 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 2000, 20(4):1635-1642
Chemical Stimulation of the Ventral Hippocampus Elevates Nucleus Accumbens Dopamine by Activating Dopaminergic Neurons of the Ventral Tegmental Area
Mark Legault1, Pierre-Paul Rompré2, and Roy A. Wise1 1 Center for Studies in Behavioral Neurobiology, Department of Psychology, Concordia University, Montreal, H3G 1M8 Quebec, Canada, and 2 Centre de Recherche Fernand-Seguin et Departement de Psychiatrie, Université de Montréal, Montréal, H1N 3V2 Quebec, Canada
Dual-probe microdialysis (with HPLC and electrochemical detection) in freely moving rats and single-unit recording in anesthetized rats were used to study the extent to which impulse flow through the ventral tegmental area (VTA) contributes to elevations in nucleus accumbens (NAS) dopamine (DA) evoked by stimulation of the ventral subiculum (VS). During perfusion of artificial extracellular fluid into the VTA, injections of 0.74 µg of the excitatory amino acid NMDA into the VS elevated accumbens DA to >150% of basal values. During intra-VTA perfusion of either 1 µM tetrodotoxin (which blocks impulse flow) or 1 mM kynurenic acid (which blocks excitatory glutamate receptors), injections of NMDA into the VS failed to elevate accumbens DA. Thus, increased impulse flow through VTA DA neurons, mediated by excitatory glutamate inputs to this region, appears critical for VS stimulation to elevate NAS DA. Increased impulse flow through VTA DA neurons was confirmed using single-unit recording in anesthetized rats. Intra-VS NMDA injections increased the firing rates of 45% (14 of 31), decreased the firing rates of 13% (4 of 31), and had no effect on 42% (13 of 31) of VTA DA neurons. Increases in firing rates were evident within 15 min of NMDA injections, a time at which VS NMDA injections elevate accumbens DA in awake animals. The results of the present experiments identify the VTA as a critical site through which outputs from the VS modulate NAS dopaminergic neurotransmission.
Key words: ventral subiculum; microdialysis; tetrodotoxin; single unit; NMDA; ventral tegmental area; accumbens; dopamine
Copyright © 2000 Society for Neuroscience 0270-6474/00/2041635-08$05.00/0
This article has been cited by other articles:
G. J. Lyon, A. Abi-Dargham, H. Moore, J. A. Lieberman, J. A. Javitch, and D. Sulzer
Presynaptic Regulation of Dopamine Transmission in Schizophrenia
Schizophr Bull, June 12, 2009; (2009) sbp010v1.
[Abstract] [Full Text] [PDF]
Z.-B. You, B. Wang, D. Zitzman, and R. A. Wise
Acetylcholine Release in the Mesocorticolimbic Dopamine System during Cocaine Seeking: Conditioned and Unconditioned Contributions to Reward and Motivation
J. Neurosci., September 3, 2008; 28(36): 9021 - 9029.
[Abstract] [Full Text] [PDF]
Y. Zhang, M. M. Behrens, and J. E. Lisman
Prolonged Exposure to NMDAR Antagonist Suppresses Inhibitory Synaptic Transmission in Prefrontal Cortex
J Neurophysiol, August 1, 2008; 100(2): 959 - 965.
[Abstract] [Full Text] [PDF]
B. Wang, Y. Shaham, D. Zitzman, S. Azari, R. A. Wise, and Z.-B. You
Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking
J. Neurosci., June 1, 2005; 25(22): 5389 - 5396.
[Abstract] [Full Text] [PDF]
D. N. Abrous, M. Koehl, and M. Le Moal
Adult Neurogenesis: From Precursors to Network and Physiology
Physiol Rev, April 1, 2005; 85(2): 523 - 569.
[Abstract] [Full Text] [PDF]
P. R. Szeszko, E. Goldberg, H. Gunduz-Bruce, M. Ashtari, D. Robinson, A. K. Malhotra, T. Lencz, J. Bates, D. T. Crandall, J. M. Kane, et al.
Smaller Anterior Hippocampal Formation Volume in Antipsychotic-Naive Patients With First-Episode Schizophrenia
Am J Psychiatry, December 1, 2003; 160(12): 2190 - 2197.
[Abstract] [Full Text] [PDF]
W. Sun and G. V. Rebec
Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats
J. Neurosci., November 12, 2003; 23(32): 10258 - 10264.
[Abstract] [Full Text] [PDF]
D. C. Cooper, S. J. Moore, N. P. Staff, and N. Spruston
Psychostimulant-Induced Plasticity of Intrinsic Neuronal Excitability in Ventral Subiculum
J. Neurosci., October 29, 2003; 23(30): 9937 - 9946.
[Abstract] [Full Text] [PDF]
S. C. Harvey, K. L. Foster, P. F. McKay, M. R. Carroll, R. Seyoum, J. E. Woods II, C. Grey, C. M. Jones, S. McCane, R. Cummings, et al.
The GABAA Receptor alpha 1 Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors
J. Neurosci., May 1, 2002; 22(9): 3765 - 3775.
[Abstract] [Full Text] [PDF]
J. G. Howland, P. Taepavarapruk, and A. G. Phillips
Glutamate Receptor-Dependent Modulation of Dopamine Efflux in the Nucleus Accumbens by Basolateral, But Not Central, Nucleus of the Amygdala in Rats
J. Neurosci., February 1, 2002; 22(3): 1137 - 1145.
[Abstract] [Full Text] [PDF]
S. B. Floresco, C. L. Todd, and A. A. Grace
Glutamatergic Afferents from the Hippocampus to the Nucleus Accumbens Regulate Activity of Ventral Tegmental Area Dopamine Neurons
J. Neurosci., July 1, 2001; 21(13): 4915 - 4922.
[Abstract] [Full Text] [PDF]
S. R. Vorel, X. Liu, R. J. Hayes, J. A. Spector, and E. L. Gardner
Relapse to Cocaine-Seeking After Hippocampal Theta Burst Stimulation
Science, May 11, 2001; 292(5519): 1175 - 1178.
[Abstract] [Full Text]
|
|
|
|
 |
|