 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, January 1, 2001, 21(1):109-116
Localization and Mechanisms of Action of Cannabinoid Receptors at the Glutamatergic Synapses of the Mouse Nucleus Accumbens
David Robbe1, Gérard Alonso2, Florence Duchamp2, Joël Bockaert1, and Olivier J. Manzoni1 Centre National de la Recherche Scientifique 1 Unité Propre de Recherche 9023 and 2 Unité Mixte de Recherche 5101, 34094 Montpellier Cedex 05, France
Despite the role of excitatory transmission to the nucleus accumbens (NAc) in the actions of most drugs of abuse, the presence and functions of cannabinoid receptors (CB1) on the glutamatergic cortical afferents to the NAc have never been explored. Here, immunohistochemistry has been used to show the localization of CB1 receptors on axonal terminals making contacts with the NAc GABAergic neurons. Electrophysiological techniques in the NAc slice preparation revealed that cannabimimetics [WIN 55,212,2 (WIN-2) and CP55940] strongly inhibit stimulus-evoked glutamate-mediated transmission. The inhibitory actions of WIN-2 were dose-dependent (EC50 of 293 ± 13 nM) and reversed by the selective CB1 antagonist SR 141716A. In agreement with a presynaptic localization of CB1 receptors, WIN-2 increased paired-pulse facilitation, decreased miniature EPSC (mEPSC) frequency, and had no effect on the mEPSCs amplitude. Perfusion with the adenylate cyclase activator forskolin enhanced glutamatergic transmission but did not alter presynaptic CB1 actions, suggesting that cannabinoids inhibit glutamate release independently from the cAMP-PKA cascade. CB1 did not reduce evoked transmitter release by inhibiting presynaptic voltage-dependent Ca2+ currents through N-, L-, or P/Q-type Ca2+ channels, because CB1 inhibition persisted in the presence of
-Conotoxin-GVIA, nimodipine, or
Key words: nucleus accumbens; cannabinoid; glutamate; CB1 receptors; presynaptic inhibition; K+ channels; mice
Copyright © 2001 Society for Neuroscience 0270-6474/01/211109-08$05.00/0
This article has been cited by other articles:
H. Yasuda, Y. Huang, and T. Tsumoto
Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus
PNAS, February 26, 2008; 105(8): 3106 - 3111.
[Abstract] [Full Text] [PDF]
A.-G. Corbille, E. Valjent, G. Marsicano, C. Ledent, B. Lutz, D. Herve, and J.-A. Girault
Role of Cannabinoid Type 1 Receptors in Locomotor Activity and Striatal Signaling in Response to Psychostimulants
J. Neurosci., June 27, 2007; 27(26): 6937 - 6947.
[Abstract] [Full Text] [PDF]
S. Singla, A. C. Kreitzer, and R. C. Malenka
Mechanisms for Synapse Specificity during Striatal Long-Term Depression
J. Neurosci., May 9, 2007; 27(19): 5260 - 5264.
[Abstract] [Full Text] [PDF]
H. Huang, C. Acuna-Goycolea, Y. Li, H. M. Cheng, K. Obrietan, and A. N. van den Pol
Cannabinoids Excite Hypothalamic Melanin-Concentrating Hormone But Inhibit Hypocretin/Orexin Neurons: Implications for Cannabinoid Actions on Food Intake and Cognitive Arousal
J. Neurosci., May 2, 2007; 27(18): 4870 - 4881.
[Abstract] [Full Text] [PDF]
S. Caille, L. Alvarez-Jaimes, I. Polis, D. G. Stouffer, and L. H. Parsons
Specific Alterations of Extracellular Endocannabinoid Levels in the Nucleus Accumbens by Ethanol, Heroin, and Cocaine Self-Administration
J. Neurosci., April 4, 2007; 27(14): 3695 - 3702.
[Abstract] [Full Text] [PDF]
M. E. Hofmann, B. Nahir, and C. J. Frazier
Endocannabinoid-Mediated Depolarization-Induced Suppression of Inhibition in Hilar Mossy Cells of the Rat Dentate Gyrus
J Neurophysiol, November 1, 2006; 96(5): 2501 - 2512.
