QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kruzich, P. J. Articles by See, R. E. Search for Related Content PubMed PubMed Citation Articles by Kruzich, P. J. Articles by See, R. E.

 Previous Article  |  Next Article 

The Journal of Neuroscience, 2001, 21:RC155:1-5

RAPID COMMUNICATION
Differential Contributions of the Basolateral and Central Amygdala in the Acquisition and Expression of Conditioned Relapse to Cocaine-Seeking Behavior

Paul J. Kruzich¹ and Ronald E. See²

¹ The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, and ² Department of Physiology and Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425

The amygdala is known to be a critical mediator of emotional learning in aversive and appetitive conditioning. Here we show for the first time that distinct subregions of the amygdala play unique roles in the acquisition and expression of cocaine-seeking behavior maintained by drug-paired cues in a model of relapse. Reversible inactivation of the basolateral amygdala with the sodium channel blocker tetrodotoxin disrupted both the acquisition and expression of the conditioned reinforcing effects maintained by drug-paired stimuli. However, inactivation of the central amygdala disrupted only the expression, but not the acquisition, of the conditioned reinforcing effects of drug-paired stimuli. Our results demonstrate that these nuclei participate as components of an amygdalar circuit to drive cocaine-seeking behavior produced by stimulus-reinforcement associations.

Key words: basolateral amygdala; central amygdala; cocaine; relapse; self-administration; reinforcement

---

Copyright © Society for Neuroscience  0270-6474//$05.00/0

This article has been cited by other articles:

				E. Knapska, K. Radwanska, T. Werka, and L. Kaczmarek Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse Physiol Rev, October 1, 2007; 87(4): 1113 - 1173. [Abstract] [Full Text] [PDF]

				R. A. Fuchs, K. A. Evans, M. P. Parker, and R. E. See Differential Involvement of Orbitofrontal Cortex Subregions in Conditioned Cue-Induced and Cocaine-Primed Reinstatement of Cocaine Seeking in Rats J. Neurosci., July 21, 2004; 24(29): 6600 - 6610. [Abstract] [Full Text] [PDF]

				W. Sun and G. V. Rebec Lidocaine Inactivation of Ventral Subiculum Attenuates Cocaine-Seeking Behavior in Rats J. Neurosci., November 12, 2003; 23(32): 10258 - 10264. [Abstract] [Full Text] [PDF]

				R. M. Carelli, J. G. Williams, and J. A. Hollander Basolateral Amygdala Neurons Encode Cocaine Self-Administration and Cocaine-Associated Cues J. Neurosci., September 10, 2003; 23(23): 8204 - 8211. [Abstract] [Full Text] [PDF]

				A. Dhaka, R. M. Costa, H. Hu, D. K. Irvin, A. Patel, H. I. Kornblum, A. J. Silva, T. J. O'Dell, and J. Colicelli The RAS Effector RIN1 Modulates the Formation of Aversive Memories J. Neurosci., February 1, 2003; 23(3): 748 - 757. [Abstract] [Full Text] [PDF]

				U. Shalev, J. W. Grimm, and Y. Shaham Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review Pharmacol. Rev., March 1, 2002; 54(1): 1 - 42. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help