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The Journal of Neuroscience, April 15, 2000, 20(8):2944-2953

Learning Performance of Normal and Mutant Drosophila after Repeated Conditioning Trials with Discrete Stimuli

C. D. O. Beck¹, Bradley Schroeder¹, and Ronald L. Davis^{1, 2}

Departments of ¹ Molecular and Cellular Biology and ² Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas 77030

A new olfactory conditioning procedure is described using short training trials with discrete presentation of conditioned stimuli (CS) and unconditioned stimuli (US). A short odor presentation along with a single-shock stimulus produced modest but reliable and reproducible learning. Multiple trials presented sequentially improved performance with increasing trial number. Trial spacing had a significant impact on performance. Two trials presented with a short intertrial interval (ITI) produced no improvement over a single trial; two trials with a 15 min ITI significantly boosted performance. This effect required two associative trials, because substituting one of the trials with the CS alone, US alone, or an unpaired CS-US failed to boost performance. The increase in initial performance with two trials decayed within 15 min after training. Thus, the effect is short-lived. The utility of using a battery of tests, including a single short trial, two massed trials, and two spaced trials, to investigate parameters of memory formation in several mutants was demonstrated.

Key words: Drosophila; olfactory conditioning; massed training; spaced training; learning mutant; acquisition

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Copyright © 2000 Society for Neuroscience  0270-6474/00/2082944-10$05.00/0

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