 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, June 1, 2001, 21(11):3771-3779
Metabotropic Glutamate Receptor Subtypes 1 and 5 Are Activators of Extracellular Signal-Regulated Kinase Signaling Required for Inflammatory Pain in Mice
Farzana Karim, Chia-Chuan Wang, and Robert W. Gereau IV Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
Metabotropic glutamate receptors are expressed abundantly in the spinal cord and have been shown to play important roles in the modulation of nociceptive transmission and plasticity. Most previous studies have focused on the group I metabotropic glutamate receptors (mGluR1 and mGluR5) and activation of phospholipase C signaling by these receptors in modulating nociception. Recently, it was shown that the extracellular signal-regulated kinases (ERKs)/mitogen-activated protein kinases are activated in spinal cord dorsal horn neurons in response to stimulation of nociceptors and that ERK signaling is involved in nociceptive plasticity. In the present studies, we sought to test the hypothesis that group I mGluRs modulate nociceptive transmission or plasticity via modulation of ERK signaling in dorsal horn neurons. We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord. Furthermore, we find that inflammation-evoked ERK activation, which is required for nociceptive plasticity, is downstream of mGluR1 and mGluR5. Finally, we show colocalization of group I mGluRs with activated ERK in dorsal horn neurons. These results show that mGluR1 and mGluR5 are activated in dorsal horn neurons in response to peripheral inflammation and that activation of these group I mGluRs leads to activation of ERK1 and ERK2, resulting in enhanced pain sensitivity.
Key words: extracellular signal-regulated kinases (ERKs); mitogen-activated protein kinase (MAPK); nociception; formalin test; spinal cord; dorsal horn
Copyright © 2001 Society for Neuroscience 0270-6474/01/21113771-09$05.00/0
This article has been cited by other articles:
Y.-J. Gao, L. Zhang, O. A. Samad, M. R. Suter, K. Yasuhiko, Z.-Z. Xu, J.-Y. Park, A.-L. Lind, Q. Ma, and R.-R. Ji
JNK-Induced MCP-1 Production in Spinal Cord Astrocytes Contributes to Central Sensitization and Neuropathic Pain
J. Neurosci., April 1, 2009; 29(13): 4096 - 4108.
[Abstract] [Full Text] [PDF]
H. Cao, Y.-J. Gao, W.-H. Ren, T.-T. Li, K.-Z. Duan, Y.-H. Cui, X.-H. Cao, Z.-Q. Zhao, R.-R. Ji, and Y.-Q. Zhang
Activation of Extracellular Signal-Regulated Kinase in the Anterior Cingulate Cortex Contributes to the Induction and Expression of Affective Pain
J. Neurosci., March 11, 2009; 29(10): 3307 - 3321.
[Abstract] [Full Text] [PDF]
F. Ferraguti, L. Crepaldi, and F. Nicoletti
Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
Pharmacol. Rev., December 1, 2008; 60(4): 536 - 581.
[Abstract] [Full Text] [PDF]
A. R. Ferguson, K. A. Bolding, J. R. Huie, M. A. Hook, D. R. Santillano, R. C. Miranda, and J. W. Grau
Group I Metabotropic Glutamate Receptors Control Metaplasticity of Spinal Cord Learning through a Protein Kinase C-Dependent Mechanism
J. Neurosci., November 12, 2008; 28(46): 11939 - 11949.
[Abstract] [Full Text] [PDF]
G.-D. Chen, M.-L. Peng, P.-Y. Wang, S.-D. Lee, H.-M. Chang, S.-F. Pan, M.-J. Chen, K.-C. Tung, C.-Y. Lai, and T.-B. Lin
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R487 - R493.
[Abstract] [Full Text] [PDF]
T. J. Price, M. H. Rashid, M. Millecamps, R. Sanoja, J. M. Entrena, and F. Cervero
Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR
J. Neurosci., December 19, 2007; 27(51): 13958 - 13967.
[Abstract] [Full Text] [PDF]
H.-J. Hu, B. J. Alter, Y. Carrasquillo, C.-S. Qiu, and R. W. Gereau IV
Metabotropic Glutamate Receptor 5 Modulates Nociceptive Plasticity via Extracellular Signal-Regulated Kinase Kv4.2 Signaling in Spinal Cord Dorsal Horn Neurons
