 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 1, 2001, 21(1):201-214
Cell-Cycle Kinetics of Neocortical Precursors Are Influenced by Embryonic Thalamic Axons
Colette Dehay1, Pierre Savatier2, Véronique Cortay1, and Henry Kennedy1 1 Institut National de la Santé et de la Recherche Médicale U371, Cerveau et Vision, 69500 Bron, France, and 2 Ecole Normale Supérieure de Lyon Laboratoire de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5665, 69364 Lyon Cedex 07, France
Thalamic afferents are known to exert a control over the differentiation of cortical areas at late stages of development. Here, we show that thalamic afferents also influence early stages of corticogenesis at the level of the ventricular zone. Using an in vitro approach, we show that embryonic day 14 mouse thalamic axons release a diffusable factor that promotes the proliferation of cortical precursors over a restricted developmental window. The thalamic mitogenic effect on cortical precursors (1) shortens the total cell-cycle duration via a reduction of the G1 phase; (2) facilitates the G1/S transition leading to an increase in proliferative divisions; (3) is significantly reduced by antibodies directed against bFGF; and (4) influences the proliferation of both glial and neuronal precursors and does not preclude the action of signals that induce differentiation in these two lineages. We have related these in vitro findings to the in vivo condition: the organotypic culture of cortical explants in which anatomical thalamocortical innervation is preserved shows significantly increased proliferation rates compared with cortical explants devoid of subcortical afferents. These results are in line with a number of studies at subcortical levels showing the control of neurogenesis via afferent fibers in both vertebrates and invertebrates. Specifically, they indicate the mechanisms whereby embryonic thalamic afferents contribute to the known early regionalization of the ventricular zone, which plays a major role in the specification of neocortical areas.
Key words: development; cortex; proliferation; areal specification; mouse; ventricular zone
Copyright © 2001 Society for Neuroscience 0270-6474/01/211201-14$05.00/0
This article has been cited by other articles:
S. Horng, G. Kreiman, C. Ellsworth, D. Page, M. Blank, K. Millen, and M. Sur
Differential Gene Expression in the Developing Lateral Geniculate Nucleus and Medial Geniculate Nucleus Reveals Novel Roles for Zic4 and Foxp2 in Visual and Auditory Pathway Development
J. Neurosci., October 28, 2009; 29(43): 13672 - 13683.
[Abstract] [Full Text] [PDF]
T. Kowalczyk, A. Pontious, C. Englund, R. A. M. Daza, F. Bedogni, R. Hodge, A. Attardo, C. Bell, W. B. Huttner, and R. F. Hevner
Intermediate Neuronal Progenitors (Basal Progenitors) Produce Pyramidal-Projection Neurons for All Layers of Cerebral Cortex
Cereb Cortex, October 1, 2009; 19(10): 2439 - 2450.
[Abstract] [Full Text] [PDF]
M. R. Costa, O. Bucholz, T. Schroeder, and M. Gotz
Late Origin of Glia-Restricted Progenitors in the Developing Mouse Cerebral Cortex
Cereb Cortex, July 1, 2009; 19(suppl_1): i135 - i143.
[Abstract] [Full Text] [PDF]
J. N. Pulvers and W. B. Huttner
Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors
Development, June 1, 2009; 136(11): 1859 - 1868.
[Abstract] [Full Text] [PDF]
J. Kaslin, J. Ganz, and M. Brand
Proliferation, neurogenesis and regeneration in the non-mammalian vertebrate brain
Phil Trans R Soc B, January 12, 2008; 363(1489): 101 - 122.
[Abstract] [Full Text] [PDF]
R. Toro and Y. Burnod
A Morphogenetic Model for the Development of Cortical Convolutions
Cereb Cortex, December 1, 2005; 15(12): 1900 - 1913.
[Abstract] [Full Text] [PDF]
J. A. Siegenthaler and M. W. Miller
Transforming Growth Factor {beta}1 Promotes Cell Cycle Exit through the Cyclin-Dependent Kinase Inhibitor p21 in the Developing Cerebral Cortex
J. Neurosci., September 21, 2005; 25(38): 8627 - 8636.
[Abstract] [Full Text] [PDF]
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420.
[Abstract] [Full Text] [PDF]
F. Calegari and W. B. Huttner
An inhibition of cyclin-dependent kinases that lengthens, but does not arrest, neuroepithelial cell cycle induces premature neurogenesis
J. Cell Sci., December 15, 2003; 116(24): 4947 - 4955.
[Abstract] [Full Text] [PDF]
S. Garel, K. J. Huffman, and J. L. R. Rubenstein
Molecular regionalization of the neocortex is disrupted in Fgf8 hypomorphic mutants
Development, May 1, 2003; 130(9): 1903 - 1914.
[Abstract] [Full Text] [PDF]
A. Lukaszewicz, P. Savatier, V. Cortay, H. Kennedy, and C. Dehay
Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells
J. Neurosci., August 1, 2002; 22(15): 6610 - 6622.
[Abstract] [Full Text] [PDF]
R. Belvindrah, G. Rougon, and G. Chazal
Increased Neurogenesis in Adult mCD24-Deficient Mice
J. Neurosci., May 1, 2002; 22(9): 3594 - 3607.
[Abstract] [Full Text] [PDF]
I. H.M. Smart, C. Dehay, P. Giroud, M. Berland, and H. Kennedy
Unique Morphological Features of the Proliferative Zones and Postmitotic Compartments of the Neural Epithelium Giving Rise to Striate and Extrastriate Cortex in the Monkey
Cereb Cortex, January 1, 2002; 12(1): 37 - 53.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|