 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, April 15, 2000, 20(8):2896-2903
Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus
Maria A. I. Åberg1, N. David Åberg1, Helena Hedbäcker1, Jan Oscarsson2, and Peter S. Eriksson1 1 Institute of Clinical Neuroscience, Sahlgrenska University Hospital, and 2 Department of Physiology and Pharmacology, Göteborg University, Göteborg, Sweden
In several species, including humans, the dentate granule cell layer (GCL) of the hippocampus exhibits neurogenesis throughout adult life. The ability to regulate adult neurogenesis pharmacologically may be of therapeutic value as a mechanism for replacing lost neurons. Insulin-like growth factor-I (IGF-I) is a growth-promoting peptide hormone that has been shown to have neurotrophic properties. The relationship between IGF-I and adult hippocampal neurogenesis is to date unknown. The aim of this study was to investigate the effect of the peripheral administration of IGF-I on cellular proliferation in the dentate subgranular proliferative zone, which contains neuronal progenitor cells, and on the subsequent migration and differentiation of progenitor cells within the GCL. Using bromodeoxyuridine (BrdU) labeling, we found a significant increase of BrdU-immunoreactive progenitors in the GCL after 6 d of peripheral IGF-I administration. To determine the cell fate in progenitor progeny, we characterized the colocalization of BrdU-immunolabeled cells with cell-specific markers. In animals treated with IGF-I for 20 d, BrdU-positive cells increased significantly. Furthermore, the fraction of newly generated neurons in the GCL increased, as evaluated by the neuronal markers Calbindin D28K, microtubule-associated protein-2, and NeuN. There was no difference in the fraction of newly generated astrocytes. Thus, our results show that peripheral infusion of IGF-I increases progenitor cell proliferation and selectively induces neurogenesis in the progeny of adult neural progenitor cells. This corresponds to a 78 ± 17% (p < 0.001) increase in the number of new neurons in IGF-I-treated animals compared with controls.
Key words: brain; rat; IGF-I; insulin-like growth factor-I; stem cell; progenitor cell; hippocampus; neurogenesis; stereology
Copyright © 2000 Society for Neuroscience 0270-6474/00/2082896-08$05.00/0
This article has been cited by other articles:
A.-L. Svensson, N. Bucht, M. Hallberg, and F. Nyberg
From the Cover: Reversal of opiate-induced apoptosis by human recombinant growth hormone in murine foetus primary hippocampal neuronal cell cultures
PNAS, May 20, 2008; 105(20): 7304 - 7308.
[Abstract] [Full Text] [PDF]
S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
J. Neurosci., November 7, 2007; 27(45): 12156 - 12167.
[Abstract] [Full Text] [PDF]
T.-Y. Eom, K. A. Roth, and R. S. Jope
Neural Precursor Cells Are Protected from Apoptosis Induced by Trophic Factor Withdrawal or Genotoxic Stress by Inhibitors of Glycogen Synthase Kinase 3
J. Biol. Chem., August 3, 2007; 282(31): 22856 - 22864.
[Abstract] [Full Text] [PDF]
N. D. Aberg, U. E. Johansson, M. A. I. Aberg, N. A. K. Hellstrom, J. Lind, C. Bull, J. Isgaard, M. F. Anderson, J. Oscarsson, and P. S. Eriksson
Peripheral Infusion of Insulin-Like Growth Factor-I Increases the Number of Newborn Oligodendrocytes in the Cerebral Cortex of Adult Hypophysectomized Rats
Endocrinology, August 1, 2007; 148(8): 3765 - 3772.
[Abstract] [Full Text] [PDF]
B. S. McEwen
Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain
Physiol Rev, July 1, 2007; 87(3): 873 - 904.
[Abstract] [Full Text] [PDF]
K. Hisaoka, M. Takebayashi, M. Tsuchioka, N. Maeda, Y. Nakata, and S. Yamawaki
Antidepressants Increase Glial Cell Line-Derived Neurotrophic Factor Production through Monoamine-Independent Activation of Protein Tyrosine Kinase and Extracellular Signal-Regulated Kinase in Glial Cells
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 148 - 157.
[Abstract] [Full Text] [PDF]
L. Y. Sun and A. Bartke
Adult Neurogenesis in the Hippocampus of Long-Lived Mice During Aging
J. Gerontol. A Biol. Sci. Med. Sci., February 1, 2007; 62(2): 117 - 125.
[Abstract] [Full Text] [PDF]
K. Chaichana, G. Zamora-Berridi, J. Camara-Quintana, and A. Quinones-Hinojosa
Neurosphere Assays: Growth Factors and Hormone Differences in Tumor and Nontumor Studies
Stem Cells, December 1, 2006; 24(12): 2851 - 2857.
