 |
||||
|
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, June 1, 2001, 21(11):4059-4065
Large Involuntary Forces Consistent with Plateau-Like Behavior of Human Motoneurons
D. F. Collins, D. Burke, and S. C. Gandevia Spinal Injury Research Centre, Prince of Wales Medical Research Institute and University of New South Wales, Randwick, Sydney, Australia 2031
When electrical stimulation is applied over human muscle, the evoked force is generally considered to be of peripheral origin. However, in relaxed humans, stimulation (1 msec pulses, 100 Hz) over the muscles that plantarflex the ankle produced more than five times more force than could be accounted for by peripheral properties. This additional force was superimposed on the direct response to motor axon stimulation, produced up to 40% of the force generated during a maximal voluntary contraction, and was abolished during anesthesia of the tibial nerve proximal to the stimulation site. It therefore must have resulted from the activation of motoneurons within the spinal cord. The additional force could be initiated by stimulation of low-threshold afferents, distorted the classical relationship between force and stimulus frequency, and often outlasted the stimulation. The mean firing rate of 27 soleus motor units recorded during the sustained involuntary activity after the stimulation was 5.8 ± 0.2 Hz. The additional force increments were not attributable to voluntary intervention because they were present in three sleeping subjects and in two subjects with lesions of the thoracic spinal cord. The phenomenon is consistent with activation of plateau potentials within motoneurons and, if so, the present findings imply that plateau potentials can make a large contribution to forces produced by the human nervous system.
Key words: human; motoneuron; muscle force; spinal cord; reflex; muscle contraction; plateau potential
Copyright © 2001 Society for Neuroscience 0270-6474/01/21114059-07$05.00/0
This article has been cited by other articles:
O. Lagerquist, L. D. Walsh, J.-S. Blouin, D. F. Collins, and S. C. Gandevia
Effect of a peripheral nerve block on torque produced by repetitive electrical stimulation
J Appl Physiol, July 1, 2009; 107(1): 161 - 167.
[Abstract] [Full Text] [PDF]
V. A. Selionov, Y. P. Ivanenko, I. A. Solopova, and V. S. Gurfinkel
Tonic Central and Sensory Stimuli Facilitate Involuntary Air-Stepping in Humans
J Neurophysiol, June 1, 2009; 101(6): 2847 - 2858.
[Abstract] [Full Text] [PDF]
J.-S. Blouin, L. D. Walsh, P. Nickolls, and S. C. Gandevia
High-frequency submaximal stimulation over muscle evokes centrally generated forces in human upper limb skeletal muscles
J Appl Physiol, February 1, 2009; 106(2): 370 - 377.
[Abstract] [Full Text] [PDF]
R. K. Powers
"Extra" force evoked by percutaneous muscle stimulation: mechanisms and potential therapeutic applications
J Appl Physiol, February 1, 2009; 106(2): 353 - 355.
[Full Text] [PDF]
J. G. McPherson, M. D. Ellis, C. J. Heckman, and J. P. A. Dewald
Evidence for Increased Activation of Persistent Inward Currents in Individuals With Chronic Hemiparetic Stroke
J Neurophysiol, December 1, 2008; 100(6): 3236 - 3243.
[Abstract] [Full Text] [PDF]
C.J. Heckman, M. Johnson, C. Mottram, and J. Schuster
Persistent Inward Currents in Spinal Motoneurons and Their Influence on Human Motoneuron Firing Patterns
Neuroscientist, June 1, 2008; 14(3): 264 - 275.
[Abstract] [PDF]
B. Javan and E. P. Zehr
Short-Term Plasticity of Spinal Reflex Excitability Induced by Rhythmic Arm Movement
J Neurophysiol, April 1, 2008; 99(4): 2000 - 2005.
[Abstract] [Full Text] [PDF]
J. L. Taylor
Magnetic muscle stimulation produces fatigue without effort
J Appl Physiol, September 1, 2007; 103(3): 733 - 734.
[Full Text] [PDF]
J. C. Dean, L. M. Yates, and D. F. Collins
Turning on the central contribution to contractions evoked by neuromuscular electrical stimulation
J Appl Physiol, July 1, 2007; 103(1): 170 - 176.
[Abstract] [Full Text] [PDF]
P. M. Klakowicz, E. R. L. Baldwin, and D. F. Collins
Contribution of M-Waves and H-Reflexes to Contractions Evoked by Tetanic Nerve Stimulation in Humans
J Neurophysiol, September 1, 2006; 96(3): 1293 - 1302.
