 |
 Previous Article | Next Article 
The Journal of Neuroscience, July 1, 2001, 21(13):4883-4890
Dissociation between Light-Induced Phase Shift of the Circadian
Rhythm and Clock Gene Expression in Mice Lacking the Pituitary
Adenylate Cyclase Activating Polypeptide Type 1 Receptor
Jens
Hannibal1,
Francoise
Jamen2,
Harriette
S.
Nielsen1,
Laurant
Journot2,
Philippe
Brabet2, and
Jan
Fahrenkrug1
1 Department of Clinical Biochemistry, Bispebjerg
Hospital, University of Copenhagen, DK-2400 Copenhagen, Denmark, and
2 Unité Propre de Recherche 9023, Centre National de
la Recherche Scientifique, 34094 Montpellier Cedex 5, France
The circadian clock located in the suprachiasmatic nucleus (SCN)
organizes autonomic and behavioral rhythms into a near 24 hr time that
is adjusted daily to the solar cycle via a direct projection from the
retina, the retinohypothalamic tract (RHT). This neuronal pathway
costores the neurotransmitters PACAP and glutamate, which seem to be
important for light-induced resetting of the clock. At the molecular
level the clock genes mPer1 and mPer2 are
believed to be target for the light signaling to the clock. In this
study, we investigated the possible role of PACAP-type 1 receptor
signaling in light-induced resetting of the behavioral rhythm and
light-induced clock gene expression in the SCN. Light stimulation at
early night resulted in larger phase delays in PACAP-type 1 receptor-deficient mice
(PAC1 /)
compared with wild-type mice accompanied by a marked reduction in light-induced mPer1, mPer2, and
c-fos gene expression. Light stimulation at late night
induced mPer1 and c-fos gene expression in the SCN to the same levels in both wild type and
PAC1/ mice.
However, in contrast to the phase advance seen in wild-type mice,
PAC1/ mice
responded with phase delays after photic stimulation. These data
indicate that PAC1 receptor signaling participates in
the gating control of photic sensitivity of the clock and suggest that
mPer1, mPer2, and c-fos
are of less importance for light-induced phase shifts at night.
Key words:
retinohypothalamic tract; suprachiasmatic nucleus; clock
genes; knock-out; mouse; light entrainment
Copyright © 2001 Society for Neuroscience 0270-6474/01/21134883-08$05.00/0
This article has been cited by other articles:
|
|
|
|
 
D. Vaudry, A. Falluel-Morel, S. Bourgault, M. Basille, D. Burel, O. Wurtz, A. Fournier, B. K. C. Chow, H. Hashimoto, L. Galas, et al.
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
Pharmacol. Rev.,
September 1, 2009;
61(3):
283 - 357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Beaule, J. W. Mitchell, P. T. Lindberg, R. Damadzic, L. E. Eiden, and M. U. Gillette
Temporally restricted role of retinal PACAP: integration of the phase-advancing light signal to the SCN.
J Biol Rhythms,
April 1, 2009;
24(2):
126 - 134.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. Hannibal, P. Brabet, and J. Fahrenkrug
Mice lacking the PACAP type I receptor have impaired photic entrainment and negative masking
Am J Physiol Regulatory Integrative Comp Physiol,
December 1, 2008;
295(6):
R2050 - R2058.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Brown, C. S. Colwell, J. A. Waschek, and H. D. Piggins
Disrupted Neuronal Activity Rhythms in the Suprachiasmatic Nuclei of Vasoactive Intestinal Polypeptide-Deficient Mice
J Neurophysiol,
March 1, 2007;
97(3):
2553 - 2558.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H.-Y. M. Cheng, H. Dziema, J. Papp, D. P. Mathur, M. Koletar, M. R. Ralph, J. M. Penninger, and K. Obrietan
The Molecular Gatekeeper Dexras1 Sculpts the Photic Responsiveness of the Mammalian Circadian Clock
J. Neurosci.,
December 13, 2006;
26(50):
12984 - 12995.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Levi
PACAP enlightenment of mouse circadian clock
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 2004;
287(5):
R1033 - R1034.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Colwell, S. Michel, J. Itri, W. Rodriguez, J. Tam, V. Lelievre, Z. Hu, and J. A. Waschek
Selective deficits in the circadian light response in mice lacking PACAP
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 2004;
287(5):
R1194 - R1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. T. Hughes, B. Fahey, D. J. Cutler, A. N. Coogan, and H. D. Piggins
Aberrant Gating of Photic Input to the Suprachiasmatic Circadian Pacemaker of Mice Lacking the VPAC2 Receptor
J. Neurosci.,
April 7, 2004;
24(14):
3522 - 3526.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Isojima, N. Okumura, and K. Nagai
Molecular Mechanism of Mammalian Circadian Clock
J. Biochem.,
December 1, 2003;
134(6):
777 - 784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. S. Colwell, S. Michel, J. Itri, W. Rodriguez, J. Tam, V. Lelievre, Z. Hu, X. Liu, and J. A. Waschek
Disrupted circadian rhythms in VIP- and PHI-deficient mice
Am J Physiol Regulatory Integrative Comp Physiol,
November 1, 2003;
285(5):
R939 - R949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. H. Meijer and W. J. Schwartz
In Search of the Pathways for Light-Induced Pacemaker Resetting in the Suprachiasmatic Nucleus
J Biol Rhythms,
June 1, 2003;
18(3):
235 - 249.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V. Simonneaux and C. Ribelayga
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters
Pharmacol. Rev.,
June 1, 2003;
55(2):
325 - 395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Bae and D. R. Weaver
Light-Induced Phase Shifts in Mice Lacking mPER1 or mPER2
J Biol Rhythms,
April 1, 2003;
18(2):
123 - 133.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. N. Coogan and H. D. Piggins
Circadian and Photic Regulation of Phosphorylation of ERK1/2 and Elk-1 in the Suprachiasmatic Nuclei of the Syrian Hamster
J. Neurosci.,
April 1, 2003;
23(7):
3085 - 3093.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Asnicar, A. Koster, M. L. Heiman, F. Tinsley, D. P. Smith, E. Galbreath, N. Fox, Y. L. Ma, W. F. Blum, and H. M. Hsiung
Vasoactive Intestinal Polypeptide/Pituitary Adenylate Cyclase-Activating Peptide Receptor 2 Deficiency in Mice Results in Growth Retardation and Increased Basal Metabolic Rate
Endocrinology,
October 1, 2002;
143(10):
3994 - 4006.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Hannibal, P. Hindersson, S. M. Knudsen, B. Georg, and J. Fahrenkrug
The Photopigment Melanopsin Is Exclusively Present in Pituitary Adenylate Cyclase-Activating Polypeptide-Containing Retinal Ganglion Cells of the Retinohypothalamic Tract
J. Neurosci.,
January 1, 2002;
22(1):
RC191 - RC191.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