[Abstract] [Full Text] [PDF]
L. Y. Sun and A. J. D'Ercole
Insulin-Like Growth Factor-I Stimulates Histone H3 and H4 Acetylation in the Brain in Vivo
Endocrinology, November 1, 2006; 147(11): 5480 - 5490.
[Abstract] [Full Text] [PDF]
Y. Ziv, H. Avidan, S. Pluchino, G. Martino, and M. Schwartz
Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury
PNAS, August 29, 2006; 103(35): 13174 - 13179.
[Abstract] [Full Text] [PDF]
O. Butovsky, M. Koronyo-Hamaoui, G. Kunis, E. Ophir, G. Landa, H. Cohen, and M. Schwartz
From the Cover: Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
PNAS, August 1, 2006; 103(31): 11784 - 11789.
[Abstract] [Full Text] [PDF]
J Svensson, M Diez, J Engel, C Wass, A Tivesten, J-O Jansson, O Isaksson, T Archer, T Hokfelt, and C Ohlsson
Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.
J. Endocrinol., June 1, 2006; 189(3): 617 - 627.
[Abstract] [Full Text] [PDF]
M. Sundberg, S. Savola, A. Hienola, L. Korhonen, and D. Lindholm
Glucocorticoid hormones decrease proliferation of embryonic neural stem cells through ubiquitin-mediated degradation of cyclin D1.
J. Neurosci., May 17, 2006; 26(20): 5402 - 5410.
[Abstract] [Full Text] [PDF]
C. P. Donahue, K. S. Kosik, and T. J. Shors
Growth hormone is produced within the hippocampus where it responds to age, sex, and stress
PNAS, April 11, 2006; 103(15): 6031 - 6036.
[Abstract] [Full Text] [PDF]
N. N. Johnson-Farley, T. Travkina, and D. S. Cowen
Cumulative Activation of Akt and Consequent Inhibition of Glycogen Synthase Kinase-3 by Brain-Derived Neurotrophic Factor and Insulin-Like Growth Factor-1 in Cultured Hippocampal Neurons
J. Pharmacol. Exp. Ther., March 1, 2006; 316(3): 1062 - 1069.
[Abstract] [Full Text] [PDF]
E. Carro, C. Spuch, J. L. Trejo, D. Antequera, and I. Torres-Aleman
Choroid Plexus Megalin Is Involved in Neuroprotection by Serum Insulin-Like Growth Factor I
J. Neurosci., November 23, 2005; 25(47): 10884 - 10893.
[Abstract] [Full Text] [PDF]
A. S. Naylor, A. I. Persson, P. S. Eriksson, I. H. Jonsdottir, and T. Thorlin
Extended Voluntary Running Inhibits Exercise-Induced Adult Hippocampal Progenitor Proliferation in the Spontaneously Hypertensive Rat
J Neurophysiol, May 1, 2005; 93(5): 2406 - 2414.
[Abstract] [Full Text] [PDF]
D. N. Abrous, M. Koehl, and M. Le Moal
Adult Neurogenesis: From Precursors to Network and Physiology
Physiol Rev, April 1, 2005; 85(2): 523 - 569.
[Abstract] [Full Text] [PDF]
R. G. Smith, L. Betancourt, and Y. Sun
Molecular Endocrinology and Physiology of the Aging Central Nervous System
Endocr. Rev., April 1, 2005; 26(2): 203 - 250.
[Abstract] [Full Text] [PDF]
L. Y. Sun, M. S. Evans, J. Hsieh, J. Panici, and A. Bartke
Increased Neurogenesis in Dentate Gyrus of Long-Lived Ames Dwarf Mice
Endocrinology, March 1, 2005; 146(3): 1138 - 1144.
[Abstract] [Full Text] [PDF]
J. Nyberg, M. F. Anderson, B. Meister, A.-M. Alborn, A.-K. Strom, A. Brederlau, A.-C. Illerskog, O. Nilsson, T. J. Kieffer, M. A. Hietala, et al.