[Abstract] [Full Text] [PDF]
E. R. L. Baldwin, P. M. Klakowicz, and D. F. Collins
Wide-pulse-width, high-frequency neuromuscular stimulation: implications for functional electrical stimulation
J Appl Physiol, July 1, 2006; 101(1): 228 - 240.
[Abstract] [Full Text] [PDF]
J. Gondin, J. Duclay, and A. Martin
Soleus- and Gastrocnemii-Evoked V-Wave Responses Increase After Neuromuscular Electrical Stimulation Training
J Neurophysiol, June 1, 2006; 95(6): 3328 - 3335.
[Abstract] [Full Text] [PDF]
T. G. Hornby, J. H. Kahn, M. Wu, and B. D. Schmit
Temporal facilitation of spastic stretch reflexes following human spinal cord injury
J. Physiol., March 15, 2006; 571(3): 593 - 604.
[Abstract] [Full Text] [PDF]
A. J. Fuglevand, A. P. Dutoit, R. K. Johns, and D. A. Keen
Evaluation of plateau-potential-mediated 'warm up' in human motor units
J. Physiol., March 15, 2006; 571(3): 683 - 693.
[Abstract] [Full Text] [PDF]
S. Rossignol, R. Dubuc, and J.-P. Gossard
Dynamic Sensorimotor Interactions in Locomotion
Physiol Rev, January 1, 2006; 86(1): 89 - 154.
[Abstract] [Full Text] [PDF]
J. A. Bamford, C. T. Putman, and V. K. Mushahwar
Intraspinal microstimulation preferentially recruits fatigue-resistant muscle fibres and generates gradual force in rat
J. Physiol., December 15, 2005; 569(3): 873 - 884.
[Abstract] [Full Text] [PDF]
T. G. Hornby, V. M. Tysseling-Mattiace, E. N. Benz, and B. D. Schmit
Contribution of Muscle Afferents to Prolonged Flexion Withdrawal Reflexes in Human Spinal Cord Injury
J Neurophysiol, December 1, 2004; 92(6): 3375 - 3384.
[Abstract] [Full Text] [PDF]
P. Nickolls, D. F. Collins, R. B. Gorman, D. Burke, and S. C. Gandevia
Forces consistent with plateau-like behaviour of spinal neurons evoked in patients with spinal cord injuries
Brain, March 1, 2004; 127(3): 660 - 670.
[Abstract] [Full Text] [PDF]
B. D. Schmit, T. G. Hornby, V. M. Tysseling-Mattiace, and E. N. Benz
Absence of Local Sign Withdrawal in Chronic Human Spinal Cord Injury
J Neurophysiol, November 1, 2003; 90(5): 3232 - 3241.
[Abstract] [Full Text] [PDF]
D. Nozaki, N. Kawashima, Y. Aramaki, M. Akai, K. Nakazawa, Y. Nakajima, and H. Yano
Sustained Muscle Contractions Maintained by Autonomous Neuronal Activity Within the Human Spinal Cord
J Neurophysiol, October 1, 2003; 90(4): 2090 - 2097.
[Abstract] [Full Text] [PDF]
I. Zijdewind and C. K. Thomas
Motor Unit Firing During and After Voluntary Contractions of Human Thenar Muscles Weakened by Spinal Cord Injury
J Neurophysiol, April 1, 2003; 89(4): 2065 - 2071.
[Abstract] [Full Text] [PDF]
R. H. Lee, J. J. Kuo, M. C. Jiang, and C. J. Heckman
Influence of Active Dendritic Currents on Input-Output Processing in Spinal Motoneurons In Vivo
J Neurophysiol, January 1, 2003; 89(1): 27 - 39.
[Abstract] [Full Text] [PDF]
T. G. Hornby, W. Z. Rymer, E. N. Benz, and B. D. Schmit
Windup of Flexion Reflexes in Chronic Human Spinal Cord Injury: A Marker for Neuronal Plateau Potentials?
J Neurophysiol, January 1, 2003; 89(1): 416 - 426.
[Abstract] [Full Text] [PDF]
K. E. Jones, A. F. d. C. Hamilton, and D. M. Wolpert
Sources of Signal-Dependent Noise During Isometric Force Production
J Neurophysiol, September 1, 2002; 88(3): 1533 - 1544.
[Abstract] [Full Text] [PDF]
D F Collins, D Burke, and S C Gandevia
Sustained contractions produced by plateau-like behaviour in human motoneurones
J. Physiol., January 1, 2002; 538(1): 289 - 301.
[Abstract] [Full Text] [PDF]
S. C. Gandevia
Spinal and Supraspinal Factors in Human Muscle Fatigue
Physiol Rev, October 1, 2001; 81(4): 1725 - 1789.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|