QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (171) Citing Articles via Google Scholar Google Scholar Articles by Carro, E. Articles by Torres-Aleman, I. Search for Related Content PubMed PubMed Citation Articles by Carro, E. Articles by Torres-Aleman, I. Pubmed/NCBI databases Substance via MeSH

 Previous Article  |  Next Article 

The Journal of Neuroscience, April 15, 2000, 20(8):2926-2933

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

Eva Carro¹, Angel Nuñez², Svetlana Busiguina¹, and Ignacio Torres-Aleman¹

¹ Laboratory of Neuroendocrinology, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain, and ² Department of Morphology, School of Medicine, Autonoma University, 28029 Madrid, Spain

Physical exercise increases brain activity through mechanisms not yet known. We now report that in rats, running induces uptake of blood insulin-like growth factor I (IGF-I) by specific groups of neurons throughout the brain. Neurons accumulating IGF-I show increased spontaneous firing and a protracted increase in sensitivity to afferent stimulation. Furthermore, systemic injection of IGF-I mimicked the effects of exercise in the brain. Thus, brain uptake of IGF-I after either intracarotid injection or after exercise elicited the same pattern of neuronal accumulation of IGF-I, an identical widespread increase in neuronal c-Fos, and a similar stimulation of hippocampal brain-derived neurotrophic factor. When uptake of IGF-I by brain cells was blocked, the exercise-induced increase on c-Fos expression was also blocked. We conclude that serum IGF-I mediates activational effects of exercise in the brain. Thus, stimulation of the uptake of blood-borne IGF-I by nerve cells may lead to novel neuroprotective strategies.

Key words: insulin-like growth factor I; exercise actions on brain function; blood-CSF pathway; neuronal activation; c-Fos; brain-derived neurotrophic factor

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/2082926-08$05.00/0

This article has been cited by other articles:

				A. Guzzetta, S. Baldini, A. Bancale, L. Baroncelli, F. Ciucci, P. Ghirri, E. Putignano, A. Sale, A. Viegi, N. Berardi, et al. Massage Accelerates Brain Development and the Maturation of Visual Function J. Neurosci., May 6, 2009; 29(18): 6042 - 6051. [Abstract] [Full Text] [PDF]

				I. Torres-Aleman Mouse Models of Alzheimer's Dementia: Current Concepts and New Trends Endocrinology, December 1, 2008; 149(12): 5952 - 5957. [Abstract] [Full Text] [PDF]

				L. Laviola, A. Natalicchio, S. Perrini, and F. Giorgino Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans Am J Physiol Endocrinol Metab, November 1, 2008; 295(5): E991 - E999. [Abstract] [Full Text] [PDF]

				L. Groban, H. Jobe, M. Lin, T. Houle, D. A. Kitzman, and W. Sonntag Effects of Short-Term Treadmill Exercise Training or Growth Hormone Supplementation on Diastolic Function and Exercise Tolerance in Old Rats J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 911 - 920. [Abstract] [Full Text] [PDF]

				P. N. Ainslie, J. D. Cotter, K. P. George, S. Lucas, C. Murrell, R. Shave, K. N. Thomas, M. J. A. Williams, and G. Atkinson Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing J. Physiol., August 15, 2008; 586(16): 4005 - 4010. [Abstract] [Full Text] [PDF]

				A. A. Asuni, A. Boutajangout, D. Quartermain, and E. M. Sigurdsson Immunotherapy Targeting Pathological Tau Conformers in a Tangle Mouse Model Reduces Brain Pathology with Associated Functional Improvements J. Neurosci., August 22, 2007; 27(34): 9115 - 9129. [Abstract] [Full Text] [PDF]

				B. S. McEwen Physiology and Neurobiology of Stress and Adaptation: Central Role of the Brain Physiol Rev, July 1, 2007; 87(3): 873 - 904. [Abstract] [Full Text] [PDF]

				K. Gertz, J. Priller, G. Kronenberg, K. B. Fink, B. Winter, H. Schrock, S. Ji, M. Milosevic, C. Harms, M. Bohm, et al. Physical Activity Improves Long-Term Stroke Outcome via Endothelial Nitric Oxide Synthase-Dependent Augmentation of Neovascularization and Cerebral Blood Flow Circ. Res., November 10, 2006; 99(10): 1132 - 1140. [Abstract] [Full Text] [PDF]

				U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells Phil Trans R Soc B, September 29, 2006; 361(1473): 1477 - 1497. [Abstract] [Full Text] [PDF]

				J Svensson, M Diez, J Engel, C Wass, A Tivesten, J-O Jansson, O Isaksson, T Archer, T Hokfelt, and C Ohlsson Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice. J. Endocrinol., June 1, 2006; 189(3): 617 - 627. [Abstract] [Full Text] [PDF]

