 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 2000, 20(9):3377-3386
Classical Conditioning of Feeding in Aplysia: II. Neurophysiological Correlates
Hilde A. Lechner, Douglas A. Baxter, and John H. Byrne W. M. Keck Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Anatomy, The University of Texas, Houston Medical School, Houston, Texas 77030
Feeding behavior in Aplysia californica can be classically conditioned using tactile stimulation of the lips as conditional stimulus (CS) and food as unconditional stimulus (US) [Lechner et al., 2000 (companion paper)]. Conditioning resulted in an increase in the number of CS-evoked bites that persisted for at least 24 hr after training. In this study, neurophysiological correlates of classical conditioning training were identified and characterized in an in vitro preparation of the cerebral and buccal ganglia. Stimulation of a lip nerve (AT4), which mediates mechanosensory information, resulted in a greater number of buccal motor patterns (BMPs) in ganglia isolated from animals that had received paired training than in ganglia from control animals. The majority of the evoked BMPs were classified as ingestion-like patterns. Intracellular recordings from pattern-initiating neuron B31/32 revealed that stimulation of AT4 evoked greater excitatory input in B31/32 in preparations from animals that had received paired training than from control animals. In contrast, excitatory input to buccal neuron B4/5 in response to stimulation of AT4 was not significantly increased by paired training. Moreover, correlates of classical conditioning were specific to stimulation of AT4. The number of spontaneously occurring BMPs and the intrinsic properties of two buccal neurons (B4/5 and B31/32) did not differ between groups. These results suggest that appetitive classical conditioning of feeding resulted in the pairing-specific strengthening of the polysynaptic pathway between afferent fibers and pattern-initiating neurons of the buccal central pattern generator.
Key words: neural correlates; classical conditioning; feeding behavior; Aplysia; learning and memory; buccal motor patterns
Copyright © 2000 Society for Neuroscience 0270-6474/00/2093377-10$05.00/0
This article has been cited by other articles:
R. Nargeot, C. Petrissans, and J. Simmers
Behavioral and In Vitro Correlates of Compulsive-Like Food Seeking Induced by Operant Conditioning in Aplysia
J. Neurosci., July 25, 2007; 27(30): 8059 - 8070.
[Abstract] [Full Text] [PDF]
G. E. Serrano, C. Martinez-Rubio, and M. W. Miller
Endogenous Motor Neuron Properties Contribute to a Program-Specific Phase of Activity in the Multifunctional Feeding Central Pattern Generator of Aplysia
J Neurophysiol, July 1, 2007; 98(1): 29 - 42.
[Abstract] [Full Text] [PDF]
D. A. Baxter and J. H. Byrne
Feeding behavior of Aplysia: A model system for comparing cellular mechanisms of classical and operant conditioning
Learn. Mem., November 1, 2006; 13(6): 669 - 680.
[Abstract] [Full Text] [PDF]
M. Diaz-Rios and M. W. Miller
Target-Specific Regulation of Synaptic Efficacy in the Feeding Central Pattern Generator of Aplysia: Potential Substrates for Behavioral Plasticity?
Biol. Bull., June 1, 2006; 210(3): 215 - 229.
[Abstract] [Full Text] [PDF]
R. D. Hawkins, G. A. Clark, and E. R. Kandel
Operant Conditioning of Gill Withdrawal in Aplysia
J. Neurosci., March 1, 2006; 26(9): 2443 - 2448.
[Abstract] [Full Text] [PDF]
F. D. Reyes, R. Mozzachiodi, D. A. Baxter, and J. H. Byrne
Reinforcement in an in vitro analog of appetitive classical conditioning of feeding behavior in Aplysia: Blockade by a dopamine antagonist
Learn. Mem., May 1, 2005; 12(3): 216 - 220.
[Abstract] [Full Text] [PDF]
M. Diaz-Rios and M. W. Miller
Rapid Dopaminergic Signaling by Interneurons That Contain Markers for Catecholamines and GABA in the Feeding Circuitry of Aplysia
J Neurophysiol, April 1, 2005; 93(4): 2142 - 2156.
[Abstract] [Full Text] [PDF]
B. Brembs, D. A. Baxter, and J. H. Byrne
Extending In Vitro Conditioning in Aplysia to Analyze Operant and Classical Processes in the Same Preparation
Learn. Mem., July 1, 2004; 11(4): 412 - 420.
[Abstract] [Full Text] [PDF]
R. Mozzachiodi, H. A. Lechner, D. A. Baxter, and J. H. Byrne
In Vitro Analog of Classical Conditioning of Feeding Behavior in Aplysia
Learn. Mem., November 1, 2003; 10(6): 478 - 494.
[Abstract] [Full Text] [PDF]
D. Barbas, L. DesGroseillers, V. F. Castellucci, T. J. Carew, and S. Marinesco
Multiple Serotonergic Mechanisms Contributing to Sensitization in Aplysia: Evidence of Diverse Serotonin Receptor Subtypes
Learn. Mem., September 1, 2003; 10(5): 373 - 386.
[Abstract] [Full Text] [PDF]
G. E. Spencer, M. H. Kazmi, N. I. Syed, and K. Lukowiak
Changes in the Activity of a CPG Neuron After the Reinforcement of an Operantly Conditioned Behavior in Lymnaea
J Neurophysiol, October 1, 2002; 88(4): 1915 - 1923.
[Abstract] [Full Text] [PDF]
B. Brembs, F. D. Lorenzetti, F. D. Reyes, D. A. Baxter, and J. H. Byrne
Operant Reward Learning in Aplysia: Neuronal Correlates and Mechanisms
Science, May 31, 2002; 296(5573): 1706 - 1709.
[Abstract] [Full Text] [PDF]
C. J. H. Elliott and A. J. Susswein
Comparative neuroethology of feeding control in molluscs
J. Exp. Biol., April 1, 2002; 205(7): 877 - 896.
[Abstract] [Full Text] [PDF]
N. Jones, G. Kemenes, and P. R. Benjamin
Selective Expression of Electrical Correlates of Differential Appetitive Classical Conditioning in a Feeding Network
J Neurophysiol, January 1, 2001; 85(1): 89 - 97.
[Abstract] [Full Text] [PDF]
H. A. Lechner, D. A. Baxter, and J. H. Byrne
Classical Conditioning of Feeding in Aplysia: I. Behavioral Analysis
J. Neurosci., May 1, 2000; 20(9): 3369 - 3376.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|