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Previous Article | Next Article
The Journal of Neuroscience, March 15, 2000, 20(6):2175-2182
Functional GluR6 Kainate Receptors in the Striatum: Indirect Downregulation of Synaptic Transmission
Karima Chergui, Alexandre Bouron, Elisabeth Normand, and Christophe Mulle Centre National de la Recherche Scientifique, Unite Mixte Recherche 5091, Université Victor Segalen-Bordeaux II, 33076 Bordeaux Cedex, France
Kainate receptors (KARs) are abundantly expressed in the basal ganglia, but their function in synaptic transmission has not been established. In the present study, we show that the GluR6 subunit of KARs is expressed in both substance P- and enkephalin-containing GABAergic projection neurons of the mouse striatum. Using whole-cell voltage-clamp recordings in brain slices, we demonstrate the presence of functional KARs in the dorsal striatum activated by low concentrations of the AMPA/KAR agonist domoate in wild-type but not GluR6-deficient mice. Despite the abundance of KARs, we found no evidence for synaptic activation of these receptors after single or repetitive stimulation of glutamatergic afferents. Domoate induces a transient increase in the frequency of spontaneous IPSCs of small amplitude and a sustained depression of large IPSCs evoked by minimal electrical stimulation within the striatum in wild-type mice but not in GluR6-deficient mice. This depressant effect is inhibited in presence of adenosine A2A receptor antagonists, ZM-241385 and SCH-58261. These data strongly suggest that, in striatal neurons, KARs depress GABAergic synaptic transmission indirectly via release of adenosine acting on A2A receptors.
Key words: GluR6; kainate receptors; glutamate; IPSC; adenosine A2A receptor; mouse
Copyright © 2000 Society for Neuroscience 0270-6474/00/2062175-08$05.00/0
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