 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, February 1, 2000, 20(3):1142-1156
Do Centrally Administered Neuropeptides Access Cognate Receptors?: An Analysis in the Central Corticotropin-Releasing Factor System
Jackson C. Bittencourt and Paul E. Sawchenko Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies and Foundation for Medical Research, La Jolla, California 92037
To determine the extent to which centrally administered corticotropin-releasing factor (CRF) activates neurons that express CRF receptors (CRF-Rs), we followed the kinetics and distribution (relative to those of CRF-Rs) of Fos induction seen in response to intracerebroventricular (icv) injection of the peptide (1-10 µg). CRF provoked widespread Fos expression: its strength was dose-related, it peaked at 2 hr after injection, and it was antagonized in a dose-dependent manner by coinjection of CRF-R antagonists. The activation pattern closely mimicked the distribution of CRF-R1 mRNA, in including widespread Fos induction throughout the cortical mantle, in cell groups involved in sensory information processing, and in the cerebellum and several of its major afferents and targets. Dual labeling revealed extensive correspondence of CRF-stimulated Fos-immunoreactivity (Fos-ir) and CRF-R1 mRNA at these and other loci. Unique sites of CRF-R2 expression were relatively unresponsive to CRF but were more so after icv administration of urocortin (UCN), a new mammalian CRF-related peptide. Both CRF and UCN elicited activational responses in cell groups that are involved in central autonomic control but that express neither CRF-R, including the central amygdaloid and paraventricular hypothalamic nuclei, and brainstem catecholaminergic cell groups. The results support an ability of CRF-related peptides in the ventricular system to access receptor-expressing cells directly but leave open questions as to the basis for the recruitment of central autonomic structures, many of which have been identified as stress-related sites of CRF action.
Key words: corticotropin-releasing factor; corticotropin-releasing factor receptors; fos; intracerebroventricular injections; neuropeptides; stress; urocortin
Copyright © 2000 Society for Neuroscience 0270-6474/00/2031142-15$05.00/0
This article has been cited by other articles:
J. Xu, F. Xu, J. D. Hennebold, T. A. Molskness, and R. L. Stouffer
Expression and Role of the Corticotropin-Releasing Hormone/Urocortin-Receptor-Binding Protein System in the Primate Corpus Luteum during the Menstrual Cycle
Endocrinology, November 1, 2007; 148(11): 5385 - 5395.
[Abstract] [Full Text] [PDF]
R. A. Rissman, K.-F. Lee, W. Vale, and P. E. Sawchenko
Corticotropin-Releasing Factor Receptors Differentially Regulate Stress-Induced Tau Phosphorylation
J. Neurosci., June 13, 2007; 27(24): 6552 - 6562.
[Abstract] [Full Text] [PDF]
T. Gallopin, H. Geoffroy, J. Rossier, and B. Lambolez
Cortical Sources of CRF, NKB, and CCK and Their Effects on Pyramidal Cells in the Neocortex
Cereb Cortex, October 1, 2006; 16(10): 1440 - 1452.
[Abstract] [Full Text] [PDF]
J. Xu, J. D. Hennebold, and R. L. Stouffer
Dynamic Expression and Regulation of the Corticotropin-Releasing Hormone/Urocortin-Receptor-Binding Protein System in the Primate Ovary during the Menstrual Cycle
J. Clin. Endocrinol. Metab., April 1, 2006; 91(4): 1544 - 1553.
[Abstract] [Full Text] [PDF]
P. L. Seymour, S. L. Dettloff, J. E. Jones, and G. N. Wade
Corticotropin-releasing factor receptor subtypes mediating nutritional suppression of estrous behavior in Syrian hamsters
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2005; 289(2): R418 - R423.
