 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, September 15, 2000, 20(18):6927-6938
Local Permutations in the Glomerular Array of the Mouse Olfactory Bulb
Jörg Strotmann1, 2, Sidonie Conzelmann2, Anja Beck2, Paul Feinstein1, Heinz Breer2, and Peter Mombaerts1 1 The Rockefeller University, New York, New York 10021, and 2 Institute of Physiology, University Stuttgart-Hohenheim, D-70593 Stuttgart, Germany
Olfactory sensory neurons expressing a given odorant receptor gene project their axons with great precision to a few specific glomeruli in the olfactory bulb. It is not clear to which extent the positions of these glomeruli are fixed. We sought to evaluate the constancy of the glomerular array in the mouse by determining the relative positions of glomeruli for various odorant receptors, using a method that affords single-axon resolution, and in a large number of bulbs. We used a genetic strategy to visualize neuronal populations that express one of three members of the mOR37 subfamily. We generated by gene targeting five strains of mice in which expression of a given mOR37 gene is linked to expression of an axonal maker, which is either taulacZ or tauGFP. The patterns of marker expression faithfully mimic those of the cognate receptors. Axons of neurons expressing a given mOR37 gene converge onto one or two glomeruli per bulb. Each mOR37 gene has its own glomeruli, and the mOR37 glomeruli are grouped within a restricted domain of the bulb. Serial sectioning of 214 bulbs reveals that the relative positions of the three types of glomeruli are not fixed but display local permutations. Importantly, this is also the case among the two bulbs from one individual, ruling out the genetic manipulation itself and differences in genetic background or olfactory experience as causes for the observed variability. These local permutations may reflect the developmental history of the glomeruli and are relevant for the construction of spatial odor maps.
Key words: olfaction; olfactory system; olfactory bulb; glomerulus; sensory neuron; olfactory receptor; odorant receptor
Copyright © 2000 Society for Neuroscience 0270-6474/00/20186927-12$05.00/0
This article has been cited by other articles:
H. B. Treloar, A. Ray, L. A. Dinglasan, M. Schachner, and C. A. Greer
Tenascin-C Is an Inhibitory Boundary Molecule in the Developing Olfactory Bulb
J. Neurosci., July 29, 2009; 29(30): 9405 - 9416.
[Abstract] [Full Text] [PDF]
J. C. McIntyre, S. C. Bose, A. J. Stromberg, and T. S. McClintock
Emx2 Stimulates Odorant Receptor Gene Expression
Chem Senses, November 1, 2008; 33(9): 825 - 837.
[Abstract] [Full Text] [PDF]
I. Manzini, C. Brase, T.-W. Chen, and D. Schild
Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis
J. Physiol., June 1, 2007; 581(2): 567 - 579.
[Abstract] [Full Text] [PDF]
A. A. Nikonov and J. Caprio
Responses of Olfactory Forebrain Units to Amino Acids in the Channel Catfish
J Neurophysiol, March 1, 2007; 97(3): 2490 - 2498.
[Abstract] [Full Text] [PDF]
K. Mori, Y. K. Takahashi, K. M. Igarashi, and M. Yamaguchi
Maps of Odorant Molecular Features in the Mammalian Olfactory Bulb
Physiol Rev, April 1, 2006; 86(2): 409 - 433.
[Abstract] [Full Text] [PDF]
M. Spehr, K. R. Kelliher, X.-H. Li, T. Boehm, T. Leinders-Zufall, and F. Zufall
Essential Role of the Main Olfactory System in Social Recognition of Major Histocompatibility Complex Peptide Ligands
J. Neurosci., February 15, 2006; 26(7): 1961 - 1970.
[Abstract] [Full Text] [PDF]
T. A. Schoenfeld and T. A. Cleland
Anatomical Contributions to Odorant Sampling and Representation in Rodents: Zoning in on Sniffing Behavior
Chem Senses, February 1, 2006; 31(2): 131 - 144.
[Abstract] [Full Text] [PDF]
H. Spors, M. Wachowiak, L. B. Cohen, and R. W. Friedrich
Temporal Dynamics and Latency Patterns of Receptor Neuron Input to the Olfactory Bulb
J. Neurosci., January 25, 2006; 26(4): 1247 - 1259.
[Abstract] [Full Text] [PDF]
E. Salcedo, C. Zhang, E. Kronberg, and D. Restrepo
Analysis of Training-Induced Changes in Ethyl Acetate Odor Maps Using a New Computational Tool to Map the Glomerular Layer of the Olfactory Bulb
Chem Senses, September 1, 2005; 30(7): 615 - 626.
[Abstract] [Full Text] [PDF]
J. Li, J. A. Mack, M. Souren, E. Yaksi, S.-i. Higashijima, M. Mione, J. R. Fetcho, and R. W. Friedrich
Early Development of Functional Spatial Maps in the Zebrafish Olfactory Bulb
J. Neurosci., June 15, 2005; 25(24): 5784 - 5795.
[Abstract] [Full Text] [PDF]
K. M. Igarashi and K. Mori
Spatial Representation of Hydrocarbon Odorants in the Ventrolateral Zones of the Rat Olfactory Bulb
J Neurophysiol, February 1, 2005; 93(2): 1007 - 1019.
[Abstract] [Full Text] [PDF]
Y. K. Takahashi, M. Kurosaki, S. Hirono, and K. Mori
Topographic Representation of Odorant Molecular Features in the Rat Olfactory Bulb
J Neurophysiol, October 1, 2004; 92(4): 2413 - 2427.
