 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, December 15, 2000, 20(24):9264-9271
Reduced Rearing Temperature Augments Responses in Sympathetic Outflow to Brown Adipose Tissue
Shaun F. Morrison1, Sheela Ramamurthy1, and James B. Young2 Departments of 1 Physiology and 2 Medicine, Northwestern University Medical School, Chicago, Illinois 60611
Sympathetic outflow to brown adipose tissue (BAT) contributes to both thermoregulation and energy expenditure in rats through regulation of BAT thermogenesis. Acute cold exposure in mature animals augments BAT thermogenesis; however, the enhanced BAT thermogenic response returns to normal shortly after cessation of the cold exposure. In this study, we sought to determine whether cold exposure in early neonatal life could induce enhanced responses in the sympathetic outflow to BAT and whether this altered sympathetic regulation would be sustained after the cold stimulus was removed. BAT sympathetic nerve activity (SNA) was recorded in urethane-chloralose-anesthetized, artificially ventilated rats that were raised from birth in either 18 or 30°C environments and then, at 8 weeks of age, were maintained in 23°C for at least 4 weeks. An acute hypothermic stimulus, disinhibition of a brainstem thermogenic network in the raphe pallidus, or electrical stimulation in this raphe site produced increases in BAT SNA that were twice as great in rats reared at 18°C as in those reared at 30°C. The norepinephrine content of the interscapular BAT (IBAT) and the number of sympathetic ganglion cells projecting to interscapular BAT were 70% greater in the 18°C-reared rats. We conclude that neonatal exposure to a cold environment induces a permanent developmental alteration in the capacity for sympathetic stimulation of BAT thermogenesis that may be mediated, in part, by a greater number of sympathetic ganglion cells innervating BAT in cold-reared animals.
Key words: raphe pallidus; sympathetic ganglion; sympathetic development; brown adipose tissue; thermogenesis; cold acclimation; bicuculline; fast blue
Copyright © 2000 Society for Neuroscience 0270-6474/00/20249264-08$05.00/0
This article has been cited by other articles:
M. Sun, C. J. Lee, and H.-S. Shin
Reduced nicotinic receptor function in sympathetic ganglia is responsible for the hypothermia in the acetylcholinesterase knockout mouse
J. Physiol., February 1, 2007; 578(3): 751 - 764.
[Abstract] [Full Text] [PDF]
Y. Ootsuka and R. M. McAllen
Comparison between two rat sympathetic pathways activated in cold defense
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R589 - R595.
[Abstract] [Full Text] [PDF]
J. L. Segar, R. D. Roghair, E. M. Segar, M. C. Bailey, T. D. Scholz, and F. S. Lamb
Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs before hypertension
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R481 - R488.
[Abstract] [Full Text] [PDF]
R. M. McAllen, M. Farrell, J. M. Johnson, D. Trevaks, L. Cole, M. J. McKinley, G. Jackson, D. A. Denton, and G. F. Egan
Human medullary responses to cooling and rewarming the skin: A functional MRI study
PNAS, January 17, 2006; 103(3): 809 - 813.
[Abstract] [Full Text] [PDF]
C. J Madden and S. F Morrison
Hypoxic activation of arterial chemoreceptors inhibits sympathetic outflow to brown adipose tissue in rats
J. Physiol., July 15, 2005; 566(2): 559 - 573.
[Abstract] [Full Text] [PDF]
C. L. White, H. D. Braymer, D. A. York, and G. A. Bray
Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1376 - R1384.
[Abstract] [Full Text] [PDF]
W. W. Blessing
BAT control shows the way: medullary raphe/parapyramidal neurons and sympathetic regulation of brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R557 - R560.
[Full Text] [PDF]
S. J. Swoap, J. M. Overton, and G. Garber
Effect of ambient temperature on cardiovascular parameters in rats and mice: a comparative approach
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R391 - R396.
[Abstract] [Full Text] [PDF]
S. F. Morrison
Central Pathways Controlling Brown Adipose Tissue Thermogenesis
Physiology, April 1, 2004; 19(2): 67 - 74.
[Abstract] [Full Text] [PDF]
R. R. Vollmer and O. Skott
Rearing temperature and the sympathetic nervous system regulation of white and brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1196 - R1197.
[Full Text] [PDF]
J. B. Young, J. Weiss, and N. Boufath
Effects of rearing temperature on sympathoadrenal activity in young adult rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1198 - R1209.
[Abstract] [Full Text] [PDF]
J. B. Young
Effects of litter size on sympathetic activity in young adult rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1113 - R1121.
[Abstract] [Full Text] [PDF]
B. C. Samuels, D. V. Zaretsky, and J. A. DiMicco
Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe
J. Physiol., February 1, 2002; 538(3): 941 - 946.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|