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The Journal of Neuroscience, May 1, 2000, 20(9):3319-3327

Cuneiform Neurons Activated during Cholinergically Induced Active Sleep in the Cat

Inés Pose², Sharon Sampogna¹, Michael H. Chase¹, and Francisco R. Morales^{1, 2}

¹ Department of Physiology and the Brain Research Institute, University of California at Los Angeles, Los Angeles, California 90095, and ² Departamento de Fisiología, Facultad de Medicina, Montevideo 11800, Uruguay

In the present study, we report that the cuneiform (Cun) nucleus, a brainstem structure that before now has not been implicated in sleep processes, exhibits a large number of neurons that express c-fos during carbachol-induced active sleep (AS-carbachol). Compared with control (awake) cats, during AS-carbachol, there was a 671% increase in the number of neurons that expressed c-fos in this structure. Within the Cun nucleus, three immunocytochemically distinct populations of neurons were observed. One group consisted of GABAergic neurons, which predominantly did not express c-fos during AS-carbachol. Two other different populations expressed c-fos during this state. One of the Fos-positive (Fos⁺) populations consisted of a distinct group of nitric oxide synthase (NOS)-NADPH-diaphorase (NADPH-d)-containing neurons; the neurotransmitter of the other Fos⁺ population remains unknown. The Cun nucleus did not contain cholinergic, catecholaminergic, serotonergic, or glycinergic neurons. On the basis of neuronal activation during AS-carbachol, as indicated by c-fos expression, we suggest that the Cun nucleus is involved, in an as yet unknown manner, in the physiological expression of active sleep. The finding of a population of NOS-NADPH-d containing neurons, which were activated during AS-carbachol, suggests that nitrergic modulation of their target cell groups is likely to play a role in active sleep-related physiological processes.

Key words: cuneiform nucleus; REM sleep; brainstem; immunohistochemistry; Fos; nitric oxide

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Copyright © 2000 Society for Neuroscience  0270-6474/00/2093319-09$05.00/0

This article has been cited by other articles:

				V. Abudara, A. F. Alvarez, M. H. Chase, and F. R. Morales Nitric Oxide as an Anterograde Neurotransmitter in the Trigeminal Motor Pool J Neurophysiol, July 1, 2002; 88(1): 497 - 506. [Abstract] [Full Text] [PDF]

				J. Vazquez, R. Lydic, and H. A. Baghdoyan The Nitric Oxide Synthase Inhibitor NG-Nitro-L-Arginine Increases Basal Forebrain Acetylcholine Release during Sleep and Wakefulness J. Neurosci., July 1, 2002; 22(13): 5597 - 5605. [Abstract] [Full Text] [PDF]

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