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The Journal of Neuroscience, April 1, 2000, 20(7):2742-2748
Axotomized and Intact Muscle Afferents But No Skin Afferents
Develop Ongoing Discharges of Dorsal Root Ganglion Origin after
Peripheral Nerve Lesion
Martin
Michaelis,
Xianguo
Liu, and
Wilfrid
Jänig
Physiologisches Institut, Christian-Albrechts-Universität,
24098 Kiel, Germany
After peripheral nerve lesions, some axotomized afferent
neurons develop ongoing discharges that originate in the dorsal root ganglion (DRG). We investigated in vivo which functional
types of afferent neurons contributed to this ectopic activity. Six to
twelve days after the gastrocnemius soleus (GS) nerve supplying skeletal muscle and the sural (SU) nerve supplying skin had been transected (experimental group E1), 20.4% of afferent neurons with
myelinated axons projecting into the GS nerve produced ongoing discharges of irregular or bursting pattern. In contrast, all SU
neurons were silent. Additional transection of peroneal and tibial
nerves (group E2) induced ongoing activity in a similar percentage of
GS neurons (22.1%), but their mean discharge frequency was higher (6.0 vs 2.7 Hz), and more of them exhibited bursting discharges (63 vs
17%). When the GS nerve had been left intact while tibial, peroneal,
and SU nerve
had been transected (group E3), 18.8% of unlesioned GS
neurons developed ongoing discharges at a mean frequency of 6.1 Hz; most of them exhibited a bursting pattern. Without a preceding
nerve lesion, almost no GS neuron (1.1%) fired spontaneously. Most
afferent neurons with ongoing activity had an axonal conduction
velocity of 5-30 m/sec indicating that some of these neurons may have
had nociceptive function. These findings provide the first evidence
that after peripheral nerve injury both axotomized as well as intact
afferent neurons supplying skeletal muscle but not skin afferents
generate ongoing activity within the DRG, probably because of a yet
unknown signal in the DRG triggered by axotomy.
Key words:
dorsal root ganglion; ectopic firing; paresthesia; neuropathic pain; muscle pain; referred pain; rat
Copyright © 2000 Society for Neuroscience 0270-6474/00/2072742-07$05.00/0
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