[Abstract] [Full Text] [PDF]
P. Pacher, S. Batkai, and G. Kunos
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pharmacol. Rev., September 1, 2006; 58(3): 389 - 462.
[Abstract] [Full Text] [PDF]
Z.-X. Xi, J. G. Gilbert, X.-Q. Peng, A. C. Pak, X. Li, and E. L. Gardner
Cannabinoid CB1 Receptor Antagonist AM251 Inhibits Cocaine-Primed Relapse in Rats: Role of Glutamate in the Nucleus Accumbens.
J. Neurosci., August 15, 2006; 26(33): 8531 - 8536.
[Abstract] [Full Text] [PDF]
M. R. Domenici, S. C. Azad, G. Marsicano, A. Schierloh, C. T. Wotjak, H.-U. Dodt, W. Zieglgansberger, B. Lutz, and G. Rammes
Cannabinoid Receptor Type 1 Located on Presynaptic Terminals of Principal Neurons in the Forebrain Controls Glutamatergic Synaptic Transmission
J. Neurosci., May 24, 2006; 26(21): 5794 - 5799.
[Abstract] [Full Text] [PDF]
M. Yamasaki, K. Hashimoto, and M. Kano
Miniature Synaptic Events Elicited by Presynaptic Ca2+ Rise Are Selectively Suppressed by Cannabinoid Receptor Activation in Cerebellar Purkinje Cells
J. Neurosci., January 4, 2006; 26(1): 86 - 95.
[Abstract] [Full Text] [PDF]
S. Di, C. Boudaba, I. R. Popescu, F.-J. Weng, C. Harris, V. L. Marcheselli, N. G. Bazan, and J. G. Tasker
Activity-dependent release and actions of endocannabinoids in the rat hypothalamic supraoptic nucleus
J. Physiol., December 15, 2005; 569(3): 751 - 760.
[Abstract] [Full Text] [PDF]
A. C. Kreitzer and R. C. Malenka
Dopamine Modulation of State-Dependent Endocannabinoid Release and Long-Term Depression in the Striatum
J. Neurosci., November 9, 2005; 25(45): 10537 - 10545.
[Abstract] [Full Text] [PDF]
A. Kofalvi, R. J. Rodrigues, C. Ledent, K. Mackie, E. S. Vizi, R. A. Cunha, and B. Sperlagh
Involvement of Cannabinoid Receptors in the Regulation of Neurotransmitter Release in the Rodent Striatum: A Combined Immunochemical and Pharmacological Analysis
J. Neurosci., March 16, 2005; 25(11): 2874 - 2884.
[Abstract] [Full Text] [PDF]
D. A. Fortin, J. Trettel, and E. S. Levine
Brief Trains of Action Potentials Enhance Pyramidal Neuron Excitability Via Endocannabinoid-Mediated Suppression of Inhibition
J Neurophysiol, October 1, 2004; 92(4): 2105 - 2112.
[Abstract] [Full Text] [PDF]
C. Kushmerick, G. D. Price, H. Taschenberger, N. Puente, R. Renden, J. I. Wadiche, R. M. Duvoisin, P. Grandes, and H. von Gersdorff
Retroinhibition of Presynaptic Ca2+ Currents by Endocannabinoids Released via Postsynaptic mGluR Activation at a Calyx Synapse
J. Neurosci., June 30, 2004; 24(26): 5955 - 5965.
[Abstract] [Full Text] [PDF]
S. P. Brown, P. K. Safo, and W. G. Regehr
Endocannabinoids Inhibit Transmission at Granule Cell to Purkinje Cell Synapses by Modulating Three Types of Presynaptic Calcium Channels
J. Neurosci., June 16, 2004; 24(24): 5623 - 5631.
[Abstract] [Full Text] [PDF]
I. A. Khasabova, C. Harding-Rose, D. A. Simone, and V. S. Seybold
Differential Effects of CB1 and Opioid Agonists on Two Populations of Adult Rat Dorsal Root Ganglion Neurons
J. Neurosci., February 18, 2004; 24(7): 1744 - 1753.
[Abstract] [Full Text] [PDF]
Y.-C. Liang, C.-C. Huang, K.-S. Hsu, and T. Takahashi
Cannabinoid-induced presynaptic inhibition at the primary afferent trigeminal synapse of juvenile rat brainstem slices
J. Physiol., February 15, 2004; 555(1): 85 - 96.
[Abstract] [Full Text] [PDF]
J. Cami and M. Farre
Drug Addiction
N. Engl. J. Med., September 4, 2003; 349(10): 975 - 986.
[Full Text] [PDF]
T. F. FREUND, I. KATONA, and D. PIOMELLI
Role of Endogenous Cannabinoids in Synaptic Signaling
Physiol Rev, July 1, 2003; 83(3): 1017 - 1066.
