QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (40) Citing Articles via Google Scholar Google Scholar Articles by Bouzioukh, F. Articles by Rougon, G. Search for Related Content PubMed PubMed Citation Articles by Bouzioukh, F. Articles by Rougon, G. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB NITRIC OXIDE

 Previous Article  |  Next Article 

The Journal of Neuroscience, July 1, 2001, 21(13):4721-4730

NMDA Receptor and Nitric Oxide Synthase Activation Regulate Polysialylated Neural Cell Adhesion Molecule Expression in Adult Brainstem Synapses

Farima Bouzioukh^{1, 2}, Fabien Tell¹, André Jean¹, and Geneviève Rougon²

¹ Laboratoire de Neurobiologie des Fonctions Végétatives, Faculté de Saint Jérôme, Centre National de la Recherche Scientifique (CNRS) Formation de Recherche en Évolution 2132-Unité Sous Contrat Institut National de la Recherche Agronomique 1147, 13397 Marseille, Cedex 20, France, and ² Laboratoire de Génétique et Physiologie du Développement, Institut de Biologie du Développement de Marseille, CNRS Unité Mixte de Recherche 6545, Parc Scientifique de Luminy, 13288 Marseille, Cedex 09, France

Here we report that synapses in the adult dorsal vagal complex, a gateway for many primary afferent fibers, express a high level of the polysialylated neural cell adhesion molecule (PSA-NCAM). We show that electrical stimulation of the vagal afferents causes a rapid decrease of PSA-NCAM expression both in vivo and in acute slices. Inhibition of NMDA receptor activity completely prevented the decrease. Blockade of calmodulin activation, neuronal nitric oxide (NO) synthase, or soluble guanylyl cyclase and chelation of extracellular NO mimicked this inhibition. Our data provide a mechanistic framework for understanding how activity-linked stimulation of the NMDA-NO-cGMP pathway induces rapid changes in PSA-NCAM expression, which may be associated with long-term depression.

Key words: adhesion molecules; NMDAR; NO; plasticity; dorsal vagal complex; PSA-NCAM

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21134721-10$05.00/0

This article has been cited by other articles:

				F. Papastefanaki, J. Chen, A. A. Lavdas, D. Thomaidou, M. Schachner, and R. Matsas Grafts of Schwann cells engineered to express PSA-NCAM promote functional recovery after spinal cord injury Brain, August 1, 2007; 130(8): 2159 - 2174. [Abstract] [Full Text] [PDF]

				M. A. Lopez-Fernandez, M.-F. Montaron, E. Varea, G. Rougon, C. Venero, D. N. Abrous, and C. Sandi Upregulation of Polysialylated Neural Cell Adhesion Molecule in the Dorsal Hippocampus after Contextual Fear Conditioning Is Involved in Long-Term Memory Formation J. Neurosci., April 25, 2007; 27(17): 4552 - 4561. [Abstract] [Full Text] [PDF]

				M. S. L. Hammond, C. Sims, K. Parameshwaran, V. Suppiramaniam, M. Schachner, and A. Dityatev Neural Cell Adhesion Molecule-associated Polysialic Acid Inhibits NR2B-containing N-Methyl-D-aspartate Receptors and Prevents Glutamate-induced Cell Death J. Biol. Chem., November 17, 2006; 281(46): 34859 - 34869. [Abstract] [Full Text] [PDF]

				C. Sandi, M. I. Cordero, J. J. Merino, N. D. Kruyt, C. M. Regan, and K. J. Murphy Neurobiological and Endocrine Correlates of Individual Differences in Spatial Learning Ability Learn. Mem., May 1, 2004; 11(3): 244 - 252. [Abstract] [Full Text] [PDF]

				P. Charles, R. Reynolds, D. Seilhean, G. Rougon, M. S. Aigrot, A. Niezgoda, B. Zalc, and C. Lubetzki Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis? Brain, September 1, 2002; 125(9): 1972 - 1979. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help