QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Leung, H.-T. Articles by Pak, W. L. Search for Related Content PubMed PubMed Citation Articles by Leung, H.-T. Articles by Pak, W. L.

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 15, 2000, 20(18):6797-6803

Phenotypes of trpl Mutants and Interactions between the Transient Receptor Potential (TRP) and TRP-Like Channels in Drosophila

Hung-Tat Leung, Chaoxian Geng, and William L. Pak

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907-1392

The trp and trpl genes are thought to encode two classes of light-activated ion channels in Drosophila. A previous report indicated that a null trpl mutant does not display any mutant phenotype. This lack of detectable mutant phenotypes made it difficult to suggest functions for the transient receptor potential-like (TRPL) channel in photoreceptor responses. Here, the properties of trpl photoreceptor responses were studied by using electroretinogram (ERG) and intracellular recording techniques in combination with light stimuli of relatively long durations. Distinct mutant phenotypes were detectable under these conditions. These consisted of a reduced sustained component, oscillations superimposed on the response, a poststimulus hyperpolarization, and altered adaptation properties to dim background light. Comparison of photoreceptor responses obtained from wild type, trp, and trpl showed that the responses obtained from the trp and trpl null mutants did not sum up to that of the wild-type response. To explain the nonlinear summation at the peak of the response, Reuss et al. (1997) proposed that Ca²⁺ ions entering through the TRP channel modulate TRP and TRPL channel activities differentially. However, nonlinear summation was present not only at the peak but throughout the duration of response. Two lines of evidence are presented to suggest that, in addition to the interaction proposed by Reuss et al. (1997), there are other forms of interactions between TRP and TRPL channels, probably involving the channel proteins themselves.

Key words: Drosophila; phototransduction; trpl phenotypes; TRP channel; TRPL channel; channel interactions

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/20186797-07$05.00/0

This article has been cited by other articles:

				M. Parnas, B. Katz, and B. Minke Open Channel Block by Ca2+ Underlies the Voltage Dependence of Drosophila TRPL Channel J. Gen. Physiol., January 1, 2007; 129(1): 17 - 28. [Abstract] [Full Text] [PDF]

				M. A. Cronin, M.-H. Lieu, and S. Tsunoda Two stages of light-dependent TRPL-channel translocation in Drosophila photoreceptors J. Cell Sci., July 15, 2006; 119(14): 2935 - 2944. [Abstract] [Full Text] [PDF]

				T. Wang, Y. Jiao, and C. Montell Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel J. Cell Biol., November 21, 2005; 171(4): 685 - 694. [Abstract] [Full Text] [PDF]

				C. Montell TRP channels in Drosophila photoreceptor cells J. Physiol., August 15, 2005; 567(1): 45 - 51. [Abstract] [Full Text] [PDF]

				M. R. MacPherson, V. P. Pollock, L. Kean, T. D. Southall, M. E. Giannakou, K. E. Broderick, J. A. T. Dow, R. C. Hardie, and S. A. Davies Transient Receptor Potential-Like Channels Are Essential for Calcium Signaling and Fluid Transport in a Drosophila Epithelium Genetics, March 1, 2005; 169(3): 1541 - 1552. [Abstract] [Full Text] [PDF]

				C. Montell The TRP Superfamily of Cation Channels Sci. Signal., February 22, 2005; 2005(272): re3 - re3. [Abstract] [Full Text] [PDF]

				M. A. Cronin, F. Diao, and S. Tsunoda Light-dependent subcellular translocation of Gq{alpha} in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC J. Cell Sci., September 15, 2004; 117(20): 4797 - 4806. [Abstract] [Full Text] [PDF]

				V. Wolfram and M. Juusola Impact of Rearing Conditions and Short-Term Light Exposure on Signaling Performance in Drosophila Photoreceptors J Neurophysiol, September 1, 2004; 92(3): 1918 - 1927. [Abstract] [Full Text] [PDF]

				B. Minke and B. Cook TRP Channel Proteins and Signal Transduction Physiol Rev, April 1, 2002; 82(2): 429 - 472. [Abstract] [Full Text] [PDF]

				R. C. Hardie Phototransduction in Drosophila melanogaster J. Exp. Biol., March 12, 2002; 204(20): 3403 - 3409. [Abstract] [Full Text] [PDF]

				P. Lane, G. Hao, and S. S. Gross S-Nitrosylation Is Emerging as a Specific and Fundamental Posttranslational Protein Modification: Head-to-Head Comparison with O-Phosphorylation Sci. Signal., June 12, 2001; 2001(86): re1 - re1. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help