[Abstract] [Full Text] [PDF]
D.-L. Qiu, C.-P. Chu, T. Shirasaka, H. Tsukino, H. Nakao, K. Kato, T. Kunitake, T. Katoh, and H. Kannan
Corticotrophin-Releasing Factor Augments the IH in Rat Hypothalamic Paraventricular Nucleus Parvocellular Neurons In Vitro
J Neurophysiol, July 1, 2005; 94(1): 226 - 234.
[Abstract] [Full Text] [PDF]
S. C. Gammie
Current Models and Future Directions for Understanding the Neural Circuitries of Maternal Behaviors in Rodents
Behav Cogn Neurosci Rev, June 1, 2005; 4(2): 119 - 135.
[Abstract] [PDF]
D. Refojo, C. Echenique, M. B. Muller, J. M. H. M. Reul, J. M. Deussing, W. Wurst, I. Sillaber, M. Paez-Pereda, F. Holsboer, and E. Arzt
Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas
PNAS, April 26, 2005; 102(17): 6183 - 6188.
[Abstract] [Full Text] [PDF]
S. Lee and C. Rivier
Role Played by Hypothalamic Nuclear Factor-{kappa}B in Alcohol-Mediated Activation of the Rat Hypothalamic-Pituitary-Adrenal Axis
Endocrinology, April 1, 2005; 146(4): 2006 - 2014.
[Abstract] [Full Text] [PDF]
O. Stiedl, M. Meyer, O. Jahn, S. O. Ogren, and J. Spiess
Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear
J. Pharmacol. Exp. Ther., March 1, 2005; 312(3): 905 - 916.
[Abstract] [Full Text] [PDF]
Y. Nakade, D. Tsuchida, H. Fukuda, M. Iwa, T. N. Pappas, and T. Takahashi
Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R427 - R432.
[Abstract] [Full Text] [PDF]
D. Daniels, S. Markison, H. J. Grill, and J. M. Kaplan
Central Structures Necessary and Sufficient for Ingestive and Glycemic Responses to Urocortin I Administration
J. Neurosci., December 15, 2004; 24(50): 11457 - 11462.
[Abstract] [Full Text] [PDF]
G. N. Wade and J. E. Jones
Neuroendocrinology of nutritional infertility
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1277 - R1296.
[Abstract] [Full Text] [PDF]
R. S. Weisinger, J. R. Blair-West, P. Burns, D. A. Denton, B. Purcell, W. Vale, J. Rivier, H. S. Weisinger, and C. N. May
Cardiovascular Effects of Long-Term Central and Peripheral Administration of Urocortin, Corticotropin-Releasing Factor, and Adrenocorticotropin in Sheep
Endocrinology, December 1, 2004; 145(12): 5598 - 5604.
[Abstract] [Full Text] [PDF]
T. Matys, R. Pawlak, E. Matys, C. Pavlides, B. S. McEwen, and S. Strickland
Tissue plasminogen activator promotes the effects of corticotropin-releasing factor on the amygdala and anxiety-like behavior
PNAS, November 16, 2004; 101(46): 16345 - 16350.
[Abstract] [Full Text] [PDF]
H. P. Jedema and A. A. Grace
Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus Recorded In Vitro
J. Neurosci., October 27, 2004; 24(43): 9703 - 9713.
[Abstract] [Full Text] [PDF]
C. Porcher, V. Sinniger, A. Juhem, P. Mouchet, and B. Bonaz
Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis
Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G803 - G814.
[Abstract] [Full Text] [PDF]
K. P. Kinzig, D. A. D'Alessio, J. P. Herman, R. R. Sakai, T. P. Vahl, H. F. Figueiredo, E. K. Murphy, and R. J. Seeley
CNS Glucagon-Like Peptide-1 Receptors Mediate Endocrine and Anxiety Responses to Interoceptive and Psychogenic Stressors
J. Neurosci., July 16, 2003; 23(15): 6163 - 6170.
[Abstract] [Full Text] [PDF]
C. L. Rivier, D. E. Grigoriadis, and J. E. Rivier
Role of Corticotropin-Releasing Factor Receptors Type 1 and 2 in Modulating the Rat Adrenocorticotropin Response to Stressors
Endocrinology, June 1, 2003; 144(6): 2396 - 2403.
