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Previous Article | Next Article
The Journal of Neuroscience, February 15, 2000, 20(4):1281-1289
Comparison of Cysteine String Protein (Csp) and Mutant
-SNAP Overexpression Reveals a Role for Csp in Late Steps of Membrane Fusion in Dense-Core Granule Exocytosis in Adrenal Chromaffin Cells
Margaret E. Graham and Robert D. Burgoyne The Physiological Laboratory, The University of Liverpool, Liverpool L69 3BX, United Kingdom
Assembly of the SNARE complex and its disassembly caused by the action of soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) and NSF is crucial for the maintenance of vesicular traffic, including fusion of regulated exocytotic vesicles. Various other proteins may also have important roles in the processes leading to membrane fusion via interaction with the SNARE proteins, including the secretory vesicle cysteine string protein (Csp). Here we have examined the effect of overexpression of a dominant negative
-SNAP mutant or Csp on exocytosis of dense-core granules in single chromaffin cells monitored using amperometry to detect released catecholamine. Exocytosis of trans-Golgi network (TGN)-derived dense-core granules was substantially inhibited by expression of
Key words: exocytosis; secretion; SNAP; NSF; Csp; amperometry
Copyright © 2000 Society for Neuroscience 0270-6474/00/2041281-09$05.00/0
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