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Next Article 
The Journal of Neuroscience, January 1, 2001, 21(1):1-9
A Calcium-Dependent Feedback Mechanism Participates in Shaping
Single NMDA Miniature EPSCs
Masashi
Umemiya1,
Nansheng
Chen2,
Lynn A.
Raymond2, and
Timothy H.
Murphy2
1 Department of Neurophysiology, Tohoku University
School of Medicine, Sendai 980-8575, Japan, and 2 Kinsmen
Laboratory Department of Physiology and Psychiatry, University of
British Columbia, Vancouver, Canada V6T 1Z3
NMDA receptors (NMDARs) are highly calcium-permeable and are
negatively regulated by intracellular calcium during prolonged exposure
to agonist. We have investigated whether calcium-mediated feedback
occurs during transient exposure to glutamate during single synaptic
events. Examination of miniature EPSCs (mEPSCs) indicated that
the decay kinetics of the NMDAR component was markedly slowed by the
intracellular perfusion of exogenous calcium buffers (BAPTA or Fluo-3).
In contrast, the AMPA receptor component of the miniature EPSC was
unaffected. Slow on-rate calcium buffers, such as EGTA, did not alter
kinetics of the NMDAR component of the mEPSC. Addition of exogenous
fast calcium buffers did not slow the decay kinetics of
glutamate-evoked currents mediated by NR1/NR2A heteromers expressed in
HEK 293 cells, suggesting that the effect we observed in neurons
may be specific to processes associated with synaptically activated
receptors. Trial-to-trial amplitude variability of miniature calcium
transients mediated by NMDARs increased with the injection of exogenous
calcium buffers, suggesting that the amplitude of synaptic calcium
transients are maintained at a rather constant level by a
calcium-mediated feedback mechanism.
Key words:
NMDA receptors; calcium; NR2A; Fluo-3; glutamate
receptor; development
Copyright © 2001 Society for Neuroscience 0270-6474/01/2111-09$05.00/0
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X. D. Li and J. J. Buccafusco
Role of {alpha}7 Nicotinic Acetylcholine Receptors in the Pressor Response to Intracerebroventricular Injection of Choline: Blockade by Amyloid Peptide A{beta}1-42
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M. Galante and M. A. Diana
Group I Metabotropic Glutamate Receptors Inhibit GABA Release at Interneuron-Purkinje Cell Synapses through Endocannabinoid Production
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E. A. Budygin, M. S. Brodie, T. D. Sotnikova, Y. Mateo, C. E. John, M. Cyr, R. R. Gainetdinov, and S. R. Jones
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S. Seeber, A. Humeny, M. Herkert, T. Rau, T. Eschenhagen, and C.-M. Becker
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K. K. Yoder, C. Wang, and E. D. Morris
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R. W. Schnepp, H. Mao, S. M. Sykes, W.-X. Zong, A. Silva, P. La, and X. Hua
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R. L. C. Mitchell, R. Elliott, M. Barry, A. Cruttenden, and P. W. R. Woodruff
Neural response to emotional prosody in schizophrenia and in bipolar affective disorder
The British Journal of Psychiatry,
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T. Nevian and B. Sakmann
Single Spine Ca2+ Signals Evoked by Coincident EPSPs and Backpropagating Action Potentials in Spiny Stellate Cells of Layer 4 in the Juvenile Rat Somatosensory Barrel Cortex
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S. Partida-Sanchez, P. Iribarren, M. E. Moreno-Garcia, J.-L. Gao, P. M. Murphy, N. Oppenheimer, J. M. Wang, and F. E. Lund
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G. Kristo, Y. Yoshimura, J. Niu, B. J. Keith, R. M. Mentzer Jr., R. Bunger, and R. D. Lasley
The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium
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M. Derrick, N. L. Luo, J. C. Bregman, T. Jilling, X. Ji, K. Fisher, C. L. Gladson, D. J. Beardsley, G. Murdoch, S. A. Back, et al.
Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy?
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I. K. Goerendt, A. D. Lawrence, and D. J. Brooks
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P. Iribarren, Y.-H. Cui, Y. Le, G. Ying, X. Zhang, W. Gong, and J. M. Wang
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G. McGuire, H. El-Beheiry, P. Manninen, A. Lozano, and R. Wennberg
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P. Brambilla, J. Perez, S. Monchieri, P.M. Rossini, and C. Bonato
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S. D. Sullivan, R. A. DeFazio, and S. M. Moenter
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F Sotty, M Danik, F Manseau, F Laplante, R Quirion, and S Williams
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F. Grassi, E. Palma, R. Tonini, M. Amici, M. Ballivet, and F. Eusebi
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E. Bastia and M. A. Schwarzschild
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D. E. Chapman, K. A. Keefe, and K. S. Wilcox
Evidence for Functionally Distinct Synaptic NMDA Receptors in Ventromedial Versus Dorsolateral Striatum
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K. J. Black, T. Hershey, J. M. Koller, T. O. Videen, M. A. Mintun, J. L. Price, and J. S. Perlmutter
A possible substrate for dopamine-related changes in mood and behavior: Prefrontal and limbic effects of a D3-preferring dopamine agonist
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L J Shanley, D O'Malley, A J Irving, M L Ashford, and J Harvey
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J. P. Mitchell, T. F. Heatherton, and C. N. Macrae
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Y. Konishi, K. Lindholm, L.-B. Yang, R. Li, and Y. Shen
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B. K. Rycroft and A. J. Gibb
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Y. Goto and P. O'Donnell
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K.-j. Yin, S.-D. Chen, J.-M. Lee, J. Xu, and C. Y. Hsu
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F. Kasanetz, L. A Riquelme, and M G. Murer
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Y.-K. Ng, X. Lu, and E. S Levitan
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S. Wang, Z. Jia, J. Roder, and T. H. Murphy
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B. D. Corneil, M. Van Wanrooij, D. P. Munoz, and A. J. Van Opstal
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J. P. Dilger
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E. Davids, K. Zhang, N. S. Kula, F. I. Tarazi, and R. J. Baldessarini
Effects of Norepinephrine and Serotonin Transporter Inhibitors on Hyperactivity Induced by Neonatal 6-Hydroxydopamine Lesioning in Rats
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M. Cassidy, P. Mazzone, A. Oliviero, A. Insola, P. Tonali, V. D. Lazzaro, and P. Brown
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