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The Journal of Neuroscience, January 15, 2000, 20(2):579-588
Kv4.2 mRNA Abundance and A-Type K+ Current Amplitude Are Linearly Related in Basal Ganglia and Basal Forebrain Neurons
Tatiana Tkatch, Gytis Baranauskas, and D. James Surmeier Department of Physiology and Institute for Neuroscience, Northwestern University Medical School, Chicago, Illinois 60611
A-type K+ currents are key determinants of repetitive activity and synaptic integration. Although several gene families have been shown to code for A-type channel subunits, recent studies have suggested that Kv4 family channels are the principal contributors to A-type channels in the somatodendritic membrane of mammalian brain neurons. If this hypothesis is correct, there should be a strong correlation between Kv4 family mRNA and A-type channel protein or aggregate channel currents. To test this hypothesis, quantitative single-cell reverse transcription-PCR analysis of Kv4 family mRNA was combined with voltage-clamp analysis of A-type K+ currents in acutely isolated neurons. These studies revealed that Kv4.2 mRNA abundance was linearly related to A-type K+ current amplitude in neostriatal medium spiny neurons and cholinergic interneurons, in globus pallidus neurons, and in basal forebrain cholinergic neurons. In contrast, there was not a significant correlation between estimates of Kv4.1 or Kv4.3 mRNA abundance and A-type K+ current amplitudes. These results argue that Kv4.2 subunits are major constituents of somatodendritic A-type K+ channels in these four types of neuron. In spite of this common structural feature, there were significant differences in the voltage dependence and kinetics of A-type currents in the cell types studied, suggesting that other determinants may create important functional differences between A-type K+ currents.
Key words: Kv4; A-type K+ channel; voltage clamp; single-cell RT-PCR; TEA; 4-AP; potassium channels; mRNA
Copyright © 2000 Society for Neuroscience 0270-6474/00/202579-10$05.00/0
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