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The Journal of Neuroscience, July 1, 2001, 21(13):4721-4730

NMDA Receptor and Nitric Oxide Synthase Activation Regulate Polysialylated Neural Cell Adhesion Molecule Expression in Adult Brainstem Synapses

Farima Bouzioukh^{1, 2}, Fabien Tell¹, André Jean¹, and Geneviève Rougon²

¹ Laboratoire de Neurobiologie des Fonctions Végétatives, Faculté de Saint Jérôme, Centre National de la Recherche Scientifique (CNRS) Formation de Recherche en Évolution 2132-Unité Sous Contrat Institut National de la Recherche Agronomique 1147, 13397 Marseille, Cedex 20, France, and ² Laboratoire de Génétique et Physiologie du Développement, Institut de Biologie du Développement de Marseille, CNRS Unité Mixte de Recherche 6545, Parc Scientifique de Luminy, 13288 Marseille, Cedex 09, France

Here we report that synapses in the adult dorsal vagal complex, a gateway for many primary afferent fibers, express a high level of the polysialylated neural cell adhesion molecule (PSA-NCAM). We show that electrical stimulation of the vagal afferents causes a rapid decrease of PSA-NCAM expression both in vivo and in acute slices. Inhibition of NMDA receptor activity completely prevented the decrease. Blockade of calmodulin activation, neuronal nitric oxide (NO) synthase, or soluble guanylyl cyclase and chelation of extracellular NO mimicked this inhibition. Our data provide a mechanistic framework for understanding how activity-linked stimulation of the NMDA-NO-cGMP pathway induces rapid changes in PSA-NCAM expression, which may be associated with long-term depression.

Key words: adhesion molecules; NMDAR; NO; plasticity; dorsal vagal complex; PSA-NCAM

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21134721-10$05.00/0

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