[Abstract] [Full Text] [PDF]
K. Inoue, G. R. Valdez, T. M. Reyes, L. E. Reinhardt, A. Tabarin, J. Rivier, W. W. Vale, P. E. Sawchenko, G. F. Koob, and E. P. Zorrilla
Human Urocortin II, a Selective Agonist for the Type 2 Corticotropin-Releasing Factor Receptor, Decreases Feeding and Drinking in the Rat
J. Pharmacol. Exp. Ther., April 1, 2003; 305(1): 385 - 393.
[Abstract] [Full Text]
K. P. Kinzig, D. A. D'Alessio, and R. J. Seeley
The Diverse Roles of Specific GLP-1 Receptors in the Control of Food Intake and the Response to Visceral Illness
J. Neurosci., December 1, 2002; 22(23): 10470 - 10476.
[Abstract] [Full Text] [PDF]
B. Roozendaal, K. L. Brunson, B. L. Holloway, J. L. McGaugh, and T. Z. Baram
Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
PNAS, October 15, 2002; 99(21): 13908 - 13913.
[Abstract] [Full Text] [PDF]
A. D. Le, S. Harding, W. Juzytsch, P. J. Fletcher, and Y. Shaham
The Role of Corticotropin-Releasing Factor in the Median Raphe Nucleus in Relapse to Alcohol
J. Neurosci., September 15, 2002; 22(18): 7844 - 7849.
[Abstract] [Full Text] [PDF]
J. C. Schiltz and P. E. Sawchenko
Distinct Brain Vascular Cell Types Manifest Inducible Cyclooxygenase Expression as a Function of the Strength and Nature of Immune Insults
J. Neurosci., July 1, 2002; 22(13): 5606 - 5618.
[Abstract] [Full Text] [PDF]
H. J. Grill, M. W. Schwartz, J. M. Kaplan, J. S. Foxhall, J. Breininger, and D. G. Baskin
Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake
Endocrinology, January 1, 2002; 143(1): 239 - 246.
[Abstract] [Full Text] [PDF]
Z. Sarnyai, Y. Shaham, and S. C. Heinrichs
The Role of Corticotropin-Releasing Factor in Drug Addiction
Pharmacol. Rev., June 1, 2001; 53(2): 209 - 244.
[Abstract] [Full Text] [PDF]
N. Kihara, M. Fujimura, I. Yamamoto, E. Itoh, A. Inui, and M. Fujimiya
Effects of central and peripheral urocortin on fed and fasted gastroduodenal motor activity in conscious rats
Am J Physiol Gastrointest Liver Physiol, March 1, 2001; 280(3): G406 - G419.
[Abstract] [Full Text] [PDF]
T. M. Reyes, K. Lewis, M. H. Perrin, K. S. Kunitake, J. Vaughan, C. A. Arias, J. B. Hogenesch, J. Gulyas, J. Rivier, W. W. Vale, et al.
Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
PNAS, February 27, 2001; 98(5): 2843 - 2848.
[Abstract] [Full Text] [PDF]
C. A. Lowry, J. E. Rodda, S. L. Lightman, and C. D. Ingram
Corticotropin-Releasing Factor Increases In Vitro Firing Rates of Serotonergic Neurons in the Rat Dorsal Raphe Nucleus: Evidence for Activation of a Topographically Organized Mesolimbocortical Serotonergic System
J. Neurosci., October 15, 2000; 20(20): 7728 - 7736.
[Abstract] [Full Text] [PDF]
M. J. Bradbury, M. I. McBurnie, D. A. Denton, K.-F. Lee, and W. W. Vale
Modulation of Urocortin-Induced Hypophagia and Weight Loss by Corticotropin-Releasing Factor Receptor 1 Deficiency in Mice
Endocrinology, August 1, 2000; 141(8): 2715 - 2724.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|