 |
||||
|
||||
|
||||
|
||||
.gif?ad=17923&adview=true)
Previous Article | Next Article
The Journal of Neuroscience, December 15, 2000, 20(24):9252-9263
Discharge Profiles of Juxtacellularly Labeled and Immunohistochemically Identified GABAergic Basal Forebrain Neurons Recorded in Association with the Electroencephalogram in Anesthetized Rats
Ian D. Manns, Angel Alonso, and Barbara E. Jones Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
The basal forebrain ostensibly plays a dual role in the modulation of cortical activation and behavioral state. It is essential for stimulating cortical activation in association with waking (and paradoxical sleep), yet also important for attenuating cortical activation and promoting slow wave sleep. Using juxtacellular recording and labeling of neurons with Neurobiotin followed by immunohistochemical staining for glutamic acid decarboxylase (GAD), we studied the discharge properties of identified GABAergic basal forebrain neurons in relation to electroencephalographic (EEG) activity in urethane-anesthetized rats to determine the part or parts that they may play in this dual role.
The GABAergic neurons displayed distinct discharge profiles in relation to somatosensory stimulation-evoked cortical activation. Whereas a significant minority increased its average discharge rate, the majority decreased its average discharge rate in association with cortical activation. Moreover, subgroups displayed distinct discharge patterns related to different cortical activities, including very regular high-frequency tonic spiking within a gamma EEG frequency range and rhythmic cluster spiking within a theta-like frequency range during cortical activation. During irregular slow EEG activity in absence of stimulation, one subgroup displayed spike bursts correlated with cortical slow oscillations. As relatively large in size and also antidromically activated from the cortex, many GABAergic neurons recorded were considered to be cortically projecting and thus capable of directly modulating cortical activity. Subgroups of GABAergic basal forebrain neurons would thus have the capacity to promote cortical activation by modulating gamma or theta activity and others to attenuate cortical activation by modulating irregular slow oscillations that normally occur during slow wave sleep.
Key words: juxtacellular labeling; gamma; paradoxical sleep; slow wave sleep; theta; waking
Copyright © 2000 Society for Neuroscience 0270-6474/00/20249252-12$05.00/0
This article has been cited by other articles:
S. Kaur, A. Junek, M. A. Black, and K. Semba
Effects of Ibotenate and 192IgG-Saporin Lesions of the Nucleus Basalis Magnocellularis/Substantia Innominata on Spontaneous Sleep and Wake States and on Recovery Sleep after Sleep Deprivation in Rats
J. Neurosci., January 9, 2008; 28(2): 491 - 504.
[Abstract] [Full Text] [PDF]
T. Momiyama and L. Zaborszky
Somatostatin Presynaptically Inhibits Both GABA and Glutamate Release Onto Rat Basal Forebrain Cholinergic Neurons
J Neurophysiol, August 1, 2006; 96(2): 686 - 694.
[Abstract] [Full Text] [PDF]
M. E. Hasselmo
A Model of Prefrontal Cortical Mechanisms for Goal-directed Behavior
J. Cogn. Neurosci., July 1, 2005; 17(7): 1115 - 1129.
[Abstract] [Full Text] [PDF]
M. G. Lee, I. D. Manns, A. Alonso, and B. E. Jones
Sleep-Wake Related Discharge Properties of Basal Forebrain Neurons Recorded With Micropipettes in Head-Fixed Rats
J Neurophysiol, August 1, 2004; 92(2): 1182 - 1198.
[Abstract] [Full Text] [PDF]
I. D. Manns, A. Alonso, and B. E. Jones
Rhythmically Discharging Basal Forebrain Units Comprise Cholinergic, GABAergic, and Putative Glutamatergic Cells
J Neurophysiol, February 1, 2003; 89(2): 1057 - 1066.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|