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The Journal of Neuroscience, November 1, 2000, 20(21):8218-8226

Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Inferior Olive

Daniel A. Nicholson and John H. Freeman Jr

Department of Psychology, University of Iowa, Iowa City, Iowa 52242

Neuronal activity was recorded in the dorsal accessory inferior olive in infant rats during classical conditioning of the eye-blink response. The percentage and amplitude of eye-blink conditioned responses (CRs) increased as a function of age. The magnitude of the neuronal response to the unconditioned stimulus (US) decreased with age. There were also age-specific modifications of US-elicited inferior olive neuronal activity during paired trials in which a conditioned eye-blink response was performed. The results indicate that the development of the conditioned eye-blink response may depend on dynamic interactions between multiple developmental processes within the eye-blink circuitry. Differences in the functional maturity of olivo-cerebellar pathways may limit the induction of plasticity in the cerebellum and thereby limit the development of eye-blink conditioned responses.

Key words: ontogeny; brainstem; olive; learning; conditioning; eyeblink

Copyright © 2000 Society for Neuroscience  0270-6474/00/20218218-09$05.00/0


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