Glucose-Dependent Insulinotropic Polypeptide Is Expressed in Adult Hippocampus and Induces Progenitor Cell Proliferation
J. Neurosci., February 16, 2005; 25(7): 1816 - 1825.
[Abstract] [Full Text] [PDF]
W. Sun, A. Winseck, S. Vinsant, O.-h. Park, H. Kim, and R. W. Oppenheim
Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax
J. Neurosci., December 8, 2004; 24(49): 11205 - 11213.
[Abstract] [Full Text] [PDF]
R. D. Hodge, A. J. D'Ercole, and J. R. O'Kusky
Insulin-Like Growth Factor-I Accelerates the Cell Cycle by Decreasing G1 Phase Length and Increases Cell Cycle Reentry in the Embryonic Cerebral Cortex
J. Neurosci., November 10, 2004; 24(45): 10201 - 10210.
[Abstract] [Full Text] [PDF]
A. Consiglio, A. Gritti, D. Dolcetta, A. Follenzi, C. Bordignon, F. H. Gage, A. L. Vescovi, and L. Naldini
From the Cover: Robust in vivo gene transfer into adult mammalian neural stem cells by lentiviral vectors
PNAS, October 12, 2004; 101(41): 14835 - 14840.
[Abstract] [Full Text] [PDF]
T. Acker and H. Acker
Cellular oxygen sensing need in CNS function: physiological and pathological implications
J. Exp. Biol., August 15, 2004; 207(18): 3171 - 3188.
[Abstract] [Full Text] [PDF]
M. Digicaylioglu, G. Garden, S. Timberlake, L. Fletcher, and S. A. Lipton
Acute neuroprotective synergy of erythropoietin and insulin-like growth factor I
PNAS, June 29, 2004; 101(26): 9855 - 9860.
[Abstract] [Full Text] [PDF]
J. Hsieh, J. B. Aimone, B. K. Kaspar, T. Kuwabara, K. Nakashima, and F. H. Gage
IGF-I instructs multipotent adult neural progenitor cells to become oligodendrocytes
J. Cell Biol., January 5, 2004; 164(1): 111 - 122.
[Abstract] [Full Text] [PDF]
R. Faigle, A. Brederlau, M. Elmi, Y. Arvidsson, T. S. Hamazaki, H. Uramoto, and K. Funa
ASK1 Inhibits Astroglial Development via p38 Mitogen-Activated Protein Kinase and Promotes Neuronal Differentiation in Adult Hippocampus-Derived Progenitor Cells
Mol. Cell. Biol., January 1, 2004; 24(1): 280 - 293.
[Abstract] [Full Text] [PDF]
R. M. Thomas and D. A. Peterson
A Neurogenic Theory of Depression Gains Momentum
Mol. Interv., December 1, 2003; 3(8): 441 - 444.
[Abstract] [Full Text] [PDF]
Y. Li, S. Eitan, J. Wu, C. J. Evans, B. Kieffer, X. Sun, and R. D. Polakiewicz
Morphine Induces Desensitization of Insulin Receptor Signaling
Mol. Cell. Biol., September 1, 2003; 23(17): 6255 - 6266.
[Abstract] [Full Text] [PDF]
M. Schubert, D. P. Brazil, D. J. Burks, J. A. Kushner, J. Ye, C. L. Flint, J. Farhang-Fallah, P. Dikkes, X. M. Warot, C. Rio, et al.
Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation
J. Neurosci., August 6, 2003; 23(18): 7084 - 7092.
[Abstract] [Full Text] [PDF]
M. A. Packer, Y. Stasiv, A. Benraiss, E. Chmielnicki, A. Grinberg, H. Westphal, S. A. Goldman, and G. Enikolopov
Nitric oxide negatively regulates mammalian adult neurogenesis
PNAS, August 5, 2003; 100(16): 9566 - 9571.
[Abstract] [Full Text] [PDF]
J. M. Parent
Injury-Induced Neurogenesis in the Adult Mammalian Brain
Neuroscientist, August 1, 2003; 9(4): 261 - 272.
[Abstract] [PDF]
J.A. Lemon, D.R. Boreham, and C.D. Rollo
A Dietary Supplement Abolishes Age-Related Cognitive Decline in Transgenic Mice Expressing Elevated Free Radical Processes
Experimental Biology and Medicine, July 1, 2003; 228(7): 800 - 810.
[Abstract] [Full Text] [PDF]
A. Nunez, E. Carro, and I. Torres-Aleman
Insulin-Like Growth Factor I Modifies Electrophysiological Properties of Rat Brain Stem Neurons
J Neurophysiol, June 1, 2003; 89(6): 3008 - 3017.
