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The Journal of Neuroscience, May 15, 2001, 21(10):3342-3349
High-Fidelity Transmission Acquired via a Developmental Decrease
in NMDA Receptor Expression at an Auditory Synapse
Kensuke
Futai,
Masayoshi
Okada,
Kyoko
Matsuyama, and
Tomoyuki
Takahashi
Department of Neurophysiology, University of Tokyo Faculty of
Medicine, Tokyo 113-0033, Japan
Central auditory relay synapses in mature animals follow
high-frequency inputs for computation of sound localization. In
immature mice, however, transmission at the calyx of Held synapse in
auditory brainstem was inaccurate for high-frequency inputs because the summed slow synaptic potential components caused aberrant firings or
blocked action potentials. As the mice matured, synaptic potentials became shorter, with smaller and faster NMDA receptor
components, thereby establishing the precise one-to-one transmission
for high-frequency inputs. Developmental acquisition of this
high-fidelity transmission could be mimicked experimentally in
immature mice by blocking NMDA receptors with
D( )2-amino-5-phosphonovaleric acid (D-APV). Furthermore, bilateral cochlear ablations at postnatal day 7 (P7) attenuated the developmental decrease of NMDA receptor expression and
prevented the acquisition of high-fidelity transmission. We suggest
that auditory activity, which begins at P10-P12 in mice, downregulates
the expression of postsynaptic NMDA receptors, thereby contributing to
the establishment of high-fidelity synaptic transmission.
Key words:
NMDA receptor; high-fidelity synaptic transmission; postnatal development; the calyx of Held; cochlear ablation; excitatory
postsynaptic current; AMPA receptor
Copyright © 2001 Society for Neuroscience 0270-6474/01/21103342-08$05.00/0
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