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The Journal of Neuroscience, September 1, 2000, 20(17):6517-6528
Laminin Expression in Adult and Developing Retinae: Evidence of
Two Novel CNS Laminins
Richard T.
Libby1,
Marie-France
Champliaud2,
Thomas
Claudepierre1, 2,
Yin
Xu3,
Erin P.
Gibbons1,
Manuel
Koch2,
Robert E.
Burgeson2,
Dale D.
Hunter3, and
William J.
Brunken1, 2
1 Department of Biology, Boston College, Chestnut Hill,
Massachusetts 02467, 2 Cutaneous Biology Research Center,
Massachusetts General Hospital, Harvard Medical School, Charlestown,
Massachusetts 02129, and 3 Departments of Neuroscience,
Anatomy and Cell Biology, and Ophthalmology, Tufts University School of
Medicine, Boston, Massachusetts 02111
Components of the extracellular matrix exert myriad effects on
tissues throughout the body. In particular, the laminins, a family of
heterotrimeric extracellular glycoproteins, have been shown to affect
tissue development and integrity in such diverse organs as the kidney,
lung, skin, and nervous system. Of these, we have focused on the roles
that laminins play in the differentiation and maintenance of the
nervous system. Here, we examine the expression of all known laminin
chains within one component of the CNS, the retina. We find seven
laminin chains  3, 4, 5,  2, 3,  2, and 3outside
the retinal basement membranes. Anatomically, these chains are
coexpressed in one or both of two locations: the matrix surrounding
photoreceptors and the first synaptic layer where photoreceptors
synapse with retinal interneurons. Biochemically, four of these chains
are coisolated from retinal extracts in two independent complexes,
confirming that two novel heterotrimers423 and
523are present in the retinal matrix. During development, all four of these chains, along with components of laminin 5 (the 3,
3, and 2 chains) are also expressed at sites at which they could
exert important effects on photoreceptor development. Together, these
data suggest the existence of two novel laminin heterotrimers in the
CNS, which we term here laminin 14 (composed of the 4, 2, and
3 chains) and laminin 15 (composed of the 5, 2, and 3
chains), and lead us to hypothesize that these laminins, along with
laminin 5, may play roles in photoreceptor production, stability, and
synaptic organization.
Key words:
retina; synapse; matrix; photoreceptor; interphotoreceptor matrix; laminin
Copyright © 2000 Society for Neuroscience 0270-6474/00/20176517-12$05.00/0
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