 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 1, 2000, 20(5):1858-1868
Embryonic and Early Fetal Development of the Human Neocortex
Gundela Meyer1, Jean Pierre Schaaps2, Louis Moreau2, and André M. Goffinet3 1 Department of Anatomy, Faculty of Medicine, University La Laguna, 38071 La Laguna/Tenerife, Spain, 2 Department of Embryology, University of Liege Medical School, B4000 Liege, Belgium, and 3 Neurobiology Unit, University Namur Medical School, B5000 Namur, Belgium
Early corticogenesis was studied in human embryos and early fetuses from Carnegie stages 16 to 22 (5-8 gestational weeks) by using immunohistochemistry for Reelin (Reln), calretinin (CR), and glutamic acid decarboxylase (GAD). A first population of Reln-positive cells appears in the neocortical anlage at stage 16 and increases in number at stages 17-18. At stages 19-20, a monolayer of horizontal CR- and GAD-positive, Reln-negative neurons forms in the preplate, whereas Reln-positive cells shift into a subpial position. Another cell class, the pioneer projection neuron, is CR-positive but GAD- and Reln-negative; pioneer cells contribute early corticofugal axons. Pioneer cells first appear below the monolayer at stage 20 and form a pioneer plate at stage 21. The cortical plate (CP) proper emerges at stage 21 and inserts itself within the pioneer plate, which is thus split into a minor superficial component and a larger deep component that presumably corresponds to the subplate. Initial CP neurons are radially organized and mostly CR-negative. Reln-positive cells remain consistently segregated from the pioneer cells and are thus not directly involved in preplate partition. Our data indicate that the neuronal composition of the human neocortical preplate is more complex than generally described and that various neurons participate in a sequence of events that precede the emergence of the CP.
Key words: Cajal-Retzius cells; preplate; marginal zone; subplate; reelin; neuronal migration
Copyright © 2000 Society for Neuroscience 0270-6474/00/2051858-11$05.00/0
This article has been cited by other articles:
N. Bayatti, J. A. Moss, L. Sun, P. Ambrose, J. F. H. Ward, S. Lindsay, and G. J. Clowry
A Molecular Neuroanatomical Study of the Developing Human Neocortex from 8 to 17 Postconceptional Weeks Revealing the Early Differentiation of the Subplate and Subventricular Zone
Cereb Cortex, July 1, 2008; 18(7): 1536 - 1548.
[Abstract] [Full Text] [PDF]
Z. Petanjek, B. Berger, and M. Esclapez
Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
Cereb Cortex, May 13, 2008; (2008) bhn078v1.
[Abstract] [Full Text] [PDF]
N. Whittle, S. B. Sartori, M. Dierssen, G. Lubec, and N. Singewald
Fetal Down Syndrome Brains Exhibit Aberrant Levels of Neurotransmitters Critical for Normal Brain Development
Pediatrics, December 1, 2007; 120(6): e1465 - e1471.
[Abstract] [Full Text] [PDF]
I. Bystron, Z. Molnar, V. Otellin, and C. Blakemore
Tangential Networks of Precocious Neurons and Early Axonal Outgrowth in the Embryonic Human Forebrain
J. Neurosci., March 16, 2005; 25(11): 2781 - 2792.
[Abstract] [Full Text] [PDF]
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420.
[Abstract] [Full Text] [PDF]
G. Meyer, A. C. Socorro, C. G. P. Garcia, L. M. Millan, N. Walker, and D. Caput
Developmental Roles of p73 in Cajal-Retzius Cells and Cortical Patterning
J. Neurosci., November 3, 2004; 24(44): 9878 - 9887.
[Abstract] [Full Text] [PDF]
E. Auso, R. Lavado-Autric, E. Cuevas, F. E. del Rey, G. Morreale de Escobar, and P. Berbel
A Moderate and Transient Deficiency of Maternal Thyroid Function at the Beginning of Fetal Neocorticogenesis Alters Neuronal Migration
Endocrinology, September 1, 2004; 145(9): 4037 - 4047.
[Abstract] [Full Text] [PDF]
H. Abraham, C. G. Perez-Garcia, and G. Meyer
p73 and Reelin in Cajal-Retzius Cells of the Developing Human Hippocampal Formation
Cereb Cortex, May 1, 2004; 14(5): 484 - 495.
