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The Journal of Neuroscience, 0000, 20:RC113:1-5

RAPID COMMUNICATION
Electrical Coupling and Excitatory Synaptic Transmission between Rhythmogenic Respiratory Neurons in the PreBötzinger Complex

Jens C. Rekling, Xuesi M. Shao, and Jack L. Feldman

Department of Neurobiology, University of California, Los Angeles, Los Angeles, California 90095-1763

Breathing pattern is postulated to be generated by brainstem neurons. However, determination of the underlying cellular mechanisms, and in particular the synaptic interactions between respiratory neurons, has been difficult. Here we used dual recordings from two distinct populations of brainstem respiratory neurons, hypoglossal (XII) motoneurons, and rhythmogenic (type-1) neurons in the preBötzinger complex (preBötC), the hypothesized site for respiratory rhythm generation, to determine whether electrical and chemical transmission is present. Using an in vitro brainstem slice preparation from newborn mice, we found that intracellularly recorded pairs of XII motoneurons and pairs of preBötC inspiratory type-1 neurons showed bidirectional electrical coupling. Coupling strength was low (<0.10), and the current that passed between two neurons was heavily filtered (corner frequency, <10 Hz). Dual recordings also demonstrated unidirectional excitatory chemical transmission (EPSPs of ~3 mV) between type-1 neurons. These data indicate that respiratory motor output from the brainstem involves gap junction-mediated current transfer between motoneurons. Furthermore, bidirectional electrical coupling and unidirectional excitatory chemical transmission are present between type-1 neurons in the preBötC and may be important for generation or modulation of breathing rhythm.

Key words: respiration; preBötzinger complex; type-1 neurons; respiratory rhythmogenesis; electrical coupling; excitatory transmission; newborn mice

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Copyright © 0000 Society for Neuroscience  0270-6474/00/$05.00/0

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