[Abstract] [Full Text] [PDF]
J. Strotmann, O. Levai, J. Fleischer, K. Schwarzenbacher, and H. Breer
Olfactory Receptor Proteins in Axonal Processes of Chemosensory Neurons
J. Neurosci., September 1, 2004; 24(35): 7754 - 7761.
[Abstract] [Full Text] [PDF]
A. A. Nikonov and J. Caprio
Odorant Specificity of Single Olfactory Bulb Neurons to Amino Acids in the Channel Catfish
J Neurophysiol, July 1, 2004; 92(1): 123 - 134.
[Abstract] [Full Text] [PDF]
S. S. Wang, J. W. Lewcock, P. Feinstein, P. Mombaerts, and R. R. Reed
Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection
Development, March 15, 2004; 131(6): 1377 - 1388.
[Abstract] [Full Text] [PDF]
C. L. Iwema, H. Fang, D. B. Kurtz, S. L. Youngentob, and J. E. Schwob
Odorant Receptor Expression Patterns Are Restored in Lesion-Recovered Rat Olfactory Epithelium
J. Neurosci., January 14, 2004; 24(2): 356 - 369.
[Abstract] [Full Text] [PDF]
R. Hoppe, H. Frank, H. Breer, and J. Strotmann
The Clustered Olfactory Receptor Gene Family 262: Genomic Organization, Promotor Elements, and Interacting Transcription Factors
Genome Res., December 1, 2003; 13(12): 2674 - 2685.
[Abstract] [Full Text] [PDF]
A. Hansen, S. H. Rolen, K. Anderson, Y. Morita, J. Caprio, and T. E. Finger
Correlation between Olfactory Receptor Cell Type and Function in the Channel Catfish
J. Neurosci., October 15, 2003; 23(28): 9328 - 9339.
[Abstract] [Full Text] [PDF]
F. Xu, N. Liu, I. Kida, D. L. Rothman, F. Hyder, and G. M. Shepherd
Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb
PNAS, September 16, 2003; 100(19): 11029 - 11034.
[Abstract] [Full Text] [PDF]
M. Alenius and S. Bohm
Differential function of RNCAM isoforms in precise target selection of olfactory sensory neurons
Development, March 1, 2003; 130(5): 917 - 927.
[Abstract] [Full Text] [PDF]
B. Goetze, H. Breer, and J. Strotmann
A Long-term Culture System for Olfactory Explants with Intrinsically Fluorescent Cell Populations
Chem Senses, November 1, 2002; 27(9): 817 - 824.
[Abstract] [Full Text] [PDF]
M. L. Schaefer, K. Yamazaki, K. Osada, D. Restrepo, and G. K. Beauchamp
Olfactory Fingerprints for Major Histocompatibility Complex-Determined Body Odors II: Relationship among Odor Maps, Genetics, Odor Composition, and Behavior
J. Neurosci., November 1, 2002; 22(21): 9513 - 9521.
[Abstract] [Full Text] [PDF]
M. Kaschube, F. Wolf, T. Geisel, and S. Lowel
Genetic Influence on Quantitative Features of Neocortical Architecture
J. Neurosci., August 15, 2002; 22(16): 7206 - 7217.
[Abstract] [Full Text] [PDF]
H. B. Treloar, P. Feinstein, P. Mombaerts, and C. A. Greer
Specificity of Glomerular Targeting by Olfactory Sensory Axons
J. Neurosci., April 1, 2002; 22(7): 2469 - 2477.
[Abstract] [Full Text] [PDF]
B. Key and J. St John
Axon Navigation in the Mammalian Primary Olfactory Pathway: Where to Next?
Chem Senses, March 1, 2002; 27(3): 245 - 260.
[Abstract] [Full Text] [PDF]
H. U. Fried, S. H. Fuss, and S. I. Korsching
Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli
PNAS, February 14, 2002; (2002) 52658399.
[Abstract] [Full Text] [PDF]
S. M. Potter, C. Zheng, D. S. Koos, P. Feinstein, S. E. Fraser, and P. Mombaerts
Structure and Emergence of Specific Olfactory Glomeruli in the Mouse
J. Neurosci., December 15, 2001; 21(24): 9713 - 9723.
[Abstract] [Full Text] [PDF]
C. Linster, B. A. Johnson, E. Yue, A. Morse, Z. Xu, E. E. Hingco, Y. Choi, M. Choi, A. Messiha, and M. Leon
Perceptual Correlates of Neural Representations Evoked by Odorant Enantiomers
J. Neurosci., December 15, 2001; 21(24): 9837 - 9843.
[Abstract] [Full Text] [PDF]
S. H. Fuss and S. I. Korsching
Odorant Feature Detection: Activity Mapping of Structure Response Relationships in the Zebrafish Olfactory Bulb
J. Neurosci., November 1, 2001; 21(21): 8396 - 8407.
[Abstract] [Full Text] [PDF]
M. Pyrski, Z. Xu, E. Walters, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, and F. L. Margolis
The OMP-lacZ Transgene Mimics the Unusual Expression Pattern of OR-Z6, a New Odorant Receptor Gene on Mouse Chromosome 6: Implication for Locus-Dependent Gene Expression
J. Neurosci., July 1, 2001; 21(13): 4637 - 4648.
[Abstract] [Full Text] [PDF]
M. L. Schaefer, D. A. Young, and D. Restrepo
Olfactory Fingerprints for Major Histocompatibility Complex-Determined Body Odors
J. Neurosci., April 1, 2001; 21(7): 2481 - 2487.
[Abstract] [Full Text] [PDF]
L. Belluscio and L. C. Katz
Symmetry, Stereotypy, and Topography of Odorant Representations in Mouse Olfactory Bulbs
J. Neurosci., March 15, 2001; 21(6): 2113 - 2122.
[Abstract] [Full Text] [PDF]
H. U. Fried, S. H. Fuss, and S. I. Korsching
Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli
PNAS, March 5, 2002; 99(5): 3222 - 3227.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|