 |
 Previous Article | Next Article 
The Journal of Neuroscience, February 1, 2000, 20(3):986-991
Role of Circadian Activation of Mitogen-Activated Protein Kinase
in Chick Pineal Clock Oscillation
Kamon
Sanada,
Yuichiro
Hayashi,
Yuko
Harada,
Toshiyuki
Okano, and
Yoshitaka
Fukada
Department of Biophysics and Biochemistry, Graduate School of
Science, The University of Tokyo and CREST, Japan Science and
Technology Corporation, Tokyo 113-0033, Japan
A circadian pacemaker generates a rhythm with a period of ~24 hr
even in the absence of environmental time cues. Several photosensitive neuronal tissues such as the retina and pineal gland contain the autonomous circadian pacemaker together with the photic-input pathway
responsible for entrainment of the pacemaker to the daily light/dark
cycle. We show here that, in constant darkness, chick pineal
mitogen-activated protein kinase (MAPK) exhibited an in vivo circadian rhythm in tyrosine phosphorylation and in
enzymatic activity with a peak during subjective night. Phosphorylated
and hence activated MAPK was rapidly dephosphorylated after light illumination during the nighttime when light induces a phase-shift of
the pacemaker. The circadian rhythmicity in MAPK phosphorylation was
also observed in the cultured pineal gland, and importantly, MAPK
kinase inhibitor treatment during subjective night not only shifted the
time-of-peak of MAPK phosphorylation but also induced a remarkable
phase-delay of the circadian pacemaker. These results indicate an
important role of MAPK for time keeping in circadian clock systems.
Key words:
circadian rhythm; pineal gland; tyrosine phosphorylation; mitogen-activated protein kinase; chick
Copyright © 2000 Society for Neuroscience 0270-6474/00/203986-06$05.00/0
This article has been cited by other articles:
|
|
|
|
 
K. Thelen, T. Georg, S. Bertuch, P. Zelina, and G. E. Pollerberg
Ubiquitination and Endocytosis of Cell Adhesion Molecule DM-GRASP Regulate Its Cell Surface Presence and Affect Its Role for Axon Navigation
J. Biol. Chem.,
November 21, 2008;
283(47):
32792 - 32801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Akashi, N. Hayasaka, S. Yamazaki, and K. Node
Mitogen-Activated Protein Kinase Is a Functional Component of the Autonomous Circadian System in the Suprachiasmatic Nucleus
J. Neurosci.,
April 30, 2008;
28(18):
4619 - 4623.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. W. Vitalini, R. M. de Paula, C. S. Goldsmith, C. A. Jones, K. A. Borkovich, and D. Bell-Pedersen
Circadian rhythmicity mediated by temporal regulation of the activity of p38 MAPK
PNAS,
November 13, 2007;
104(46):
18223 - 18228.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. J. Belden, L. F. Larrondo, A. C. Froehlich, M. Shi, C.-H. Chen, J. J. Loros, and J. C. Dunlap
The band mutation in Neurospora crassa is a dominant allele of ras-1 implicating RAS signaling in circadian output
Genes & Dev.,
June 15, 2007;
21(12):
1494 - 1505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Harada, M. Sakai, N. Kurabayashi, T. Hirota, and Y. Fukada
Ser-557-phosphorylated mCRY2 Is Degraded upon Synergistic Phosphorylation by Glycogen Synthase Kinase-3{beta}
J. Biol. Chem.,
September 9, 2005;
280(36):
31714 - 31721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sanada, Y. Harada, M. Sakai, T. Todo, and Y. Fukada
Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinase
Genes Cells,
August 1, 2004;
9(8):
697 - 708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hasegawa and G. M. Cahill
Regulation of the Circadian Oscillator in Xenopus Retinal Photoreceptors by Protein Kinases Sensitive to the Stress-activated Protein Kinase Inhibitor, SB 203580
J. Biol. Chem.,
May 21, 2004;
279(21):
22738 - 22746.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Q. Butcher, B. Lee, and K. Obrietan
Temporal Regulation of Light-Induced Extracellular Signal-Regulated Kinase Activation in the Suprachiasmatic Nucleus
J Neurophysiol,
December 1, 2003;
90(6):
3854 - 3863.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Yadav, M. Straume, J. Heath III, and M. Zatz
Are Changes in MAPK/ERK Necessary or Sufficient for Entrainment in Chick Pineal Cells?