J. Neurosci., November 28, 2007; 27(48): 13181 - 13191.
[Abstract] [Full Text] [PDF]
B. H. Gabra, F. K. Kessler, J. K. Ritter, W. L. Dewey, and F. L. Smith
Decrease in N-Methyl-D-aspartic Acid Receptor-NR2B Subunit Levels by Intrathecal Short-Hairpin RNA Blocks Group I Metabotropic Glutamate Receptor-Mediated Hyperalgesia
J. Pharmacol. Exp. Ther., July 1, 2007; 322(1): 186 - 194.
[Abstract] [Full Text] [PDF]
T. Mizushima, K. Obata, H. Katsura, J. Sakurai, K. Kobayashi, H. Yamanaka, Y. Dai, T. Fukuoka, T. Mashimo, and K. Noguchi
Intensity-Dependent Activation of Extracellular Signal-Regulated Protein Kinase 5 in Sensory Neurons Contributes to Pain Hypersensitivity
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 28 - 34.
[Abstract] [Full Text] [PDF]
L.-Y. Qiao and M. A. Gulick
Region-specific changes in the phosphorylation of ERK1/2 and ERK5 in rat micturition pathways following cyclophosphamide-induced cystitis
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1368 - R1375.
[Abstract] [Full Text] [PDF]
Y. Carrasquillo and R. W. Gereau IV
Activation of the Extracellular Signal-Regulated Kinase in the Amygdala Modulates Pain Perception
J. Neurosci., February 14, 2007; 27(7): 1543 - 1551.
[Abstract] [Full Text] [PDF]
J. Bonnefont, L. Daulhac, M. Etienne, E. Chapuy, C. Mallet, L. Ouchchane, C. Deval, J.-P. Courade, M. Ferrara, A. Eschalier, et al.
Acetaminophen Recruits Spinal p42/p44 MAPKs and GH/IGF-1 Receptors to Produce Analgesia via the Serotonergic System
Mol. Pharmacol., February 1, 2007; 71(2): 407 - 415.
[Abstract] [Full Text] [PDF]
Y. H. Zhang, J. C. Fehrenbacher, M. R. Vasko, and G. D. Nicol
Sphingosine-1-Phosphate Via Activation of a G-Protein-Coupled Receptor(s) Enhances the Excitability of Rat Sensory Neurons
J Neurophysiol, September 1, 2006; 96(3): 1042 - 1052.
[Abstract] [Full Text] [PDF]
L. J. Volk, C. A. Daly, and K. M. Huber
Differential Roles for Group 1 mGluR Subtypes in Induction and Expression of Chemically Induced Hippocampal Long-Term Depression
J Neurophysiol, April 1, 2006; 95(4): 2427 - 2438.
[Abstract] [Full Text] [PDF]
Y. Kawasaki, T. Kohno, and R.-R. Ji
Different Effects of Opioid and Cannabinoid Receptor Agonists on C-Fiber-Induced Extracellular Signal-Regulated Kinase Activation in Dorsal Horn Neurons in Normal and Spinal Nerve-Ligated Rats
J. Pharmacol. Exp. Ther., February 1, 2006; 316(2): 601 - 607.
[Abstract] [Full Text] [PDF]
F. Wei, K. I. Vadakkan, H. Toyoda, L.-J. Wu, M.-G. Zhao, H. Xu, F. W.F. Shum, Y. H. Jia, and M. Zhuo
Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to Activation of Extracellular Signal-Regulated Kinase in Spinal Dorsal Horn Neurons in Adult Rats and Mice
J. Neurosci., January 18, 2006; 26(3): 851 - 861.
[Abstract] [Full Text] [PDF]
Y. Zhang, A. L. Rodriguez, and P. J. Conn
Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 5 Have Differential Effects on Different Signaling Pathways in Cortical Astrocytes
J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1212 - 1219.
[Abstract] [Full Text] [PDF]
W. Guo, F. Wei, S. Zou, M. T. Robbins, S. Sugiyo, T. Ikeda, J.-C. Tu, P. F. Worley, R. Dubner, and K. Ren
Group I Metabotropic Glutamate Receptor NMDA Receptor Coupling and Signaling Cascade Mediate Spinal Dorsal Horn NMDA Receptor 2B Tyrosine Phosphorylation Associated with Inflammatory Hyperalgesia
J. Neurosci., October 13, 2004; 24(41): 9161 - 9173.
[Abstract] [Full Text] [PDF]
R.-R. Ji and G. Strichartz
Cell Signaling and the Genesis of Neuropathic Pain
Sci. Signal., September 28, 2004; 2004(252): re14 - re14.
