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Previous Article | Next Article
The Journal of Neuroscience, April 15, 2000, 20(8):2926-2933
Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain
Eva Carro1, Angel Nuñez2, Svetlana Busiguina1, and Ignacio Torres-Aleman1 1 Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain, and 2 Department of Morphology, School of Medicine, Autonoma University, 28029 Madrid, Spain
Physical exercise increases brain activity through mechanisms not yet known. We now report that in rats, running induces uptake of blood insulin-like growth factor I (IGF-I) by specific groups of neurons throughout the brain. Neurons accumulating IGF-I show increased spontaneous firing and a protracted increase in sensitivity to afferent stimulation. Furthermore, systemic injection of IGF-I mimicked the effects of exercise in the brain. Thus, brain uptake of IGF-I after either intracarotid injection or after exercise elicited the same pattern of neuronal accumulation of IGF-I, an identical widespread increase in neuronal c-Fos, and a similar stimulation of hippocampal brain-derived neurotrophic factor. When uptake of IGF-I by brain cells was blocked, the exercise-induced increase on c-Fos expression was also blocked. We conclude that serum IGF-I mediates activational effects of exercise in the brain. Thus, stimulation of the uptake of blood-borne IGF-I by nerve cells may lead to novel neuroprotective strategies.
Key words: insulin-like growth factor I; exercise actions on brain function; blood-CSF pathway; neuronal activation; c-Fos; brain-derived neurotrophic factor
Copyright © 2000 Society for Neuroscience 0270-6474/00/2082926-08$05.00/0
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