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The Journal of Neuroscience, January 1, 2001, 21(1):84-91
Fornix-Dependent Induction of Hippocampal CCAAT Enhancer-Binding
Protein  and  Co-Localizes with Phosphorylated cAMP Response
Element-Binding Protein and Accompanies Long-Term Memory
Consolidation
Stephen M.
Taubenfeld1,
Kjesten A.
Wiig2,
Barbara
Monti1,
Bridget
Dolan1,
Gabriella
Pollonini1, and
Cristina M.
Alberini1
1 Department of Neuroscience and 2 Howard
Hughes Medical Institute, Brown University, Providence, Rhode Island
02912
The cAMP response element-binding protein (CREB) is an
evolutionarily conserved transcription regulator essential for
long-term memory formation. It is not known, however, whether the
molecular events downstream of CREB activation are also conserved. An
early, cAMP-dependent event necessary for learning-related long-term synaptic plasticity in the invertebrate Aplysia
californica is the induction of the transcription factor CCAAT
enhancer-binding protein (C/EBP). Here we show that two homologs in the
rat, C/EBP and C/EBP , are induced at discrete times after
inhibitory avoidance learning and co-localize with phosphorylated CREB
in the hippocampus. This induction is blocked by fornix lesions, which
are known to disrupt activation of CREB in the hippocampus and to
impair memory consolidation. These results indicate that C/EBPs are
evolutionarily conserved components of the CREB-dependent gene cascade
activated in long-term memory.
Key words:
C/EBP; CREB; learning and memory; inhibitory avoidance; fornix; lesion; hippocampus; rat
Copyright © 2001 Society for Neuroscience 0270-6474/01/21184-08$05.00/0
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