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The Journal of Neuroscience, September 1, 2000, 20(17):6612-6618

Prefrontal Activation Evoked by Infrequent Target and Novel Stimuli in a Visual Target Detection Task: An Event-Related Functional Magnetic Resonance Imaging Study

Eiji Kirino^{1, 2}, Aysenil Belger^{1, 3}, Patricia Goldman-Rakic⁴, and Gregory McCarthy^{1, 2}

¹ Veterans Administration Medical Center, West Haven, Connecticut 06516, and Departments of ² Neurosurgery, ³ Psychiatry, and ⁴ Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510

An event-related functional magnetic resonance imaging study of prefrontal cortex was conducted during which subjects performed a visual "oddball" target detection task. Exemplars of three stimulus categories were presented at a rate of one per 1.5 sec for 10 runs, each consisting of 132 trials. Standards were color squares of varying sizes that were presented on ~92% of trials. Targets were color circles of varying sizes presented irregularly on ~4% of trials. Novels were pictures of everyday objects that were also presented irregularly on ~4% of trials. Ten subjects participated in two separate sessions in which they were required to count mentally or to push a button whenever a target appeared. Targets evoked activation within prefrontal cortex, primarily within the middle frontal gyri (MFG). This MFG activation did not differ as a function of the required response. Novels did not evoke significant activity within this region despite evidence from a separate behavioral and event-related potential study demonstrating their strong influence on processing. In additional imaging sessions with two subjects, the rules were reversed to require a button press whenever an object, but not a circle, appeared. These former novels now evoked activation in the MFG, but the former target circles did not. These experiments indicate that MFG activation is reliably evoked by exemplars from arbitrary stimulus categories that are mapped by experimental rules onto an arbitrary covert or overt response.

Key words: prefrontal cortex; P300; target detection; novelty; fMRI; visual stimuli

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20176612-07$05.00/0

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