				E. Carro, C. Spuch, J. L. Trejo, D. Antequera, and I. Torres-Aleman Choroid Plexus Megalin Is Involved in Neuroprotection by Serum Insulin-Like Growth Factor I J. Neurosci., November 23, 2005; 25(47): 10884 - 10893. [Abstract] [Full Text] [PDF]

				S. S. Daftary and A. C. Gore IGF-1 in the Brain as a Regulator of Reproductive Neuroendocrine Function Experimental Biology and Medicine, May 1, 2005; 230(5): 292 - 306. [Abstract] [Full Text] [PDF]

				J. Ster, C. Colomer, C. Monzo, A. Duvoid-Guillou, F. Moos, G. Alonso, and N. Hussy Insulin-Like Growth Factor-1 Inhibits Adult Supraoptic Neurons via Complementary Modulation of Mechanoreceptors and Glycine Receptors J. Neurosci., March 2, 2005; 25(9): 2267 - 2276. [Abstract] [Full Text] [PDF]

				C. Lopez-Lopez, D. LeRoith, and I. Torres-Aleman Insulin-like growth factor I is required for vessel remodeling in the adult brain PNAS, June 29, 2004; 101(26): 9833 - 9838. [Abstract] [Full Text] [PDF]

				L. Cancedda, E. Putignano, A. Sale, A. Viegi, N. Berardi, and L. Maffei Acceleration of Visual System Development by Environmental Enrichment J. Neurosci., May 19, 2004; 24(20): 4840 - 4848. [Abstract] [Full Text] [PDF]

				M. K. Dalsgaard, P. Ott, F. Dela, A. Juul, B. K. Pedersen, J. Warberg, J. Fahrenkrug, and N. H. Secher The CSF and arterial to internal jugular venous hormonal differences during exercise in humans Exp Physiol, May 1, 2004; 89(3): 271 - 277. [Abstract] [Full Text] [PDF]

				D. Ehninger and G. Kempermann Regional Effects of Wheel Running and Environmental Enrichment on Cell Genesis and Microglia Proliferation in the Adult Murine Neocortex Cereb Cortex, August 1, 2003; 13(8): 845 - 851. [Abstract] [Full Text] [PDF]

				S. K. Droste, A. Gesing, S. Ulbricht, M. B. Muller, A. C. E. Linthorst, and J. M. H. M. Reul Effects of Long-Term Voluntary Exercise on the Mouse Hypothalamic-Pituitary-Adrenocortical Axis Endocrinology, July 1, 2003; 144(7): 3012 - 3023. [Abstract] [Full Text] [PDF]

				A. Nunez, E. Carro, and I. Torres-Aleman Insulin-Like Growth Factor I Modifies Electrophysiological Properties of Rat Brain Stem Neurons J Neurophysiol, June 1, 2003; 89(6): 3008 - 3017. [Abstract] [Full Text] [PDF]

				J. C. Chavez and J. C. LaManna Activation of Hypoxia-Inducible Factor-1 in the Rat Cerebral Cortex after Transient Global Ischemia: Potential Role of Insulin-Like Growth Factor-1 J. Neurosci., October 15, 2002; 22(20): 8922 - 8931. [Abstract] [Full Text] [PDF]

				L. M. Frago, C. Paneda, S. L. Dickson, A. K. Hewson, J. Argente, and J. A. Chowen Growth Hormone (GH) and GH-Releasing Peptide-6 Increase Brain Insulin-Like Growth Factor-I Expression and Activate Intracellular Signaling Pathways Involved in Neuroprotection Endocrinology, October 1, 2002; 143(10): 4113 - 4122. [Abstract] [Full Text] [PDF]

				F. W. Booth, M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg Waging war on physical inactivity: using modern molecular ammunition against an ancient enemy J Appl Physiol, July 1, 2002; 93(1): 3 - 30. [Abstract] [Full Text] [PDF]

				R. S. Duman, J. Malberg, and S. Nakagawa Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress J. Pharmacol. Exp. Ther., November 1, 2001; 299(2): 401 - 407. [Abstract] [Full Text] [PDF]

				C. BROADHURST and K. WILSON Immunology of delirium: new opportunities for treatment and research The British Journal of Psychiatry, October 1, 2001; 179(4): 288 - 289. [Full Text] [PDF]

				E. Carro, J. L. Trejo, S. Busiguina, and I. Torres-Aleman Circulating Insulin-Like Growth Factor I Mediates the Protective Effects of Physical Exercise against Brain Insults of Different Etiology and Anatomy J. Neurosci., August 1, 2001; 21(15): 5678 - 5684. [Abstract] [Full Text] [PDF]

				J. L. Trejo, E. Carro, and I. Torres-Aleman Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus J. Neurosci., March 1, 2001; 21(5): 1628 - 1634. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help