QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (75) Citing Articles via Google Scholar Google Scholar Articles by Werner, A. Articles by Raivich, G. Search for Related Content PubMed PubMed Citation Articles by Werner, A. Articles by Raivich, G.

 Previous Article  |  Next Article 

The Journal of Neuroscience, March 1, 2000, 20(5):1822-1830

Impaired Axonal Regeneration in 7 Integrin-Deficient Mice

Alexander Werner¹, Michael Willem², Leonard L. Jones¹, Georg W. Kreutzberg¹, Ulrike Mayer², and Gennadij Raivich¹

¹ Department of Neuromorphology, Max-Planck-Institute of Neurobiology, and ² Department of Protein Chemistry, Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany

The interplay between growing axons and the extracellular substrate is pivotal for directing axonal outgrowth during development and regeneration. Here we show an important role for the neuronal cell adhesion molecule 71 integrin during peripheral nerve regeneration. Axotomy led to a strong increase of this integrin on regenerating motor and sensory neurons, but not on the normally nonregenerating CNS neurons. 7 and 1 subunits were present on the axons and their growth cones in the regenerating facial nerve. Transgenic deletion of the 7 subunit caused a significant reduction of axonal elongation. The associated delay in the reinnervation of the whiskerpad, a peripheral target of the facial motor neurons, points to an important role for this integrin in the successful execution of axonal regeneration.

Key words: axonal regeneration; reinnervation; facial nerve; growth cone; motoneuron; integrin; knock-out mice

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/2051822-09$05.00/0

This article has been cited by other articles:

				M. R. Andrews, S. Czvitkovich, E. Dassie, C. F. Vogelaar, A. Faissner, B. Blits, F. H. Gage, C. ffrench-Constant, and J. W. Fawcett {alpha}9 Integrin Promotes Neurite Outgrowth on Tenascin-C and Enhances Sensory Axon Regeneration J. Neurosci., April 29, 2009; 29(17): 5546 - 5557. [Abstract] [Full Text] [PDF]

				D. Malin, E. Sonnenberg-Riethmacher, D. Guseva, R. Wagener, A. Aszodi, A. Irintchev, and D. Riethmacher The extracellular-matrix protein matrilin 2 participates in peripheral nerve regeneration J. Cell Sci., April 1, 2009; 122(7): 995 - 1004. [Abstract] [Full Text] [PDF]

				C. E. E. M. Van der Zee, M. Kreft, G. Beckers, A. Kuipers, and A. Sonnenberg Conditional Deletion of the Itgb4 Integrin Gene in Schwann Cells Leads to Delayed Peripheral Nerve Regeneration J. Neurosci., October 29, 2008; 28(44): 11292 - 11303. [Abstract] [Full Text] [PDF]

				D. Tonge, K. Chan, N. Zhu, A. Panjwani, M. Arno, S. Lynham, M. Ward, A. Snape, and J. Pizzey Enhancement of axonal regeneration by in vitro conditioning and its inhibition by cyclopentenone prostaglandins J. Cell Sci., August 1, 2008; 121(15): 2565 - 2577. [Abstract] [Full Text] [PDF]

				M. Makwana, L. L. Jones, D. Cuthill, H. Heuer, M. Bohatschek, M. Hristova, S. Friedrichsen, I. Ormsby, D. Bueringer, A. Koppius, et al. Endogenous Transforming Growth Factor {beta}1 Suppresses Inflammation and Promotes Survival in Adult CNS J. Neurosci., October 17, 2007; 27(42): 11201 - 11213. [Abstract] [Full Text] [PDF]

				R. Seijffers, C. D. Mills, and C. J. Woolf ATF3 Increases the Intrinsic Growth State of DRG Neurons to Enhance Peripheral Nerve Regeneration J. Neurosci., July 25, 2007; 27(30): 7911 - 7920. [Abstract] [Full Text] [PDF]

				B. Ren, Y. P. Yu, G. C. Tseng, C. Wu, K. Chen, U. N. Rao, J. Nelson, G. K. Michalopoulos, and J.-H. Luo Analysis of Integrin {alpha}7 Mutations in Prostate Cancer, Liver Cancer, Glioblastoma Multiforme, and Leiomyosarcoma J Natl Cancer Inst, June 6, 2007; 99(11): 868 - 880. [Abstract] [Full Text] [PDF]

