 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, September 15, 2000, 20(18):7017-7023
The Role of Identified Neurotransmitter Systems in the Response of Insular Cortex to Unfamiliar Taste: Activation of ERK1-2 and Formation of a Memory Trace
Diego E. Berman, Shoshi Hazvi, Victor Neduva, and Yadin Dudai Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
In the behaving rat, the consumption of an unfamiliar taste activates the extracellular signal-regulated kinase 1-2 (ERK1-2) in the insular cortex, which contains the taste cortex. In contrast, consumption of a familiar taste has no effect. Furthermore, activation of ERK1-2, culminating in modulation of gene expression, is obligatory for the encoding of long-term, but not short-term, memory of the new taste (Berman et al., 1998). Which neurotransmitter and neuromodulatory systems are involved in the activation of ERK1-2 by the unfamiliar taste and in the long-term encoding of the new taste information? Here we show, by the use of local microinjections of pharmacological agents to the insular cortex in the behaving rat, that multiple neurotransmitters and neuromodulators are required for encoding of taste memory in cortex. However, these systems vary in the specificity of their role in memory acquisition and in their contribution to the activation of ERK1-2. NMDA receptors, metabotropic glutamate receptors, muscarinic, and
-adrenergic and dopaminergic receptors, all contribute to the acquisition of the new taste memory but not to its retrieval. Among these, only NMDA and muscarinic receptors specifically mediate taste-dependent activation of ERK1-2, whereas the
Key words: memory; novelty; taste; acetylcholine; glutamate; MAPK
Copyright © 2000 Society for Neuroscience 0270-6474/00/20187017-07$05.00/0
This article has been cited by other articles:
I. Balderas, C. J. Rodriguez-Ortiz, P. Salgado-Tonda, J. Chavez-Hurtado, J. L. McGaugh, and F. Bermudez-Rattoni
The consolidation of object and context recognition memory involve different regions of the temporal lobe
Learn. Mem., August 21, 2008; 15(9): 618 - 624.
[Abstract] [Full Text] [PDF]
K. Preuschoff, S. R. Quartz, and P. Bossaerts
Human Insula Activation Reflects Risk Prediction Errors As Well As Risk
J. Neurosci., March 12, 2008; 28(11): 2745 - 2752.
[Abstract] [Full Text] [PDF]
R. Accolla and A. Carleton
Internal body state influences topographical plasticity of sensory representations in the rat gustatory cortex
PNAS, March 11, 2008; 105(10): 4010 - 4015.
[Abstract] [Full Text] [PDF]
W.-Y. Ho, P.-J. Lu, M. Hsiao, H.-R. Hwang, Y.-C. Tseng, M.-H. Yen, and C.-J. Tseng
Adenosine Modulates Cardiovascular Functions Through Activation of Extracellular Signal-Regulated Kinases 1 and 2 and Endothelial Nitric Oxide Synthase in the Nucleus Tractus Solitarii of Rats
Circulation, February 12, 2008; 117(6): 773 - 780.
[Abstract] [Full Text] [PDF]
A. Bahar, Y. Dudai, and E. Ahissar
Neural Signature of Taste Familiarity in the Gustatory Cortex of the Freely Behaving Rat
J Neurophysiol, December 1, 2004; 92(6): 3298 - 3308.
[Abstract] [Full Text] [PDF]
H.-Y. Cheng and D. F. Clayton
Activation and Habituation of Extracellular Signal-Regulated Kinase Phosphorylation in Zebra Finch Auditory Forebrain during Song Presentation
J. Neurosci., August 25, 2004; 24(34): 7503 - 7513.
[Abstract] [Full Text] [PDF]
M. I. Miranda and J. L. McGaugh
Enhancement of Inhibitory Avoidance and Conditioned Taste Aversion Memory With Insular Cortex Infusions of 8-Br-cAMP: Involvement of the Basolateral Amygdala
Learn. Mem., May 1, 2004; 11(3): 312 - 317.
[Abstract] [Full Text] [PDF]
S. G. Walling and C. W. Harley
Locus Ceruleus Activation Initiates Delayed Synaptic Potentiation of Perforant Path Input to the Dentate Gyrus in Awake Rats: A Novel {beta}-Adrenergic- and Protein Synthesis-Dependent Mammalian Plasticity Mechanism
J. Neurosci., January 21, 2004; 24(3): 598 - 604.
[Abstract] [Full Text] [PDF]
R. Gutierrez, V. De la Cruz, C. J. Rodriguez-Ortiz, and F. Bermudez-Rattoni
Perirhinal Cortex Muscarinic Receptor Blockade Impairs Taste Recognition Memory Formation
Learn. Mem., January 1, 2004; 11(1): 95 - 101.
[Abstract] [Full Text] [PDF]
A. Desmedt, S. Hazvi, and Y. Dudai
Differential Pattern of cAMP Response Element-Binding Protein Activation in the Rat Brain after Conditioned Aversion as a Function of the Associative Process Engaged: Taste versus Context Association
J. Neurosci., July 9, 2003; 23(14): 6102 - 6110.
[Abstract] [Full Text] [PDF]
D. E. Berman, S. Hazvi, J. Stehberg, A. Bahar, and Y. Dudai
Conflicting Processes in the Extinction of Conditioned Taste Aversion: Behavioral and Molecular Aspects of Latency, Apparent Stagnation, and Spontaneous Recovery
Learn. Mem., January 1, 2003; 10(1): 16 - 25.
[Abstract] [Full Text] [PDF]
M. W. Swank and J. D. Sweatt
Increased Histone Acetyltransferase and Lysine Acetyltransferase Activity and Biphasic Activation of the ERK/RSK Cascade in Insular Cortex During Novel Taste Learning
J. Neurosci., May 15, 2001; 21(10): 3383 - 3391.
[Abstract] [Full Text] [PDF]
D. E. Berman and Y. Dudai
Memory Extinction, Learning Anew, and Learning the New: Dissociations in the Molecular Machinery of Learning in Cortex
Science, March 23, 2001; 291(5512): 2417 - 2419.
[Abstract] [Full Text]
|
|
|
|
 |
|