intact region of the mammalian nervous system. We show here the fast dynamics of nuclear fragmentation, which is over in <1 hr for neurons undergoing apoptosis in the living rat retina. Nuclear fragmentation is accompanied by a progressive raise of intracellular calcium and followed by erratic movement of the apoptotic cells, documenting their loss of adhesion.

Key words: apoptosis; rat; calcium; nuclear fragmentation; pyknosis; Fluo-3

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Copyright © 0000 Society for Neuroscience  0270-6474/00/$05.00/0

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