QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

Published Online
on June 3, 2002

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kitano, K. Articles by Fukai, T. Search for Related Content PubMed Articles by Kitano, K. Articles by Fukai, T.

 Previous Article

The Journal of Neuroscience, 2002, 22:RC230:1-6

RAPID COMMUNICATION
Two-State Membrane Potential Transitions of Striatal Spiny Neurons as Evidenced by Numerical Simulations and Electrophysiological Recordings in Awake Monkeys

Katsunori Kitano¹, Hideyuki Câteau^{1, 2}, Katsuyuki Kaneda^{2, 3}, Atsushi Nambu^{2, 3}, Masahiko Takada^{2, 3}, and Tomoki Fukai^{1, 2}

¹ Department of Information-Communication Engineering, Tamagawa University, Machida, Tokyo 194-8610, Japan, ² Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi, Saitama 332-0012, Japan, and ³ Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183-8526, Japan

Spontaneous membrane potential fluctuations of striatal spiny projection neurons play a crucial role in their spike generation. Previous intracellular recording studies in anesthetized rats have shown that the membrane potential of striatal spiny neurons shifts between the depolarized "up" state and the hyperpolarized "down" state. Here we report evidence for the occurrence of such two-state membrane potential transitions by numerical simulations and electrophysiological recordings in awake monkeys. Data from our simulations of a striatal spiny neuron model demonstrated that spike latency histograms of the model neuron displayed two separate (i.e., early and late) peaks in response to excitatory cortical input, corresponding to neuronal activity in the up or down state, respectively. Then, we addressed experimentally whether the latency distribution of cortically induced spike firing of striatal spiny neurons might show dual peaks. Striatal neuron activity was extracellularly recorded in response to electrical stimulation in the two cortical motor-related areas, the primary motor cortex and the supplementary motor area, of awake monkeys. Analysis of spike latency histograms has defined that striatal spiny neurons typically exhibit two temporally distinct peaks, as obtained by the numerical simulations. Thus, the membrane potential shifts between the up and down states appear to occur in striatal spiny neurons of the behaving animal.

Key words: striatal spiny projection neuron; corticostriatal input; multicompartment neuron model; extracellular recording; spike latency histogram; awake monkey

---

Copyright © Society for Neuroscience  0270-6474//$05.00/0

This article has been cited by other articles:

				L. Liang, M. R. DeLong, and S. M. Papa Inversion of Dopamine Responses in Striatal Medium Spiny Neurons and Involuntary Movements J. Neurosci., July 23, 2008; 28(30): 7537 - 7547. [Abstract] [Full Text] [PDF]

				S. Mahon, N. Vautrelle, L. Pezard, S. J. Slaght, J.-M. Deniau, G. Chouvet, and S. Charpier Distinct Patterns of Striatal Medium Spiny Neuron Activity during the Natural Sleep-Wake Cycle J. Neurosci., November 29, 2006; 26(48): 12587 - 12595. [Abstract] [Full Text] [PDF]

				J. N. D. Kerr and D. Plenz Action Potential Timing Determines Dendritic Calcium during Striatal Up-States J. Neurosci., January 28, 2004; 24(4): 877 - 885. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help