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The Journal of Neuroscience, January 1, 2001, 21(1):270-278

Amygdalar Efferents Initiate Auditory Thalamic Discriminative Training-Induced Neuronal Activity

Amy Poremba¹ and Michael Gabriel²

¹ Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, and ² Department of Psychology and Beckman Institute, University of Illinois, Urbana, Illinois 61821

It is well known that neurons of the medial geniculate (MG) nucleus of the thalamus send axonal projections to the amygdala. It has been proposed that these projections supply information that supports amygdalar associative processes underlying acquisition of acoustically cued conditioning and learning. Here we demonstrate the reverse direction of influence. Temporary inactivation of the amygdala using the GABA_A receptor agonist muscimol just before the onset of discriminative avoidance conditioning permanently blocked the development of training-induced discriminative neuronal activity in the MG nucleus of rabbits. No discriminative activity developed when the amygdala was inactivated or during later training to criterion without muscimol. Thus, amygdalar processing at the outset of training is necessary for the development of training-induced discriminative activity of neurons in the MG nucleus.

Key words: muscimol; GABA_A agonist; temporary lesion; rabbits; associative conditioning; retention; multiunit neuronal activity

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Copyright © 2001 Society for Neuroscience  0270-6474/01/211270-09$05.00/0

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