[Abstract] [Full Text] [PDF]
C. Vicario-Abejon, M. J. Yusta-Boyo, C. Fernandez-Moreno, and F. de Pablo
Locally Born Olfactory Bulb Stem Cells Proliferate in Response to Insulin-Related Factors and Require Endogenous Insulin-Like Growth Factor-I for Differentiation into Neurons and Glia
J. Neurosci., February 1, 2003; 23(3): 895 - 906.
[Abstract] [Full Text] [PDF]
S. Rivest
Editorial: Does Circulating Leptin Have the Ability to Cross the Blood-Brain Barrier and Target Neurons Directly?
Endocrinology, September 1, 2002; 143(9): 3211 - 3213.
[Full Text] [PDF]
F. W. Booth, M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg
Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy
J Appl Physiol, July 1, 2002; 93(1): 3 - 30.
[Abstract] [Full Text] [PDF]
S. Nakagawa, J.-E. Kim, R. Lee, J. E. Malberg, J. Chen, C. Steffen, Y.-J. Zhang, E. J. Nestler, and R. S. Duman
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
J. Neurosci., May 1, 2002; 22(9): 3673 - 3682.
[Abstract] [Full Text] [PDF]
R. S. Duman, J. Malberg, and S. Nakagawa
Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress
J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 401 - 407.
[Abstract] [Full Text] [PDF]
C. BROADHURST and K. WILSON
Immunology of delirium: new opportunities for treatment and research
The British Journal of Psychiatry, October 1, 2001; 179(4): 288 - 289.
[Full Text] [PDF]
B. Czeh, T. Michaelis, T. Watanabe, J. Frahm, G. de Biurrun, M. van Kampen, A. Bartolomucci, and E. Fuchs
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
PNAS, September 26, 2001; (2001) 211427898.
[Abstract] [Full Text] [PDF]
Y. Arsenijevic, S. Weiss, B. Schneider, and P. Aebischer
Insulin-Like Growth Factor-I Is Necessary for Neural Stem Cell Proliferation and Demonstrates Distinct Actions of Epidermal Growth Factor and Fibroblast Growth Factor-2
J. Neurosci., September 15, 2001; 21(18): 7194 - 7202.
[Abstract] [Full Text] [PDF]
W. Jiang, W. Gu, T. Brannstrom, R. Rosqvist, and P. Wester
Cortical Neurogenesis in Adult Rats After Transient Middle Cerebral Artery Occlusion
Stroke, May 1, 2001; 32(5): 1201 - 1207.
[Abstract] [Full Text] [PDF]
T. Niikura, Y. Hashimoto, T. Okamoto, Y. Abe, T. Yasukawa, M. Kawasumi, T. Hiraki, Y. Kita, K. Terashita, K. Kouyama, et al.
Insulin-Like Growth Factor I (IGF-I) Protects Cells from Apoptosis by Alzheimer's V642I Mutant Amyloid Precursor Protein through IGF-I Receptor in an IGF-Binding Protein-Sensitive Manner
J. Neurosci., March 15, 2001; 21(6): 1902 - 1910.
[Abstract] [Full Text] [PDF]
J. L. Trejo, E. Carro, and I. Torres-Aleman
Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
J. Neurosci., March 1, 2001; 21(5): 1628 - 1634.
[Abstract] [Full Text] [PDF]
J. E. Malberg, A. J. Eisch, E. J. Nestler, and R. S. Duman
Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
J. Neurosci., December 15, 2000; 20(24): 9104 - 9110.
[Abstract] [Full Text] [PDF]
J. R. O'Kusky, P. Ye, and A. J. D'Ercole
Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development
J. Neurosci., November 15, 2000; 20(22): 8435 - 8442.
[Abstract] [Full Text] [PDF]
N. D. Aberg, B. Carlsson, L. Rosengren, J. Oscarsson, O. G. P. Isaksson, L. Ronnback, and P. S. Eriksson
Growth Hormone Increases Connexin-43 Expression in the Cerebral Cortex and Hypothalamus
Endocrinology, October 1, 2000; 141(10): 3879 - 3886.
[Abstract] [Full Text] [PDF]
B. Czeh, T. Michaelis, T. Watanabe, J. Frahm, G. de Biurrun, M. van Kampen, A. Bartolomucci, and E. Fuchs
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
PNAS, October 23, 2001; 98(22): 12796 - 12801.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|