J. Neurosci.,
November 5, 2003;
23(31):
10021 - 10031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Ho, M. Mackova, C. Cho, and C. L. Chik
Regulation of 90-Kilodalton Ribosomal S6 Kinase Phosphorylation in the Rat Pineal Gland
Endocrinology,
August 1, 2003;
144(8):
3344 - 3350.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hayashi, K. Sanada, T. Hirota, F. Shimizu, and Y. Fukada
p38 Mitogen-activated Protein Kinase Regulates Oscillation of Chick Pineal Circadian Clock
J. Biol. Chem.,
June 27, 2003;
278(27):
25166 - 25171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Shimizu, M. Okada, K. Nagai, and Y. Fukada
Suprachiasmatic Nucleus Circadian Oscillatory Protein, a Novel Binding Partner of K-Ras in the Membrane Rafts, Negatively Regulates MAPK Pathway
J. Biol. Chem.,
April 18, 2003;
278(17):
14920 - 14925.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. N. Coogan and H. D. Piggins
Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster
J. Neurosci.,
April 1, 2003;
23(7):
3085 - 3093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Yoshimura, Y. Yokota, A. Ishikawa, S. Yasuo, N. Hayashi, T. Suzuki, N. Okabayashi, T. Namikawa, and S. Ebihara
Mapping Quantitative Trait Loci Affecting Circadian Photosensitivity in Retinally Degenerate Mice
J Biol Rhythms,
December 1, 2002;
17(6):
512 - 519.
[Abstract]
[PDF]
|
|
|
|
|
|
|
X. Liu and C. B. Green
Circadian Regulation of nocturnin Transcription by Phosphorylated CREB in Xenopus Retinal Photoreceptor Cells
Mol. Cell. Biol.,
November 1, 2002;
22(21):
7501 - 7511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Arima, S. B. House, H. Gainer, and G. Aguilera
Neuronal Activity Is Required for the Circadian Rhythm of Vasopressin Gene Transcription in the Suprachiasmatic Nucleus in Vitro
Endocrinology,
November 1, 2002;
143(11):
4165 - 4171.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Dziema and K. Obrietan
PACAP Potentiates L-Type Calcium Channel Conductance in Suprachiasmatic Nucleus Neurons by Activating the MAPK Pathway
J Neurophysiol,
September 1, 2002;
88(3):
1374 - 1386.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Kasahara, T. Okano, T. Haga, and Y. Fukada
Opsin-G11-Mediated Signaling Pathway for Photic Entrainment of the Chicken Pineal Circadian Clock
J. Neurosci.,
September 1, 2002;
22(17):
7321 - 7325.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Q. Butcher, H. Dziema, M. Collamore, P. W. Burgoon, and K. Obrietan
The p42/44 Mitogen-activated Protein Kinase Pathway Couples Photic Input to Circadian Clock Entrainment
J. Biol. Chem.,
August 9, 2002;
277(33):
29519 - 29525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Williams, H. S. Su, A. Bernards, J. Field, and A. Sehgal
A Circadian Output in Drosophila Mediated by Neurofibromatosis-1 and Ras/MAPK
Science,
September 21, 2001;
293(5538):
2251 - 2256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Ho and C. L. Chik
Adrenergic Regulation of Mitogen-Activated Protein Kinase in Rat Pinealocytes: Opposing Effects of Protein Kinase A and Protein Kinase G
Endocrinology,
December 1, 2000;
141(12):
4496 - 4502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mackova, J. R. Man, C. L. Chik, and A. K. Ho
p38MAPK Inhibition Enhances Basal and Norepinephrine-Stimulated p42/44MAPK Phosphorylation in Rat Pinealocytes
Endocrinology,
November 1, 2000;
141(11):
4202 - 4208.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Lhuillier and S. E. Dryer
Developmental Regulation of Neuronal KCa Channels by TGFbeta 1: Transcriptional and Posttranscriptional Effects Mediated by Erk MAP Kinase
J. Neurosci.,
August 1, 2000;
20(15):
5616 - 5622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Harada, K. Sanada, and Y. Fukada
Circadian Activation of Bullfrog Retinal Mitogen-activated Protein Kinase Associates with Oscillator Function
J. Biol. Chem.,
November 17, 2000;
275(47):
37078 - 37085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Sanada, T. Okano, and Y. Fukada
Mitogen-activated Protein Kinase Phosphorylates and Negatively Regulates Basic Helix-Loop-Helix-PAS Transcription Factor BMAL1
J. Biol. Chem.,
January 4, 2002;
277(1):
267 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
