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The Journal of Neuroscience, January 15, 2000, 20(2):845-853

Comparison of the Laminar Distribution of Input from Areas 17 and 18 of the Visual Cortex to the Lateral Geniculate Nucleus of the Cat

P. C. Murphy^{1, 2}, S. G. Duckett¹, and A. M. Sillito²

¹ Department of Physiology, St. George's Hospital Medical School, Tooting, London SW17 0RE, United Kingdom, and ² Department of Visual Science, Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom

The feedback from area 18 of the cat visual cortex to the lateral geniculate nucleus has been investigated by labeling and reconstructing seventeen axons of known receptive field position and eye preference. The distribution of boutons from each axon was quantified with respect to the compartments of the geniculate complex, and the results were compared with an equivalent analysis of fourteen area 17 axons. Area 18 axons form large, sparse arborizations that extend up to 1.9 mm laterally (1170 ± 85 µm; mean ± SEM), with a core of relatively dense innervation spanning on average 600 ± 70 µm (mean ± SEM). Thus, they have the potential to influence the transmission of visual information from well beyond their own classical receptive fields. In this respect, they are surprisingly similar to the axons from area 17, despite the fact that the two cortical areas have very different retinotopy. However, there are important differences between the pathways. Area 18 axons project more heavily to the C layers and medial interlaminar nucleus. Whereas the input from both areas to the A layers is biased toward the layer appropriate to the eye preference of each axon, the area 18 input to magnocellular layer C is not. The distribution of area 18 boutons favors the bottom of their preferred A layer, and the area 17 boutons favor the top. These differences mirror those seen in the afferent pathways, suggesting that each cortical area preferentially targets the cells from which it receives input. Finally, their greater diameter suggests that area 18 axons provide the earliest feedback signal in the corticogeniculate loop.

Key words: lateral geniculate nucleus; visual cortex; corticofugal feedback; functional connectivity; ocular dominance; visual responses

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Copyright © 2000 Society for Neuroscience  0270-6474/00/202845-09$05.00/0

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