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Published Online
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June 3, 2002
 Previous Article
The Journal of Neuroscience, 2002, 22:RC230:1-6
RAPID COMMUNICATION
Two-State Membrane Potential Transitions of Striatal Spiny
Neurons as Evidenced by Numerical Simulations and Electrophysiological
Recordings in Awake Monkeys
Katsunori
Kitano1,
Hideyuki
Câteau1, 2,
Katsuyuki
Kaneda2, 3,
Atsushi
Nambu2, 3,
Masahiko
Takada2, 3, and
Tomoki
Fukai1, 2
1 Department of Information-Communication Engineering,
Tamagawa University, Machida, Tokyo 194-8610, Japan, 2 Core
Research for Evolutional Science and Technology, Japan Science and
Technology Corporation, Kawaguchi, Saitama 332-0012, Japan, and
3 Department of System Neuroscience, Tokyo Metropolitan
Institute for Neuroscience, Tokyo Metropolitan Organization for Medical
Research, Fuchu, Tokyo 183-8526, Japan
Spontaneous membrane potential fluctuations of striatal spiny
projection neurons play a crucial role in their spike generation. Previous intracellular recording studies in anesthetized rats have
shown that the membrane potential of striatal spiny neurons shifts
between the depolarized "up" state and the hyperpolarized "down" state. Here we report evidence for the occurrence of such two-state membrane potential transitions by numerical simulations and
electrophysiological recordings in awake monkeys. Data from our
simulations of a striatal spiny neuron model demonstrated that spike
latency histograms of the model neuron displayed two separate (i.e.,
early and late) peaks in response to excitatory cortical input,
corresponding to neuronal activity in the up or down state,
respectively. Then, we addressed experimentally whether the latency
distribution of cortically induced spike firing of striatal spiny
neurons might show dual peaks. Striatal neuron activity was
extracellularly recorded in response to electrical stimulation in the
two cortical motor-related areas, the primary motor cortex and the
supplementary motor area, of awake monkeys. Analysis of spike latency
histograms has defined that striatal spiny neurons typically exhibit
two temporally distinct peaks, as obtained by the numerical
simulations. Thus, the membrane potential shifts between the up and
down states appear to occur in striatal spiny neurons of the behaving animal.
Key words:
striatal spiny projection neuron; corticostriatal input; multicompartment neuron model; extracellular recording; spike latency
histogram; awake monkey
Copyright © Society for Neuroscience 0270-6474//$05.00/0
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