[Abstract] [Full Text] [PDF]
K. Takiguchi-Hayashi, M. Sekiguchi, S. Ashigaki, M. Takamatsu, H. Hasegawa, R. Suzuki-Migishima, M. Yokoyama, S. Nakanishi, and Y. Tanabe
Generation of Reelin-Positive Marginal Zone Cells from the Caudomedial Wall of Telencephalic Vesicles
J. Neurosci., March 3, 2004; 24(9): 2286 - 2295.
[Abstract] [Full Text] [PDF]
S. Rakic and N. Zecevic
Emerging Complexity of Layer I in Human Cerebral Cortex
Cereb Cortex, October 1, 2003; 13(10): 1072 - 1083.
[Abstract] [Full Text] [PDF]
A. Stoykova, O. Hatano, P. Gruss, and M. Gotz
Increase in Reelin-positive Cells in the Marginal Zone of Pax6 Mutant Mouse Cortex
Cereb Cortex, June 1, 2003; 13(6): 560 - 571.
[Abstract] [Full Text] [PDF]
G. Meyer, C. G. Perez-Garcia, and J. G. Gleeson
Selective Expression of Doublecortin and LIS1 in Developing Human Cortex Suggests Unique Modes of Neuronal Movement
Cereb Cortex, December 1, 2002; 12(12): 1225 - 1236.
[Abstract] [Full Text] [PDF]
Y. Xie, E. Skinner, C. Landry, V. Handley, V. Schonmann, E. Jacobs, R. Fisher, and A. Campagnoni
Influence of the Embryonic Preplate on the Organization of the Cerebral Cortex: A Targeted Ablation Model
J. Neurosci., October 15, 2002; 22(20): 8981 - 8991.
[Abstract] [Full Text] [PDF]
G. Radnikow, D. Feldmeyer, and J. Lubke
Axonal Projection, Input and Output Synapses, and Synaptic Physiology of Cajal-Retzius Cells in the Developing Rat Neocortex
J. Neurosci., August 15, 2002; 22(16): 6908 - 6919.
[Abstract] [Full Text] [PDF]
G. Meyer, C. G. Perez-Garcia, H. Abraham, and D. Caput
Expression of p73 and Reelin in the Developing Human Cortex
J. Neurosci., June 15, 2002; 22(12): 4973 - 4986.
[Abstract] [Full Text] [PDF]
I. Kostovic, M. Judas, M. Rados, and P. Hrabac
Laminar Organization of the Human Fetal Cerebrum Revealed by Histochemical Markers and Magnetic Resonance Imaging
Cereb Cortex, May 1, 2002; 12(5): 536 - 544.
[Abstract] [Full Text] [PDF]
I. H.M. Smart, C. Dehay, P. Giroud, M. Berland, and H. Kennedy
Unique Morphological Features of the Proliferative Zones and Postmitotic Compartments of the Neural Epithelium Giving Rise to Striate and Extrastriate Cortex in the Monkey
Cereb Cortex, January 1, 2002; 12(1): 37 - 53.
[Abstract] [Full Text] [PDF]
T. Voigt, T. Opitz, and A. D. de Lima
Synchronous Oscillatory Activity in Immature Cortical Network Is Driven by GABAergic Preplate Neurons
J. Neurosci., November 15, 2001; 21(22): 8895 - 8905.
[Abstract] [Full Text] [PDF]
M. Thom, S. Sisodiya, W. Harkness, and F. Scaravilli
Microdysgenesis in temporal lobe epilepsy: A quantitative and immunohistochemical study of white matter neurones
Brain, November 1, 2001; 124(11): 2299 - 2309.
[Abstract] [Full Text] [PDF]
N. Zecevic and P. Rakic
Development of Layer I Neurons in the Primate Cerebral Cortex
J. Neurosci., August 1, 2001; 21(15): 5607 - 5619.
[Abstract] [Full Text] [PDF]
S. H. Eriksson, M. Thom, J. Heffernan, W. R. Lin, B. N. Harding, M. V. Squier, and S. M. Sisodiya
Persistent reelin-expressing Cajal-Retzius cells in polymicrogyria
Brain, July 1, 2001; 124(7): 1350 - 1361.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|