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The Journal of Neuroscience, May 15, 2001, 21(10):3697-3703

Reinforcement of Early Long-Term Potentiation (Early-LTP) in Dentate Gyrus by Stimulation of the Basolateral Amygdala: Heterosynaptic Induction Mechanisms of Late-LTP

Sabine Frey¹, Jorge Bergado-Rosado², Thomas Seidenbecher³, Hans-Christian Pape³, and J. Uwe Frey¹

¹ Leibniz-Institute for Neurobiology, Department of Neurophysiology, PF 1860, D-39008 Magdeburg, Germany, ² Centro Internacional de Restauración Neurológica CIREN, Laboratory of Experimental Electrophysiology, CH21, Havana, Cuba, and ³ Institute for Physiology, Medical Faculty of the Otto-von-Guericke-University, 39120 Magdeburg, Germany

The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and -adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.

Key words: long-term potentiation; reinforcement; heterosynaptic LTP; associative LTP; late-LTP; basolateral amygdala; hippocampus; dentate gyrus

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21103697-07$05.00/0

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