[Abstract] [Full Text] [PDF]
A. F. Hoffman, M. Oz, T. Caulder, and C. R. Lupica
Functional Tolerance and Blockade of Long-Term Depression at Synapses in the Nucleus Accumbens after Chronic Cannabinoid Exposure
J. Neurosci., June 15, 2003; 23(12): 4815 - 4820.
[Abstract] [Full Text] [PDF]
G. O. Hjelmstad and H. L. Fields
Kappa Opioid Receptor Activation in the Nucleus Accumbens Inhibits Glutamate and GABA Release Through Different Mechanisms
J Neurophysiol, May 1, 2003; 89(5): 2389 - 2395.
[Abstract] [Full Text] [PDF]
D. J. Rademacher, S. Patel, F. A. Hopp, C. Dean, C. J. Hillard, and J. L. Seagard
Microinjection of a cannabinoid receptor antagonist into the NTS increases baroreflex duration in dogs
Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1570 - H1576.
[Abstract] [Full Text] [PDF]
S. C. Azad, M. Eder, G. Marsicano, B. Lutz, W. Zieglgansberger, and G. Rammes
Activation of the Cannabinoid Receptor Type 1 Decreases Glutamatergic and GABAergic Synaptic Transmission in the Lateral Amygdala of the Mouse
Learn. Mem., March 1, 2003; 10(2): 116 - 128.
[Abstract] [Full Text] [PDF]
L. Zhang and R. A. Warren
Muscarinic and Nicotinic Presynaptic Modulation of EPSCs in the Nucleus Accumbens During Postnatal Development
J Neurophysiol, December 1, 2002; 88(6): 3315 - 3330.
[Abstract] [Full Text] [PDF]
D. Robbe, M. Kopf, A. Remaury, J. Bockaert, and O. J. Manzoni
Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
PNAS, June 11, 2002; 99(12): 8384 - 8388.
[Abstract] [Full Text] [PDF]
D. Robbe, G. Alonso, S. Chaumont, J. Bockaert, and O. J. Manzoni
Role of P/Q-Ca2+ Channels in Metabotropic Glutamate Receptor 2/3-Dependent Presynaptic Long-Term Depression at Nucleus Accumbens Synapses
J. Neurosci., June 1, 2002; 22(11): 4346 - 4356.
[Abstract] [Full Text] [PDF]
A. C. Howlett, F. Barth, T. I. Bonner, G. Cabral, P. Casellas, W. A. Devane, C. C. Felder, M. Herkenham, K. Mackie, B. R. Martin, et al.
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Pharmacol. Rev., June 1, 2002; 54(2): 161 - 202.
[Abstract] [Full Text] [PDF]
C.-C. Huang, Y.-L. Chen, S.-W. Lo, and K.-S. Hsu
Activation of cAMP-Dependent Protein Kinase Suppresses the Presynaptic Cannabinoid Inhibition of Glutamatergic Transmission at Corticostriatal Synapses
Mol. Pharmacol., March 1, 2002; 61(3): 578 - 585.
[Abstract] [Full Text] [PDF]
P. Congar, A. Bergevin, and L.-E. Trudeau
D2 Receptors Inhibit the Secretory Process Downstream From Calcium Influx in Dopaminergic Neurons: Implication of K+ Channels
J Neurophysiol, February 1, 2002; 87(2): 1046 - 1056.
[Abstract] [Full Text] [PDF]
S. Ghozland, H. W. D. Matthes, F. Simonin, D. Filliol, B. L. Kieffer, and R. Maldonado
Motivational Effects of Cannabinoids Are Mediated by {micro}-Opioid and kappa -Opioid Receptors
J. Neurosci., February 1, 2002; 22(3): 1146 - 1154.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|