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The Journal of Neuroscience, March 1, 2000, 20(5):1822-1830
Impaired Axonal Regeneration in  7 Integrin-Deficient Mice
Alexander
Werner1,
Michael
Willem2,
Leonard L.
Jones1,
Georg W.
Kreutzberg1,
Ulrike
Mayer2, and
Gennadij
Raivich1
1 Department of Neuromorphology, Max-Planck-Institute
of Neurobiology, and 2 Department of Protein Chemistry,
Max-Planck-Institute of Biochemistry, 82152 Martinsried, Germany
The interplay between growing axons and the extracellular substrate
is pivotal for directing axonal outgrowth during development and
regeneration. Here we show an important role for the neuronal cell
adhesion molecule  7 1 integrin during peripheral nerve
regeneration. Axotomy led to a strong increase of this integrin on
regenerating motor and sensory neurons, but not on the normally
nonregenerating CNS neurons. 7 and 1 subunits were present on the
axons and their growth cones in the regenerating facial nerve.
Transgenic deletion of the 7 subunit caused a significant reduction
of axonal elongation. The associated delay in the reinnervation of the
whiskerpad, a peripheral target of the facial motor neurons, points to
an important role for this integrin in the successful execution of axonal regeneration.
Key words:
axonal regeneration; reinnervation; facial nerve; growth
cone; motoneuron; integrin; knock-out mice
Copyright © 2000 Society for Neuroscience 0270-6474/00/2051822-09$05.00/0
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