 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 2001, 21(15):5607-5619
Development of Layer I Neurons in the Primate Cerebral Cortex
Nada Zecevic1 and Pasko Rakic2 1 Department of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut 06030-3401, and 2 Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510-8001
Layer I, which plays an important role in the development of the cerebral cortex, expands in size and diversity in primates. We found that, unlike in rodents, in the macaque monkey, neurons of this layer are generated during the entire 2 month period of corticogenesis, within the middle of the 165-d-long gestation. The large, classical Cajal-Retzius cells, immunoreactive to reelin and calretinin but not to GABA, are generated first [embryonic day 38 (E38)-E50], with the peak of [3H]thymidine ([3H]TdR) labeling at E43. Ultrastructural analysis revealed that processes of these cells form a stereotyped, rectangular network oriented parallel to the pial surface. Genesis of smaller, GABAergic neurons begins slightly later (E43), reaches a peak of [3H]TdR labeling between E54 and E70, and continues until the completion of corticogenesis (E94). These late-generated layer I cells are imported from outside sources such as the olfactory primordium and ganglionic eminence and via a massive subpial granular layer that may also supply some GABAergic interneurons to the subjacent cortical plate. The ratio of large-to-small layer I neurons changes differentially, indicating that each class is produced and/or eliminated at a different rate and suggesting that their roles in primates are diverse.
Key words: neurogenesis; neuronal migration; neocortex; Cajal-Retzius cells; reelin; macaque monkey
Copyright © 2001 Society for Neuroscience 0270-6474/01/21155607-13$05.00/0
This article has been cited by other articles:
Z. Petanjek, B. Berger, and M. Esclapez
Origins of Cortical GABAergic Neurons in the Cynomolgus Monkey
Cereb Cortex, February 1, 2009; 19(2): 249 - 262.
[Abstract] [Full Text] [PDF]
T. Inoue, M. Ogawa, K. Mikoshiba, and J. Aruga
Zic Deficiency in the Cortical Marginal Zone and Meninges Results in Cortical Lamination Defects Resembling Those in Type II Lissencephaly
J. Neurosci., April 30, 2008; 28(18): 4712 - 4725.
[Abstract] [Full Text] [PDF]
M. F. Casanova and C. R. Tillquist
Encephalization, Emergent Properties, and Psychiatry: A Minicolumnar Perspective
Neuroscientist, February 1, 2008; 14(1): 101 - 118.
[Abstract] [PDF]
M. Milh, A. Kaminska, C. Huon, A. Lapillonne, Y. Ben-Ari, and R. Khazipov
Rapid Cortical Oscillations and Early Motor Activity in Premature Human Neonate
Cereb Cortex, July 1, 2007; 17(7): 1582 - 1594.
[Abstract] [Full Text] [PDF]
N. Salamon, M. Andres, D. J. Chute, S. T. Nguyen, J. W. Chang, M. N. Huynh, P. S. Chandra, V. M. Andre, C. Cepeda, M. S. Levine, et al.
Contralateral hemimicrencephaly and clinical-pathological correlations in children with hemimegalencephaly
Brain, February 1, 2006; 129(2): 352 - 365.
[Abstract] [Full Text] [PDF]
C. Wonders and S. A. Anderson
Cortical Interneurons and Their Origins
Neuroscientist, June 1, 2005; 11(3): 199 - 205.
[Abstract] [PDF]
M. Andres, V. M. Andre, S. Nguyen, N. Salamon, C. Cepeda, M. S. Levine, J. P. Leite, L. Neder, H. V. Vinters, and G. W. Mathern
Human Cortical Dysplasia and Epilepsy: An Ontogenetic Hypothesis Based on Volumetric MRI and NeuN Neuronal Density and Size Measurements
Cereb Cortex, February 1, 2005; 15(2): 194 - 210.
[Abstract] [Full Text] [PDF]
C. Zimmer, M.-C. Tiveron, R. Bodmer, and H. Cremer
Dynamics of Cux2 Expression Suggests that an Early Pool of SVZ Precursors is Fated to Become Upper Cortical Layer Neurons
Cereb Cortex, December 1, 2004; 14(12): 1408 - 1420.
[Abstract] [Full Text] [PDF]
J. A. Siegenthaler and M. W. Miller
Transforming Growth Factor {beta}1 Modulates Cell Migration in Rat Cortex: Effects of Ethanol
Cereb Cortex, July 1, 2004; 14(7): 791 - 802.
[Abstract] [Full Text] [PDF]
H. Abraham, C. G. Perez-Garcia, and G. Meyer
p73 and Reelin in Cajal-Retzius Cells of the Developing Human Hippocampal Formation
Cereb Cortex, May 1, 2004; 14(5): 484 - 495.
[Abstract] [Full Text] [PDF]
S. Rakic and N. Zecevic
Emerging Complexity of Layer I in Human Cerebral Cortex
Cereb Cortex, October 1, 2003; 13(10): 1072 - 1083.
[Abstract] [Full Text] [PDF]
E. S. B. C. Ang Jr, T. F. Haydar, V. Gluncic, and P. Rakic
Four-Dimensional Migratory Coordinates of GABAergic Interneurons in the Developing Mouse Cortex
J. Neurosci., July 2, 2003; 23(13): 5805 - 5815.
[Abstract] [Full Text] [PDF]
S. Nishikawa, S. Goto, T. Hamasaki, K. Yamada, and Y. Ushio
Involvement of Reelin and Cajal-Retzius Cells in the Developmental Formation of Vertical Columnar Structures in the Cerebral Cortex: Evidence from the Study of Mouse Presubicular Cortex
Cereb Cortex, October 1, 2002; 12(10): 1024 - 1030.
[Abstract] [Full Text] [PDF]
G. Radnikow, D. Feldmeyer, and J. Lubke
Axonal Projection, Input and Output Synapses, and Synaptic Physiology of Cajal-Retzius Cells in the Developing Rat Neocortex
J. Neurosci., August 15, 2002; 22(16): 6908 - 6919.
[Abstract] [Full Text] [PDF]
S. N. Roper and A. T. Yachnis
Book Review: Cortical Dysgenesis and Epilepsy
Neuroscientist, August 1, 2002; 8(4): 356 - 371.
[Abstract] [PDF]
G. Meyer, C. G. Perez-Garcia, H. Abraham, and D. Caput
Expression of p73 and Reelin in the Developing Human Cortex
J. Neurosci., June 15, 2002; 22(12): 4973 - 4986.
[Abstract] [Full Text] [PDF]
S.-M. Lu, N. Zecevic, and H. H. Yeh
Distinct NMDA and AMPA Receptor-Mediated Responses in Mouse and Human Cajal-Retzius Cells
J Neurophysiol, November 1, 2001; 86(5): 2642 - 2646.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|