[Abstract] [Full Text] [PDF]
Y. Kawasaki, T. Kohno, Z.-Y. Zhuang, G. J. Brenner, H. Wang, C. Van Der Meer, K. Befort, C. J. Woolf, and R.-R. Ji
Ionotropic and Metabotropic Receptors, Protein Kinase A, Protein Kinase C, and Src Contribute to C-Fiber-Induced ERK Activation and cAMP Response Element-Binding Protein Phosphorylation in Dorsal Horn Neurons, Leading to Central Sensitization
J. Neurosci., September 22, 2004; 24(38): 8310 - 8321.
[Abstract] [Full Text] [PDF]
S. M. Gallagher, C. A. Daly, M. F. Bear, and K. M. Huber
Extracellular Signal-Regulated Protein Kinase Activation Is Required for Metabotropic Glutamate Receptor-Dependent Long-Term Depression in Hippocampal Area CA1
J. Neurosci., May 19, 2004; 24(20): 4859 - 4864.
[Abstract] [Full Text] [PDF]
W. Li and V. Neugebauer
Differential Roles of mGluR1 and mGluR5 in Brief and Prolonged Nociceptive Processing in Central Amygdala Neurons
J Neurophysiol, January 1, 2004; 91(1): 13 - 24.
[Abstract] [Full Text]
M. Miyata, H. Kashiwadani, M. Fukaya, T. Hayashi, D. Wu, T. Suzuki, M. Watanabe, and Y. Kawakami
Role of Thalamic Phospholipase C{beta}4 Mediated by Metabotropic Glutamate Receptor Type 1 in Inflammatory Pain
J. Neurosci., September 3, 2003; 23(22): 8098 - 8108.
[Abstract] [Full Text] [PDF]
H.-J. Hu, K. S. Glauner, and R. W. Gereau IV
ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. I. Modulation of A-Type K+ Currents
J Neurophysiol, September 1, 2003; 90(3): 1671 - 1679.
[Abstract] [Full Text] [PDF]
H.-J. Hu and R. W. Gereau IV
ERK Integrates PKA and PKC Signaling in Superficial Dorsal Horn Neurons. II. Modulation of Neuronal Excitability
J Neurophysiol, September 1, 2003; 90(3): 1680 - 1688.
[Abstract] [Full Text] [PDF]
S.-X. Jin, Z.-Y. Zhuang, C. J. Woolf, and R.-R. Ji
p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain
J. Neurosci., May 15, 2003; 23(10): 4017 - 4022.
[Abstract] [Full Text] [PDF]
R. F. De Jongh, K. C. Vissers, T. F. Meert, L. H. D. J. Booij, C. S. De Deyne, and R. J. Heylen
The Role of Interleukin-6 in Nociception and Pain
Anesth. Analg., April 1, 2003; 96(4): 1096 - 1103.
[Abstract] [Full Text] [PDF]
J. L. Berkeley and A. I. Levey
Cell-Specific Extracellular Signal-Regulated Kinase Activation by Multiple G Protein-Coupled Receptor Families in Hippocampus
Mol. Pharmacol., January 1, 2003; 63(1): 128 - 135.
[Abstract] [Full Text] [PDF]
J. J. Anderson, S. P. Rao, B. Rowe, D. R. Giracello, G. Holtz, D. F. Chapman, L. Tehrani, M. J. Bradbury, N. D. P. Cosford, and M. A. Varney
[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization
J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1044 - 1051.
[Abstract] [Full Text] [PDF]
H.-J. Hu, G. Bhave, and R. W. Gereau IV
Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia
J. Neurosci., September 1, 2002; 22(17): 7444 - 7452.
[Abstract] [Full Text] [PDF]
Y. Dai, K. Iwata, T. Fukuoka, E. Kondo, A. Tokunaga, H. Yamanaka, T. Tachibana, Y. Liu, and K. Noguchi
Phosphorylation of Extracellular Signal-Regulated Kinase in Primary Afferent Neurons by Noxious Stimuli and Its Involvement in Peripheral Sensitization
J. Neurosci., September 1, 2002; 22(17): 7737 - 7745.
[Abstract] [Full Text] [PDF]
L. Fagni, P. F. Worley, and F. Ango
Homer as Both a Scaffold and Transduction Molecule
Sci. Signal., June 18, 2002; 2002(137): re8 - re8.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|