				P. G. Leclere, E. Norman, F. Groutsi, R. Coffin, U. Mayer, J. Pizzey, and D. Tonge Impaired Axonal Regeneration by Isolectin B4-Binding Dorsal Root Ganglion Neurons In Vitro J. Neurosci., January 31, 2007; 27(5): 1190 - 1199. [Abstract] [Full Text] [PDF]

				F.-Q. Zhou and W. D Snider Intracellular control of developmental and regenerative axon growth Phil Trans R Soc B, September 29, 2006; 361(1473): 1575 - 1592. [Abstract] [Full Text] [PDF]

				F.-Q. Zhou, M. Walzer, Y.-H. Wu, J. Zhou, S. Dedhar, and W. D. Snider Neurotrophins support regenerative axon assembly over CSPGs by an ECM-integrin-independent mechanism J. Cell Sci., July 1, 2006; 119(13): 2787 - 2796. [Abstract] [Full Text] [PDF]

				L. Perez-Martinez and D. M. Jaworski Tissue Inhibitor of Metalloproteinase-2 Promotes Neuronal Differentiation by Acting as an Anti-Mitogenic Signal J. Neurosci., May 18, 2005; 25(20): 4917 - 4929. [Abstract] [Full Text] [PDF]

				W. Wallquist, S. Plantman, S. Thams, J. Thyboll, J. Kortesmaa, J. Lannergren, A. Domogatskaya, S. O. Ogren, M. Risling, H. Hammarberg, et al. Impeded Interaction between Schwann Cells and Axons in the Absence of Laminin {alpha}4 J. Neurosci., April 6, 2005; 25(14): 3692 - 3700. [Abstract] [Full Text] [PDF]

				M. L. T. Mercado, A. Nur-e-Kamal, H.-Y. Liu, S. R. Gross, R. Movahed, and S. Meiners Neurite Outgrowth by the Alternatively Spliced Region of Human Tenascin-C Is Mediated by Neuronal {alpha}7{beta}1 Integrin J. Neurosci., January 7, 2004; 24(1): 238 - 247. [Abstract] [Full Text] [PDF]

				P. W. Grabham, B. Reznik, and D. J. Goldberg Microtubule and Rac 1-dependent F-actin in growth cones J. Cell Sci., September 15, 2003; 116(18): 3739 - 3748. [Abstract] [Full Text] [PDF]

				U. Mayer Integrins: Redundant or Important Players in Skeletal Muscle? J. Biol. Chem., April 18, 2003; 278(17): 14587 - 14590. [Full Text] [PDF]

				R. S. Schmid and E.S. Anton Role of Integrins in the Development of the Cerebral Cortex Cereb Cortex, March 1, 2003; 13(3): 219 - 224. [Abstract] [Full Text] [PDF]

				B. Buttner, C. Kannicht, C. Schmidt, K. Loster, W. Reutter, H.-Y. Lee, S. Nohring, and R. Horstkorte Biochemical Engineering of Cell Surface Sialic Acids Stimulates Axonal Growth J. Neurosci., October 15, 2002; 22(20): 8869 - 8875. [Abstract] [Full Text] [PDF]

				M. G. Vogelezang, Z. Liu, J. B. Relvas, G. Raivich, S. S. Scherer, and C. ffrench-Constant {alpha}4 Integrin Is Expressed during Peripheral Nerve Regeneration and Enhances Neurite Outgrowth J. Neurosci., September 1, 2001; 21(17): 6732 - 6744. [Abstract] [Full Text] [PDF]

				D. Bouvard, C. Brakebusch, E. Gustafsson, A. Aszodi, T. Bengtsson, A. Berna, and R. Fassler Functional Consequences of Integrin Gene Mutations in Mice Circ. Res., July 30, 2001; 89(3): 211 - 223. [Abstract] [Full Text] [PDF]

				A. Horvat, F.-W. Schwaiger, G. Hager, F. Brocker, R. Streif, P. G. Knyazev, A. Ullrich, and G. W. Kreutzberg A Novel Role for Protein Tyrosine Phosphatase SHP1 in Controlling Glial Activation in the Normal and Injured Nervous System J. Neurosci., February 1, 2001; 21(3): 865 - 874. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help