QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (40) Citing Articles via Google Scholar Google Scholar Articles by Parish, C. L. Articles by Horne, M. K. Search for Related Content PubMed PubMed Citation Articles by Parish, C. L. Articles by Horne, M. K.

 Previous Article  |  Next Article 

The Journal of Neuroscience, July 15, 2001, 21(14):5147-5157

The Role of Dopamine Receptors in Regulating the Size of Axonal Arbors

C. L. Parish¹, D. I. Finkelstein¹, J. Drago^{1, 2}, E. Borrelli³, and M. K. Horne^{1, 2}

¹ Neurosciences Group, Department of Medicine and ² Department of Neurology, Monash Medical Center, Clayton 3168, Australia, and ³ Institut de Génétique et de Biologie Moléculaire et Cellulaire, 67404 Illkirch Cedex, France

Factors that regulate terminal arbor size of substantia nigra pars compacta (SNpc) neurons during development and after injury are not well understood. This study examined the role of dopamine receptors in regulating arbor size. Terminal arbors were examined in mice with targeted deletion of the D1 or D2 dopamine receptor [D1(/) and D2(/) mice, respectively]. Terminal trees were also examined after treatment with receptor blockers and after partial SNpc lesions. Immunohistochemistry was performed, and the number of SNpc neurons and dopaminergic terminals in the striatum was estimated. The number of dopaminergic SNpc neurons were reduced in D1(/) and D2(/) mice. Density of dopaminergic terminals was unchanged in D1(/) mice and increased in D2 (/) mice. Steady-state striatal DA and DOPAC levels revealed that dopamine activity was enhanced in D2(/) mice but reduced in D1(/) mice.

Two months after partial SNpc lesions, striatal terminal density was normal in both wild-type and D1(/) mice but reduced in D2(/) mice. Administration of DA receptor antagonists resulted in larger terminal arbors in D1(/) and wild-type mice, whereas D2(/) mice showed no change in terminal density.

Functional blockade of the D2R during development or in the adult brain results in increased axonal sprouting. Partial SNpc lesions resulted in compensatory sprouting, only in mice with functional D2R. These results suggest that individual dopaminergic axons in D2(/) mice have reached maximal arbor size. We conclude that the D2 receptor may play a role in modulating the extent of the terminal arbor of SNpc neurons.

Key words: regeneration; dopamine receptors; sprouting; axonal arbor; dopamine antagonists; D1 receptor knock-out; D2 receptor knock-out; 6-OHDA lesions

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21145147-11$05.00/0

This article has been cited by other articles:

				W.-M. Qu, Z.-L. Huang, X.-H. Xu, N. Matsumoto, and Y. Urade Dopaminergic D1 and D2 Receptors Are Essential for the Arousal Effect of Modafinil J. Neurosci., August 20, 2008; 28(34): 8462 - 8469. [Abstract] [Full Text] [PDF]

				J. Lee, W.-M. Zhu, D. Stanic, D. I. Finkelstein, M. H. Horne, J. Henderson, A. J. Lawrence, L. O'Connor, D. Tomas, J. Drago, et al. Sprouting of dopamine terminals and altered dopamine release and uptake in Parkinsonian dyskinaesia Brain, June 1, 2008; 131(6): 1574 - 1587. [Abstract] [Full Text] [PDF]

				J. Mijatovic, M. Airavaara, A. Planken, P. Auvinen, A. Raasmaja, T. P. Piepponen, F. Costantini, L. Ahtee, and M. Saarma Constitutive Ret Activity in Knock-In Multiple Endocrine Neoplasia Type B Mice Induces Profound Elevation of Brain Dopamine Concentration via Enhanced Synthesis and Increases the Number of TH-Positive Cells in the Substantia Nigra J. Neurosci., May 2, 2007; 27(18): 4799 - 4809. [Abstract] [Full Text] [PDF]

				M. Welter, D. Vallone, T. A. Samad, H. Meziane, A. Usiello, and E. Borrelli Absence of dopamine D2 receptors unmasks an inhibitory control over the brain circuitries activated by cocaine PNAS, April 17, 2007; 104(16): 6840 - 6845. [Abstract] [Full Text] [PDF]

				C. L. Parish, J. Nunan, D. I. Finkelstein, F. N. McNamara, J. Y. Wong, J. L. Waddington, R. M. Brown, A. J. Lawrence, M. K. Horne, and J. Drago Mice Lacking the {alpha}4 Nicotinic Receptor Subunit Fail to Modulate Dopaminergic Neuronal Arbors and Possess Impaired Dopamine Transporter Function Mol. Pharmacol., November 1, 2005; 68(5): 1376 - 1386. [Abstract] [Full Text] [PDF]

				D. T. Stephenson, M. D. Meglasson, M. A. Connell, M. A. Childs, E. Hajos-Korcsok, and M. E. Emborg The Effects of a Selective Dopamine D2 Receptor Agonist on Behavioral and Pathological Outcome in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Treated Squirrel Monkeys J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1257 - 1266. [Abstract] [Full Text] [PDF]

				Z. C. Baquet, P. C. Bickford, and K. R. Jones Brain-Derived Neurotrophic Factor Is Required for the Establishment of the Proper Number of Dopaminergic Neurons in the Substantia Nigra Pars Compacta J. Neurosci., June 29, 2005; 25(26): 6251 - 6259. [Abstract] [Full Text] [PDF]

				B. Picconi, D. Centonze, S. Rossi, G. Bernardi, and P. Calabresi Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism Brain, July 1, 2004; 127(7): 1661 - 1669. [Abstract] [Full Text] [PDF]

				N. Kholodilov, O. Yarygina, T. F. Oo, H. Zhang, D. Sulzer, W. Dauer, and R. E. Burke Regulation of the Development of Mesencephalic Dopaminergic Systems by the Selective Expression of Glial Cell Line-Derived Neurotrophic Factor in Their Targets J. Neurosci., March 24, 2004; 24(12): 3136 - 3146. [Abstract] [Full Text] [PDF]

				T. F. Oo, N. Kholodilov, and R. E. Burke Regulation of Natural Cell Death in Dopaminergic Neurons of the Substantia Nigra by Striatal Glial Cell Line-Derived Neurotrophic Factor In Vivo J. Neurosci., June 15, 2003; 23(12): 5141 - 5148. [Abstract] [Full Text] [PDF]

				A. Ben-Shlomo, I. Miklovsky, S.-G. Ren, W. H. Yong, A. P. Heaney, M. D. Culler, and S. Melmed Leukemia Inhibitory Factor Regulates Prolactin Secretion in Prolactinoma and Lactotroph Cells J. Clin. Endocrinol. Metab., February 1, 2003; 88(2): 858 - 863. [Abstract] [Full Text] [PDF]

				Y. Schmitz, C. Schmauss, and D. Sulzer Altered Dopamine Release and Uptake Kinetics in Mice Lacking D2 Receptors J. Neurosci., September 15, 2002; 22(18): 8002 - 8009. [Abstract] [Full Text] [PDF]

				C. L. Parish, D. I. Finkelstein, W. Tripanichkul, A. R. Satoskar, J. Drago, and M. K. Horne The Role of Interleukin-1, Interleukin-6, and Glia in Inducing Growth of Neuronal Terminal Arbors in Mice J. Neurosci., September 15, 2002; 22(18): 8034 - 8041. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help