QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (31) Citing Articles via Google Scholar Google Scholar Articles by Wang, G.-Y. Articles by Chalupa, L. M. Search for Related Content PubMed PubMed Citation Articles by Wang, G.-Y. Articles by Chalupa, L. M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 15, 2001, 21(12):4310-4317

Unique Functional Properties of On and Off Pathways in the Developing Mammalian Retina

Guo-Yong Wang, Lauren C. Liets, and Leo M. Chalupa

Section of Neurobiology, Physiology, and Behavior, Division of Biological Sciences and Ophthalmology Department, School of Medicine, University of California, Davis, Davis, California 95616

In the mature retina, the dendrites of On and Off ganglion cells are segregated into separate sublaminas of the inner plexiform layer, but early in development these processes are multistratified, ramifying more widely within this synaptic layer. The dendritic pattern exhibited by immature ganglion cells suggests that there may be a functional convergence of On and Off pathways in the developing retina, but previous studies have provided evidence against this. Here we demonstrate by patch-clamp recordings and dye filling that ganglion cells with multistratified dendrites respond to the onset, as well as the offset, of light. We further show that, in the dark-adapted retina, the glutamate analog 2-amino-4-phosphonobutric acid abolishes On and Off discharges in ganglion cells with multistratified dendrites. In contrast, in cells with stratified dendrites, this drug selectively blocks On responses. These findings provide evidence for unique functional attributes of On and Off pathways in the developing retina. The properties of immature ganglion cells documented here have important implications for the roles ascribed to neuronal activity in refining connections during the early development of the visual system.

Key words: development; retinal ganglion cell; APB; dendritic stratification; On and Off pathways; retina; visual system

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21124310-08$05.00/0

This article has been cited by other articles:

				S. Di Marco, V. A. Nguyen, S. Bisti, and D. A. Protti Permanent Functional Reorganization of Retinal Circuits Induced by Early Long-Term Visual Deprivation J. Neurosci., October 28, 2009; 29(43): 13691 - 13701. [Abstract] [Full Text] [PDF]

				C. Sun, C. M. Speer, G.-Y. Wang, B. Chapman, and L. M. Chalupa Epibatidine Application In Vitro Blocks Retinal Waves Without Silencing All Retinal Ganglion Cell Action Potentials in Developing Retina of the Mouse and Ferret J Neurophysiol, December 1, 2008; 100(6): 3253 - 3263. [Abstract] [Full Text] [PDF]

				N. Tian Synaptic activity, visual experience and the maturation of retinal synaptic circuitry J. Physiol., September 15, 2008; 586(18): 4347 - 4355. [Abstract] [Full Text] [PDF]

				B. Werner, P. B. Cook, and C. L. Passaglia Complex Temporal Response Patterns With a Simple Retinal Circuit J Neurophysiol, August 1, 2008; 100(2): 1087 - 1097. [Abstract] [Full Text] [PDF]

				D. A. Protti, N. Flores-Herr, W. Li, S. C. Massey, and H. Wassle Light Signaling in Scotopic Conditions in the Rabbit, Mouse and Rat Retina: A Physiological and Anatomical Study J Neurophysiol, June 1, 2005; 93(6): 3479 - 3488. [Abstract] [Full Text] [PDF]

				H. Xu and N. Tian Pathway-Specific Maturation, Visual Deprivation, and Development of Retinal Pathway Neuroscientist, August 1, 2004; 10(4): 337 - 346. [Abstract] [PDF]

				C. J. Akerman, M. S. Grubb, and I. D. Thompson Spatial and Temporal Properties of Visual Responses in the Thalamus of the Developing Ferret J. Neurosci., January 7, 2004; 24(1): 170 - 182. [Abstract] [Full Text] [PDF]

				L. C. Liets, B. A. Olshausen, G.-Y. Wang, and L. M. Chalupa Spontaneous Activity of Morphologically Identified Ganglion Cells in the Developing Ferret Retina J. Neurosci., August 13, 2003; 23(19): 7343 - 7350. [Abstract] [Full Text] [PDF]

				G.-Y. Wang, L. C. Liets, and L. M. Chalupa Nitric Oxide Differentially Modulates ON and OFF Responses of Retinal Ganglion Cells J Neurophysiol, August 1, 2003; 90(2): 1304 - 1313. [Abstract] [Full Text] [PDF]

				M. Seki, H. Nawa, T. Fukuchi, H. Abe, and N. Takei BDNF is Upregulated by Postnatal Development and Visual Experience: Quantitative and Immunohistochemical Analyses of BDNF in the Rat Retina Invest. Ophthalmol. Vis. Sci., July 1, 2003; 44(7): 3211 - 3218. [Abstract] [Full Text] [PDF]

				E. Gunhan, P. V. Choudary, T. E. Landerholm, and L. M. Chalupa Depletion of Cholinergic Amacrine Cells by a Novel Immunotoxin Does Not Perturb the Formation of Segregated On and Off Cone Bipolar Cell Projections J. Neurosci., March 15, 2002; 22(6): 2265 - 2273. [Abstract] [Full Text] [PDF]

				K. L. Myhr, P. D. Lukasiewicz, and R. O. L. Wong Mechanisms Underlying Developmental Changes in the Firing Patterns of ON and OFF Retinal Ganglion Cells during Refinement of their Central Projections J. Neurosci., November 1, 2001; 21(21): 8664 - 8671. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help